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Antibody sequencing provides a new avenue for antibody therapy research
Time of Update: 2023-01-01
Using Fast-Sequence's protein discovery platform, researchers can quickly identify and develop different natural antibodies in the body, thereby accelerating the drug development process.
Using Fast-Sequence's protein discovery platform, researchers can quickly identify and develop different natural antibodies in the body, thereby accelerating the drug development process.
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Nature: Significant progress! In Alzheimer's disease, the protein medin interacts with β amyloid and is co-deposited in blood vessels in the brain
Time of Update: 2023-01-01
Experts are uncontroversial that in addition to the aggregation of Aβ in brain tissue, vascular alterations--- that is, decreased or damaged blood vessel function--- also contribute to the development of Alzheimer's disease.
com)Resources:Jessica Wagner et al.
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The genetic stability of rice without fusion reproductive hybrids was systematically studied
Time of Update: 2023-01-01
Recently, the genome editing and fusion-free reproductive innovation team of China Rice Research Institute propagated non-fusion reproductive hybrid rice materials to the 4th generation, and compared different generations of cloned materials from the levels of plant phenotype, genome, methylation, transcriptome and subgenomic transcription, which confirmed the genetic stability of non-fusion reproductive hybrid rice between different generations, and laid a theoretical foundation for the future application of artificial non-fusion reproductive system in crops.
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The latest international research: high-fat diet during pregnancy may have a stronger effect on the nervous system of male offspring
Time of Update: 2023-01-01
Beijing, Nov. 30 (Reporter Sun Zifa) Springer Nature's professional academic journal "Nature-Metabolism" published a new paper saying that researchers based on research on mouse and human tissues found that a high-fat diet during pregnancy may increase the susceptibility of offspring, especially male offspring, to neurological diseases by disrupting communication between the placenta and the fetal brain.
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Nature: Intestinal flora is closely related to the onset of Parkinson's disease
Time of Update: 2023-01-01
Of the 84 intestinal microorganisms associated with Parkinson's disease, 55 were abundant in the gut of Parkinson's patients, and 29 were abundantly low.
Of the 84 intestinal microorganisms associated with Parkinson's disease, 55 were abundant in the gut of Parkinson's patients, and 29 were abundantly low.
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First Science and then Cell, the mechanism of eating less to prolong life has been found, reducing proteins related to the aging process
Time of Update: 2023-01-01
The study discovered the mechanism of eating less to prolong life, and moderate calorie restriction reduces the production of the aging process-related protein SPARC, which inhibits harmful inflammation, improves metabolism, and extends healthy lifespan with age.
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Nature: New research clearly reveals that adenosine is a neurotransmitter that acts as opposed to dopamine
Time of Update: 2023-01-01
In a new study, researchers from Oregon Health and Science University in the United States found that the neurotransmitter adenosine has an effective braking effect on dopamine, another widely known neurotransmitter involved in motor control.
com)Resources:Lei Ma et al.
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Blockbuster highlight study that Nature magazine had to watch in November!
Time of Update: 2023-01-01
Time flies, November is coming to an end, and in the coming November, what are the highlights of Nature Magazine's research worth learning? The editor has sorted out the relevant articles and studied
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JCO: Dosage reduced by 90%, efficacy doubled! PD-1 inhibitors work better with this regimen
Time of Update: 2023-01-01
5 of the normal dose based on the body weight of a 60 kg patient, and such a low dose of nivolumab combined with beat chemotherapy could improve the one-year survival rate of HNSCC patients receiving palliative care from 16.
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Adults living in areas with high levels of air pollution are more likely to suffer from multiple long-term health problems
Time of Update: 2023-01-01
A new UK study of 364,000 people shows that exposure to traffic-related air pollution increases the likelihood of multiple long-term physical and mental health problems.
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1 article in Nature + 1 Cell sub-journal reveals that tumor bacteria help tumor progression and resistance to treatment
Time of Update: 2023-01-01
Dr. Susan Bullman, a cancer microbiome researcher at Fred Hutchinson Cancer Center and co-corresponding author of the two studies, said of the first study, "What we showed is that in some areas of the tumor, --- micro-niche regions, there is a large number of bacterial colonizations that are functionally different from areas without bacteria.
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Nature: revealed that the APOE4 gene causes lipid dysregulation in oligodendrocytes, destroying neuronal myelination, thereby increasing the risk of Alzheimer's disease
Time of Update: 2023-01-01
It is known that carrying one copy of the APOE4 gene variant triples a person's risk of developing Alzheimer's disease, and carrying two copies of it increases that risk about tenfold, but the underl
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The role of snoRNP in thermospermine-mediated Arabidopsis thaliana growth and development was found to be found in the study
Time of Update: 2023-01-01
A working model of T-SPM regulating Arabidopsis thaliana growth and development Polyamines are widely found in bacteria, yeast, animals and plants.
A working model of T-SPM regulating Arabidopsis thaliana growth and development Polyamines are widely found in bacteria, yeast, animals and plants.
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Nature Cancer: Chinese scientists discover signs that "cancer king" is sensitive to "synthetic lethality"
Time of Update: 2023-01-01
1093/nar/gkab415 RNA,RNA6(m6A)2011,[1]。RNA m6A[2-3],METTL16[4-5]。,(Mayo Clinic)、,,《·》METTL16[6]。,METTL16RNA,,MRE11,DNA。DNA,METTL16ATM,,RNA,MER11METTL16。,,METTL16PARP,。FDA[7]。,10%,。,METTL16DNA,PARP。,、,。RNA m6ADNA[8-9],m6A(METTL3-METTL14,METTL16)DNA。DNA(DSB)METTL3-METTL14,METTL16,,METTL16DSB。,DSB(DR-GFP/EJ5-GFP),HEK293TMETTL16(HDR)DNA。METTL16DNA,。METTL16DSBMETTL16METTL16,DSB。,8,,METTL16(KO)γ-H2AX(DSB)。,4,KODNA。METTL16,γ-H2AXDNA。,METTL16DNA。METTL16DNA,DSB,METTL16ATM/ATR(DNA)(Ser419Ser455)。,METTL16ATM/ATR。。、,ATMMETTL16Ser419,HDR。ATMMETTL16HRHDRDNA,(end resection)、3’-(strand invasion)、Holliday(resolution of Holliday Junction)。,METTL16HDR?The researchers found that after 2 hours of radiation treatment, compared with normally expressed METTL16, METTL16 knockout cells had significantly increased levels of proteins RPA32 and RAD51, and reexpression of METTL16 could reverse these changes.
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Nature: Why does fat increase after dieting? How protein helps with weight loss
Time of Update: 2023-01-01
A study led by Professor Zhai Qiwei of the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, published in the journal Nature Metabolism, showed that the increase in lactic acid bacteria and their metabolites after dieting enhanced intestinal lipid absorption in mice, leading to rapid fat accumulation and obesity.
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A new study finds that 70 percent of Florida's coral reefs are being eroded
Time of Update: 2023-01-01
"These findings underscore the need for enhanced management strategies, such as planting corals, to help restore coral structures that have been lost," said study co-author Erica Towle, coordinator of NOAA's National Coral Reef Monitoring Program and an alumnus of the UM Rosenstiel Academy.
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Entering the Expo, Double 11 Double End! Sailifu AI multi-target anti-aging technology attracts attention
Time of Update: 2023-01-01
AI multi-target anti-aging technology innovation leadsSince the establishment of the brand, Sailifu has adhered to scientific research as the foundation and established a "health system" integrated with three major centers: scientific research center, product center and health center, and the scientific research center covers four major anti-aging research platforms: holographic aging big data analysis platform, core raw material selection platform, advanced preparation process research and development platform, and systematic testing application platform, with profound scientific research achievements.
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November 2022 Science Journal Highlights
Time of Update: 2023-01-01
November 2022 is coming to an end, what are the highlights of the Science journal worth learning in November? The editor has sorted out this and shared it with you. 1. Science: The universal flu vacc
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The Chinese Agricultural Society organized and held a scientific and technological achievement evaluation meeting of the academician Yin Yulong team
Time of Update: 2023-01-01
Outcome evaluation meeting site On December 5th, experts from the Chinese Agricultural Society organized experts to evaluate the scientific and technological achievements of "Analysis and Intervention of Nutritional Diarrhea Mechanism and Intervention of Piglets Key Technological Innovation and Application" completed by the team of Academician Yin Yulong of the Institute of Subtropical Agroecology, Chinese Academy of Sciences.
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JACC: Falling off the altar, good cholesterol does not reduce the risk of heart disease
Time of Update: 2023-01-01
Researchers from the University of Vermont and Oregon Health and Science University published a research paper titled "Race-Dependent Association of High-Density Lipoprotein Cholesterol Levels With Incident Coronary Artery Disease" in the journal "JACC" of the American College of Cardiology。The study showed that good cholesterol does not prevent cardiovascular disease risk and even increases it.