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ACS Nano Shanghai Institute of Materia Medica, co-developed nanoprobes for imaging and treatment of brain glioma
Time of Update: 2023-02-03
Recently, Professor Liu Hong of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Professor Ye Deju of Nanjing University have cooperated to make the latest research progress in the research of targeted activated organic co-assembled nanodiagnostic and therapeutic probes for near-infrared fluorescence-magnetic resonance dual-modal imaging and chemotherapy-photodynamic combination therapy for brain gliomas in situ.
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NEJM: The world's first successful treatment of a rare genetic disease in an unborn baby in utero
Time of Update: 2023-02-03
Doctors and researchers at the University of California, San Francisco, Duke University and the University of Ottawa have successfully used enzyme replacement therapy (ERT) for the first time to treat a fetus with Pompe disease still in the womb, and the little girl is now one and a half years old, has reached developmental milestones, has a normal heart and muscle function, can walk, and has normal biomarkers of muscle damage and glycogen accumulation.
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Alzheimer's disease: a gene associated with immune cells in the brain
Time of Update: 2023-02-03
Researchers at Indiana University School of Medicine are studying how to reduce a genetic variant found in brain immune cells that reduces the risk of late-onset Alzheimer's disease.
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Nature: After contracting the new coronavirus, has the body's response to other threats changed? It depends on the gender
Time of Update: 2023-02-03
In the study, a team led by Tsang, who at the time at the National Institute of Allergy and Infectious Diseases (NIAID), and his colleagues, including lead author Rachel Sparks, also from NIAID, systematically analyzed the immune response in healthy people who received the flu vaccine.
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Japanese scientists expand stockpile of drugs to fight COVID-19
Time of Update: 2023-02-03
While testing a group of compounds known to have inhibitory activity against the 2002 SARS-CoV virus, the research team identified a compound called 5h, which showed activity to inhibit SARS-CoV-2 Mpro, but was inefficient and unstable.
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Chen Saijuan's team's latest research: the proportion of severe cases in hospitalized patients with the new crown is about 3%, and the Spring Festival will accelerate the wave of infection, and vulnerable groups need to be protected
Time of Update: 2023-02-03
To assess the proportion of severe/critical cases among symptomatic hospitalized patients, the research team carefully examined 5,706 symptomatic patients admitted to Shanghai Public Health Clinical Center between September 1 and December 26, 2022, and divided them into 4 groups based on symptom severity and past medical history.
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The regulation of bile acid metabolism in piglets with intrauterine growth retardation has progressed in stages
Time of Update: 2023-02-03
Paper links: 1 2 3 4 5 6 7 Feeding effect of bile acids added to feed on normal pigs and IUGR piglets Intrauterine growth retardation (IUGR) is a general term for fetal growth and development disorders in the mother's womb, IUGR animals are manifested as growth retardation, abnormal development, disease resistance and decreased meat quality, early morbidity and mortality are high.
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Hoarding medicine is not as good as hoarding "good body": New Year's exercise goals can be set a little lower, just a few minutes a day
Time of Update: 2023-02-03
New research shows that even muscle contractions once a day, 5 days a week, can improve muscle strength if you stick to it for a month.
New research shows that even muscle contractions once a day, 5 days a week, can improve muscle strength if you stick to it for a month.
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Immunity: The complexity of TRM cell biology in the gut
Time of Update: 2023-02-03
The researchers observed that TRM cells of each tissue type exhibited different cytokine and granzyme expression patterns, as well as substantial transcriptional, epigenetic, and functional heterogeneity.
The researchers observed that TRM cells of each tissue type exhibited different cytokine and granzyme expression patterns, as well as substantial transcriptional, epigenetic, and functional heterogeneity.
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Nature Subissue: The secret language of decoding photosynthesis
Time of Update: 2023-02-03
Previously, Chen's team demonstrated that certain proteins in the nucleus of plants are activated by light, initiating photosynthesis.
Previously, Chen's team demonstrated that certain proteins in the nucleus of plants are activated by light, initiating photosynthesis.
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"Nature": Fudan Yuan Peng and others discovered a new mechanism of cognitive decline in Alzheimer's disease patients!
Time of Update: 2023-02-03
The researchers analyzed human brain autopsy samples and found that in the brains of patients with moderate to severe AD, the average number of PAAS near each amyloid plaque was higher and larger, suggesting that the number and size of PAAS may be important factors affecting neural circuit connections and cognitive function in AD patients.
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New bacterial therapies for lung cancer are released
Time of Update: 2023-02-03
To test the hypothesis, the researchers blocked these pathways with current anti-cancer drugs and showed that combining the drugs with bacterial toxins was more effective at eliminating lung cancer cells.
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The Lancet Psychiatry: During the pandemic, 1 in 5 healthcare workers in the UK had mental health problems
Time of Update: 2023-02-03
Previous studies have shown that the prevalence of anxiety and depression among healthcare workers during the pandemic ranged from 9 to 90 percent and 5 to 65 percent, respectively, and the prevalence of post-traumatic stress disorder (PTSD) ranged from 7 to 37 percent [1].
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AD: Middle-aged fat, thin in old age, dementia risk soared 288%!
Time of Update: 2023-02-03
From the results of the Cox regression model (Figure 2), it is not difficult to find that there is no significant statistical association between people with early BMI decline and late BMI decline and the occurrence of dementia.
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The NEJM China clinical trial shows that the new coronavirus drug may be superior to Paxlovid
Time of Update: 2023-02-03
In a phase III clinical trial conducted in China, the treatment, called VV116, like Paxlovid, was effective in people at high risk of severe disease.
In a phase III clinical trial conducted in China, the treatment, called VV116, like Paxlovid, was effective in people at high risk of severe disease.
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Zheng Lemin's team discovered a new mechanism by which putrescine in smooth muscle cells promotes the development of abdominal aortic aneurysm
Time of Update: 2023-02-03
202 2 February 25 Zheng Lemin Group, Institute of Cardiovascular Research, School of Basic Medical Sciences The team published an online publication entitled "GasderminD deficiency in vascular smooth muscle cellsameliorates" in the internationally renowned journal Advanced Science Abdominal aortic aneurysm through reducing putrescine synthesis" paper reports that GSDMD can be accessed in aortic smooth muscle cells Promoting putrescine synthesis and aggravating the development of abdominal aortic aneurysm.
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Chengdu Biotech Institute has made new progress in the research of heteroautotrophic coupled nitrogen removal in the high ammonia nitrogen load leachate system
Time of Update: 2023-02-03
8;font-family:;font-size:12pt;} The short-range nitrification-denitrification process refers to the inhibition or elimination of nitrite oxidizing bacteria in the system, so that the conversion of nitrogen is limited to the oxidation ofNH4+ to NO2-, In addition, NO2- is reduced to N2, eliminating the nitrate conversion step and saving the amount of aeration and carbon source addition in the system.
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New progress has been made in the research on the anti-rust mechanism of coffee
Time of Update: 2023-02-03
Large-grain coffee transcript annotation (A) and single-copy gene-constructed coffee genus maximum likelihood tree (B) Coffee rust caused by Hemileia vastatrix is a devastating disease that has become an important crop protection problem restricting coffee production.
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A milestone in cell biology! A database of 200,000 cell images to understand our cellular building blocks
Time of Update: 2023-02-03
The composite average of cells that transformed the image on the screen showed 17 selected structuresA division of the Allen Institute, the Allen Institute for Cell Science, produced a digital description of the internal organization of human cells by processing hundreds of thousands of high-resolution images — a biological concept that has so far been very difficult to quantify.
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PNAS: "Jumping genes" help fungi kill salamanders
Time of Update: 2023-02-03
Two-speed genome evolution drives pathogenicity in fungal pathogens of animals Image: SalamanderPhoto by Jaime BoschScientists have found that a fungus infected with salamanders contains multiple copies of the same "jumping gene.