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European Radiology: Application of QSM and VBM in the early diagnosis of Alzheimer's disease
Time of Update: 2022-05-26
GM and QSM images are calculated from the amplitude image of the first echo and the phase images of all echoes, respectively This study proposes a new diagnostic index based on mixed sequence analysis of QSM and VBM for early diagnosis of Alzheimer's disease .
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Neurology: Neurodegenerative markers may be involved in stroke etiology - higher plasma total tau is associated with NFL and increased stroke risk!
Time of Update: 2022-05-26
A population-based prospective study published in Neurology determined whether plasma Aβ, total tau, and NFL levels were associated with stroke and its major subtypes .
A population-based prospective study published in Neurology determined whether plasma Aβ, total tau, and NFL levels were associated with stroke and its major subtypes .
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A&R: Pain time summation and dynamic functional brain connectivity in fibromyalgia
Time of Update: 2022-05-26
In 84 FM patients and age- and sex - matched healthy controls, the researchers collected high-temporal-resolution fMRI data at rest and during pain with continuous cuff pressure applied to the leg .
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Neurology: Lower extremity peripheral nerve damage and dementia risk in black and white older adults
Time of Update: 2022-05-26
Researchers have investigated the association between lower extremity peripheral nerve damage and the risk of developing dementia in black and white older adults .
Researchers have investigated the association between lower extremity peripheral nerve damage and the risk of developing dementia in black and white older adults .
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Neurology: Autopsy validation of the diagnostic accuracy of (123) I-m-iodophenylguanidine myocardial imaging for Lewy body disease
Time of Update: 2022-05-26
The diagnostic accuracy of (123) I-MIBG myocardial scintigraphy in differentiating LBD from similar disorders has been determined based on large autopsy cases .
The diagnostic accuracy of (123) I-MIBG myocardial scintigraphy in differentiating LBD from similar disorders has been determined based on large autopsy cases .
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Neurology: Subcutaneous Long-Term Heart Monitor Helps Detect Severe Arrhythmias in Patients With Refractory Epilepsy!
Time of Update: 2022-05-26
This prospective cohort study aimed to detect arrhythmias in patients with chronic drug-resistant epilepsy (≥5 years duration) using a subcutaneous cardiac monitor with a minimum follow-up of 12 months .
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BMJ: Longevity and dementia prevention, the more of these things you need, the better!
Time of Update: 2022-05-26
A healthy life>promotes brain health (Mediterranean-DASH diet-MIND diet score in the upper 40% of cohort distribution), improved cognitive activity in later life (composite score in the upper 40%) %), moderate or vigorous physical activity (≥150 min/week), non-smoking, and light to moderate alcohol consumption (≤15 g/day for women; ≤30 g/day for men) .
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Alzheimers Res Ther: Professor Han Ying's team found that gut microbiota combined with plasma Aβ can be used as a potential marker to identify preclinical AD
Time of Update: 2022-05-26
amyloid-β as a potential index for identifying preclinical Alzheimer's disease: a cross-sectional analysis from the SILCODE study", which preliminarily explored Aβ-positive subjects with normal cognitive function, namely Alzheimer's disease (Alzheimer's disease, AD) to characterize changes in gut microbiota in preclinical populations and evaluate their potential in combination with plasma Aβ to identify preclinical AD .
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Neurology: New achievements of the neurosurgery team of Peking University Tiantan Hospital - Exon full sequence analysis of De Novo and rare gene variants in patients with cerebral arteriovenous malformations
Time of Update: 2022-05-26
Other interesting genetic studies with smaller sample sizes have also identified several candidate genes for bAVM through triplet/family analysis or sequencing of individual cases .
Other interesting genetic studies with smaller sample sizes have also identified several candidate genes for bAVM through triplet/family analysis or sequencing of individual cases .
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Nature sub-published Fudan study: How long does it take to sleep each night is good for the brain?
Time of Update: 2022-05-26
1038/s43587-022-00210-2 The brain structure and genetic mechanisms underlying the nonlinear association between sleep duration, cognition and mental health.
1038/s43587-022-00210-2 The brain structure and genetic mechanisms underlying the nonlinear association between sleep duration, cognition and mental health.
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Neurology: Changes in peripheral neurofilament light (NFL) levels may be an effective biomarker for spinocerebellar ataxia type 1 (SCA1) pre-ataxia and ataxia stages!
Time of Update: 2022-05-26
Recently, a study published in Neurology hypothesized that NFL levels in SCA1 could serve as (1) a peripheral biomarker close to the onset of clinical ataxia, (2) early neuronal decline in the pre-ataxia phase, and (3) Objective trial outcome variables, allowing reduction of the sample size required in treatment trials .
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The Lancet: Of 57 major diseases, 16 are associated with smaller total brain volume!
Time of Update: 2022-05-26
Adjusted β (95% CI) for total brain, gray matter, hippocampus, and WMH volumes associated with multimorbidity (≥ 6 diseases) were −6·5 (−9·3, −3·6) ml, −9, respectively 4 (−11 1, −7 6) ml, −31.
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Neurology: Patients with impaired renal function are at increased risk of stroke, especially with this subtype!
Time of Update: 2022-05-26
0000000000200153 Etiology and Outcome of Ischemic Stroke in Patients With Renal Impairment Including Chronic Kidney Disease Japan Stroke Data Bank.
0000000000200153 Etiology and Outcome of Ischemic Stroke in Patients With Renal Impairment Including Chronic Kidney Disease Japan Stroke Data Bank.
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Alzheimer&Dementia: Adherence to a healthy lifestyle can reverse the impact of genetic risk factors on Alzheimer's disease
Time of Update: 2022-05-25
Using data from the Chicago Health and Aging Project (1993-2012; n = 3874), the researchers defined genetic risk based on the presence or absence of the lipoprotein E (APOE) 𝜀4 allele and used scores on five factors to determine health life> .
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Nature: Atherosclerotic plaques extend their claws to the central nervous system, and cutting off this claws is expected to fight atherosclerosis
Time of Update: 2022-05-25
"Co-author Professor Daniela Carnevale, from the Department of Vascular Neurology and Translational Medicine at the IRCCS Institute, said: "When there is atherosclerotic plaque, aggregates of immune cells also accumulate in the outer connective tissue of blood vessels -- called arteries.
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Neurology: Peking University Public Health Risk Prediction Model: Using the Chinese Kadoorie Biobank to Build and Predict the Risk of Ischemic and Hemorrhagic Stroke and Ischemic Heart Disease within 10 Years
Time of Update: 2022-05-25
Based on the China Kadoorie Biobank (CKB), one of the largest population-based cohorts in the world, researchers have recently established practical disease-specific and overall cardiac outcomes based on widely available variables in Chinese RHR, including IHD, IS, and HS.
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Eur Heart J: Effects of aspirin on dementia and cognitive function in diabetic patients
Time of Update: 2022-05-25
In primary cardiovascular disease prevention , a recent meta-analysis of randomized trials showed that daily low-dose aspirin was associated with a proportional 11% reduction in the risk of major vascular events (including a 19% reduction in ischemic stroke ), but the risk of major bleeding was reduced by 19%.
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Cerebral Cortex: TV viewing affects the frontal polar regions of the brain linked to intelligence
Time of Update: 2022-05-25
1093/cercor/bht315Hikaru Takeuchi, Yasuyuki Taki, Hiroshi Hashizume, Kohei Asano, Michiko Asano, Yuko Sassa, Susumu Yokota, Yuka Kotozaki, Rui Nouchi, Ryuta Kawashima, The Impact of Television Viewing on Brain Structures: Cross-Sectional and Longitudinal Analyses, Cerebral Cortex , Volume 25, Issue 5, May 2015, Pages 1188–1197, https://doi.
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Neurology: Trends in Outpatient Treatment of Depression in U.S. Stroke Survivors, 2004-2017
Time of Update: 2022-05-25
Using nationally representative data on stroke survivors in the United States from 2004 to 2017, researchers examined (1) overall temporal trends in receiving outpatient care for depression, including race/ethnicity, and comparisons with the non-stroke population.
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Neurology: Higher baseline total tau and neurofilament light chains in plasma are associated with higher stroke risk
Time of Update: 2022-05-25
stroke vesselTo clarify whether Alzheimer's disease-related pathology or neurodegeneration plays a role in stroke etiology, the effects of plasma β- amyloid (Aβ) , total tau , and neurofilament light chain (NfL) levels on stroke and stroke were determined .
