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Zhong Qing/Wang Weiwei, School of Basic Medical Sciences, et al. reported a new spray-type contrast agent that rapidly identifies tumor boundaries
Time of Update: 2023-02-03
During surgery, S-4-NP can be directly sprayed with the isolated tumor tissue section, and the tumor tissue can be clearly identified within 3 minutes through near-infrared imaging, thereby helping clinical surgeons quickly distinguish the boundary between tumor tissue and normal tissue, and judge the surgical margin (see Figure 3 for the complete imaging video).
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Gao Ge's team proposed a new method for cross-modal representation learning
Time of Update: 2023-02-03
Biological processes in cells involve DNA, RNA, proteins and other different levels of regulation, which influence each other and work together, so integrating multimodal information corresponding to
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Science: Chinese scientists led the way in revealing that the ketogenic diet is expected to become a potentially life-saving therapy for cancer patients to combat low platelets
Time of Update: 2023-02-03
In a new preliminary study, researchers from research institutions such as Fudan University in China and Longyan First Hospital affiliated to Fujian Medical University suggest that a high-fat diet ma
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Probiotics/synbiotics play an important role in the regulation of "mother-child integration" of intestinal health and meat quality in Parma swine
Time of Update: 2023-02-03
Related paper information: 1 2 3 4 5 6 7 8 Flow chart of probiotic synbiotics for "mother-child integration" nutritional intervention in Parma Xiang pigs Effect and mechanism of probiotic synbiotic on "mother-child integration" nutritional intervention in Bama Xiang pig After the feed ban, microecological preparations have become an important feed additive to ensure the healthy production of animals.
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JACS Cover Shanghai Institute of Materia Medica's cooperation in the development of a near-infrared secondary small molecule fluorescent probe that can cross the blood-brain barrier
Time of Update: 2023-02-03
On December 13, 2022, Han Xiao's laboratory at Rice University and the team of Cheng Zhen of the Center for Molecular Imaging of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, published a report entitled "Photostable Small-Molecule NIR-II Fluorescent Scaffolds that Cross the Blood" in the Journal of the American Chemical Society Brain Barrier for Noninvasive Brain Imaging", which was selected as the cover article.
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New progress has been made in analyzing the spatial and temporal differences of estuarine fish communities based on environmental DNA technology
Time of Update: 2023-02-03
Recently, the investigation and assessment team of the South China Sea Fishery Resources Investigation and Assessment Team of the South China Sea Fisheries Research Institute of the Chinese Academy o
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Wang Zhao's team at Tsinghua University revealed that a high-fat diet rescued the premature aging-related phenotype of SIRT6 knockout mice by improving the intestinal flora
Time of Update: 2023-02-03
Recently, Professor Wang Zhao's research group of Tsinghua University School of Pharmacy published a research paper in the journal Aging Cell entitled: Decreased Enterobacteriaceae translocation due
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Nature Genetics international large-scale research has revealed dozens of new genes linked to heart disease
Time of Update: 2023-02-03
Most of the new genomic loci were associated with very small changes in CAD risk, suggesting that few, if any, common genetic variants that had a significant impact on CAD risk by studying people of predominantly European ancestry were yet to be discovered, and to improve their discovery power, the researchers combined their large dataset with data from tens of thousands of individuals of East Asian descent from the Japan Biobank, including 29,000 CAD patients.
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Proc. Natl. Acad. Sci. U.S.A.: Development of new probe for mitochondrial multicolor STED imaging
Time of Update: 2023-02-03
published a research paper entitled "Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain" and was selected as the cover article 。 The study reported a mitochondrial crest dye PK Mito Orange (PKMO) suitable for STED nanomicroscopy with excellent photostability and significantly reduced phototoxicity, enabling long-term, super-resolution mitochondrial dynamic imaging in immortalized mammalian cell lines, primary cells, and tissues, 3D-STED imaging of individual mitochondria, and multicolor STED imaging (Figure 1).
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Eye tracking in visual challenges reveals neural coding
Time of Update: 2023-02-03
Instead, human vision is an active process that includes interactions between external objects and eye movements," Ahissar said.
Instead, human vision is an active process that includes interactions between external objects and eye movements," Ahissar said.
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New bacterial therapies for lung cancer
Time of Update: 2023-02-03
Researchers at Columbia University's School of Engineering report that they have developed a preclinical evaluation pipeline for the characterization of bacterial therapies in lung cancer models.
Researchers at Columbia University's School of Engineering report that they have developed a preclinical evaluation pipeline for the characterization of bacterial therapies in lung cancer models.
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New progress has been made in the study of the basic regulation and evolutionary pathways of the specific reproductive patterns of the main pathogen taxa of fungal meningitis
Time of Update: 2023-02-03
The research team of Wang Linqi, State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, published an article entitled "Regulatory basis for reproductive flexibility in a meningitis-causing fungal pathogen" in Nature Communications.
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Professor Yimin Cui's team from the Department of Pharmaceutical Affairs Management and Clinical Pharmacy published a blockbuster review in the journal STTT, a sub-journal of Nature: Targeting Integrin Pathways: From Signaling Pathways to Therapeutic Strategies
Time of Update: 2023-02-03
On January 2, 2023, the team of Professor Cui Yimin from the Department of Pharmaceutical Affairs Management and Clinical Pharmacy of Peking University School of Pharmacy presented in the Signal Transduction and Targeted sub-journal Nature The journal Therapy (STTT, Q1, IF=38.
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Current Biology: Why children learn more efficiently than adults
Time of Update: 2023-02-03
Takeo Watanabe of Brown University said: "Our findings suggest that primary school-age children can learn more than adults in a given amount of time, which makes them learn more efficiently.
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Nature Communications: Efficient and safe gene editing with Cas9TX in a mouse model of age-related macular degeneration
Time of Update: 2023-02-03
In the in vivo gene editing therapy model of age-related macular degeneration (AMD), this work quantitatively reveals for the first time the occurrence mode and frequency of chromosomal translocation and adeno-associated virus fragment insertion of CRISPR-Cas9 in the process of gene editing in vivo, and greatly reduces the production of these byproducts in the in vivo gene editing process by using the Cas9TX variant previously developed by the research group.
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Use the sword of biological network big data to solve the mystery of corn genetics
Time of Update: 2023-02-03
Inheritance and innovation kicked off the era of maize multi-dimensional network map On December 30, 2022, the journal Nature and Genetics published the collaborative research paper "A multi-omics in
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Brain metastases in melanoma patients, deciphering important molecular mechanisms
Time of Update: 2023-02-03
Different cell states determine the progression of the diseaseThe study's last author, Torben Redmer from the Institute of Medical Biochemistry and Pathology in Vetmeduni, summed up the main findings: "Our study provides evidence that MBMs can be divided into at least two subgroups.
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Nature: After contracting the new coronavirus, has the body's response to other threats changed? It depends on the gender
Time of Update: 2023-02-03
In the study, a team led by Tsang, who at the time at the National Institute of Allergy and Infectious Diseases (NIAID), and his colleagues, including lead author Rachel Sparks, also from NIAID, systematically analyzed the immune response in healthy people who received the flu vaccine.
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Nature Cancer: Triple immunotherapy holds promise for treating pancreatic cancer
Time of Update: 2023-02-03
1038/s43018-022-00500-z Researchers at the University of Texas MD Anderson Cancer Center have discovered a novel pancreatic cancer immunotherapy combination that targets T cell checkpoints and myeloid suppressor cells, successfully reprogrammed the tumor immune microenvironment (TIME), and significantly improved anti-tumor responses in pancreatic cancer models.
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Japanese scientists expand stockpile of drugs to fight COVID-19
Time of Update: 2023-02-03
While testing a group of compounds known to have inhibitory activity against the 2002 SARS-CoV virus, the research team identified a compound called 5h, which showed activity to inhibit SARS-CoV-2 Mpro, but was inefficient and unstable.