Aging: Revealing the key role that lamin plays in the body's normal aging process

Almost ever since scientists discovered that mutations in the LMNA genes encoding the nuclear structural components lamin A and C lead to Hutchinson-Gilford Progeria syndrome, they have speculated that lamins may play an important role
in the body's normal aging process 。 The most common HPGS mutation produces a splice variant, progerin, a splice variant of lamin A, which promotes the pathological process
of accelerated aging.

Although there is current research evidence that progerin accumulates with normal aging of the body, more and more research evidence suggests that as a precursor of lamin A before the enzymatic digestion process of C-terminal protein, prelamin A accumulates with the aging of the body and may become a driver of normal aging of the body, and the protein can also share the characteristics of progerin, and also with a skin disease called restrictive skin disease (restrictive).
Dermopathy) is directly related
to Progeria.

Revealing the key role
that lamin plays in the body's normal aging process.

Image source: Aging (2022).
DOI:10.
18632/aging.
204342

Recently, in a research report entitled "Lamin A to Z in normal aging" published in the international journal Aging, scientists from the United States and Singapore revealed the molecular mechanism behind the change of prolayer protein A with the aging of the body, and the researchers also proposed that this unprocessed protein affects the normal aging of the body
.

The researchers said that patients with laminopathy and restrictive skin diseases will carry mutations in ZMPSTE24 or LMNA, LMNA mutations or directly related to the alteration and accumulation of prelayer protein A processing, patients with restrictive skin diseases may show some signs of accelerated aging of the body, however, this condition is often early and very serious, which may make its comparison with normal aging of the body challenging
。

In summary, the results of this study show that the researchers have revealed the key role played by lamin in the normal aging process of the body, and the results may help researchers develop novel interventional strategies to modify this pathway as a means to
extend the health and longevity of the body.
(Biovalley Bioon.
com)

Original source:

Stanley R.
Primmer, Chen-Yu Liao,Oona M.
P.
Kummert, et al.
Lamin A to Z in normal aging, Aging (2022).
DOI: 10.
18632/aging.
204342