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Neurology: Neurodegenerative markers may be involved in stroke etiology - higher plasma total tau is associated with NFL and increased stroke risk!

 Last Update: 2022-05-26
 Source: Internet
 Author: User

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Stroke and dementia are common neurological disorders in older adults and often co-occur in the same patient

Amyloid plaques are mainly composed of β-amyloid (Aβ) polypeptides and neurofibrillary tangles of tau protein, which are the pathological features of Alzheimer's disease (AD)

A population-based prospective study published in Neurology determined whether plasma Aβ, total tau, and NFL levels were associated with stroke and its major subtypes

Between 2002 and 2005, researchers examined plasma A-beta40, A-beta42, TOTAL-TAU, and NFL in 4661 stroke-free patients from a population-based study in Rotterdam

After a mean follow-up of 10.

Participants with higher total tau and NFL at baseline had a higher risk of stroke and several stroke subtypes

This study provides class II evidence that higher plasma total tau and NFL levels are associated with an increased risk of subsequent stroke

Source: Heshmatollah A, Fani L, Koudstaal PJ, Ghanbari M, Ikram MA, Ikram MK.
Plasma β-Amyloid, Total-Tau, and Neurofilament Light Chain Levels and the Risk of Stroke: A Prospective Population-Based Study.
Neurology.
2022;98(17):e1729-e1737.
doi:10.
1212/WNL.
0000000000200004 Heshmatollah A, Fani L, Koudstaal PJ, Ghanbari M, Ikram MA, Ikram MK.
Plasma β-Amyloid, Total-Tau, and Neurofilament Light Chain Levels and the Risk of Stroke: A Prospective Population-Based Study.
Neurology.
2022;98(17):e1729-e1737.
doi:10.
1212/WNL.
0000000000200004

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