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Fat reduction that harms heart health!
Time of Update: 2021-08-29
In adults who are overweight or obese, have no type 2 diabetes, but have high cardiovascular risk, once-daily liraglutide treatment combined with life> .
Effects of liraglutide on visceral and ectopic fat in adults with overweight and obesity at high cardiovascular risk: a randomised, double-blind, placebo-controlled, clinical trial.
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Chinese scholars: Single gene deletion can promote the growth of functional lymphatic valves
Time of Update: 2021-08-29
Based on early USF Health's discovery of the cell signaling process that controls the formation of lymphatic vessels, Dr.
Similarly, deletion of LEC-specific Foxo1 also increased valve formation in adult mice compared with control mice without gene knockout .
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Front Pharmacol: Fenofibrate can reduce SARS-CoV-2 infection rate by up to 70%
Time of Update: 2021-08-29
In a new study, researchers from the University of Birmingham, the University of Keele, the University of Liverpool, the University of Copenhagen, Denmark, and the San Rafael Institute of Science in Italy have discovered in the laboratory a substance commonly used to treat fatty substances in the blood Abnormal levels of approved drugs can reduce infections caused by the SARS-CoV-2 virus by up to 70% .
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A study of nearly 100,000 people in the UK reveals that the infection rate of the Delta strain in the fully vaccinated population has dropped by 2/3
Time of Update: 2021-08-29
According to a report from the British Government Network on the 4th, REACT-1, one of the UK's national new coronavirus infection tracking studies, announced the latest results, saying that compared with unvaccinated people, the new crown virus infection rate of people who have completed vaccination is 1/3 of the former.
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Reduce the risk of disease progression in patients with early kidney cancer by 32%, Keytruda receives priority review qualification
Time of Update: 2021-08-29
"Reference materials:[1] FDA Grants Priority Review to Merck's Supplemental Biologics License Application for Keytruda® (pembrolizumab) as Adjuvant Therapy in Certain Patients With Renal Cell Carcinoma (RCC) Following Surgery.
Retrieved August 10, 2021, fromhttps:// AE-pembrolizumab-as-Adjuvant-Therapy-in-Certain-Patients-With-Renal-Cell-Carcinoma-RCC-Following-Surgery
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Russia develops effective drugs for the treatment of brain diseases in the elderly
Time of Update: 2021-08-29
Irina Utebova, a professor at the Department of Organic and Biomolecular Chemistry at Ural Federal University, said that one of the main causes of brain diseases in the elderly is that with age, too much amyloid structure accumulates in the brain .
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Some immune cells are better at killing cancer cells?
Time of Update: 2021-08-29
Using single-cell RNA sequencing and TCR sequencing, combined with the detection of surface proteins, they linked the phenotypic characteristics of tumor-infiltrating T cells with the antigenic specificity of their TCR .
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Overcoming international problems, a large-scale study by Chinese scholars is the first to authoritatively define the scope of lymph node dissection for esophageal cancer
Time of Update: 2021-08-29
The reporter learned on the 11th that the large-scale research conducted by the team of Professor Chen Haiquan of Thoracic Surgery of Fudan University Cancer Hospital has taken the lead in clearly defining the scope of lymph node dissection for esophageal cancer in the international academic community .
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PNAS: How to maintain the speed of cell cilia
Time of Update: 2021-08-29
Due to the high complexity and multi-scale nature of this phenomenon, the mechanical understanding of the self-organization of cilia into metachronal waves has so far been lacking .
This new model was proposed by Fanlong Meng, Rachel Bennett, Nariya Uchida, and Ramin Golestanian.
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Chinese Academy of Sciences scholars have made progress in the collaborative improvement of rice grain size and leaf angle
Time of Update: 2021-08-29
Thus, POW1-TAF2 and POW1 -BR separable modules regulatory functions in seed size and leaf angle developing compact plant design, increased thousand kernel weight yielding rice varieties provides an effective strategy .
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The first domestic gene therapy for hemophilia B was approved for clinical use
Time of Update: 2021-08-29
Recently, CDE official website revealed that a letter medicine BBM-H901 Injection get approved drugs in clinical trials, will officially launch the registration clinical trial for the prevention of bl
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Moderna: The third dose of vaccine enhances Delta's neutralization ability by 42 times, and 15 projects enter the clinic
Time of Update: 2021-08-29
▲The third dose of enhanced vaccine significantly improves the ability to neutralize the new crown variants (picture source: reference [3])The company believes that current clinical data supports the use of a dose of 50 μg of mRNA-1273 as a booster vaccine.
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Potential new standard therapy!
Time of Update: 2021-08-29
The specific main results are as follows:At week 49, the trial reached its primary endpoint of improving respiratory function .
Retrieved August 6, 2021, from https:// /06/2276588/0/en/FDA-approves-Nexviazyme-avalglucosidase-alfa-ngpt-an-important-new-treatment-option-for-late-onset-Pompe-disease.
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Innovative psoriasis topical therapy is expected to be approved by the FDA next year and will be listed in China
Time of Update: 2021-08-29
(The original text has been deleted)Reference materials:[1] Dermavant Announces FDA Acceptance for Filing of New Drug Application (NDA) for Tapinarof Cream for the Treatment of Adults with Plaque Psoriasis.
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Nature's breakthrough discovery: a unique new mechanism of human short intron splicing
Time of Update: 2021-08-28
SPF45 is a new type of essential splicing factor that acts on a subset of human short introns; a new study by researchers at Fujita Health University in Japan shows that the splicing mechanism involving this factor is different from the longer traditional splicing factor.
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Cell Research: A new generation of high-efficiency, low-toxicity tumor-restricted IL-15 prodrugs
Time of Update: 2021-08-28
On August 10, 2021, " Cell Research " magazine published online a collaborative research paper "Tumor-conditional IL-15 pro-cytokine reactivates" by researcher Peng Hua from the Institute of Biophysics of the Chinese Academy of Sciences and Professor Fu Yangxin from the University of Texas Southwestern Medical Center.
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A new method to measure the torsional stiffness of DNA
Time of Update: 2021-08-28
In "Twist Stiffness of Extended and Plectonemic DNA" published in Physical Review Letters on July 7, the researchers reported a method for measuring the torsional stiffness of DNA.
"We came up with a very clever way to measure the torsional stiffness of DNA," said senior author Michelle Wang .
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New technology identifies proteins in living brains
Time of Update: 2021-08-28
After verifying the technology using fluorescence and electron microscope imaging of the brain, the researchers found that their technology took a snapshot of all the proteins (or proteome) in living neurons, which could then be analyzed by mass spectrometry after death .
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How did the snake's fangs come from?
Time of Update: 2021-08-28
Research led by Flinders University and South Australian Museum showed that the answer lies in the special microscopic characteristics of their teeth .
Our research answers this question and shows that normal snake fangs can easily become hypodermic syringes," Fu Said Dr.
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New tumor cell tracking system
Time of Update: 2021-08-28
A team of researchers at the University of Texas at Austin has developed a new method to label tumor cells to figure out how they have evolved and changed over time to resist cancer treatments .