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New crown lambda mutant strain may escape neutralizing antibodies
Time of Update: 2021-08-29
Japanese researchers recently published an article on the US Biology Open Access Preprint Platform (BioRxiv) that the lambda (λ) variant strain of the new coronavirus is not only highly infectious, but also likely to evade neutralizing antibodies .
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Chinese scholars: Single gene deletion can promote the growth of functional lymphatic valves
Time of Update: 2021-08-29
Based on early USF Health's discovery of the cell signaling process that controls the formation of lymphatic vessels, Dr.
Similarly, deletion of LEC-specific Foxo1 also increased valve formation in adult mice compared with control mice without gene knockout .
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Fat reduction that harms heart health!
Time of Update: 2021-08-29
In adults who are overweight or obese, have no type 2 diabetes, but have high cardiovascular risk, once-daily liraglutide treatment combined with life> .
Effects of liraglutide on visceral and ectopic fat in adults with overweight and obesity at high cardiovascular risk: a randomised, double-blind, placebo-controlled, clinical trial.
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Three drugs selected for the WHO's new crown "Solidarity Test+" project
Time of Update: 2021-08-29
The World Health Organization announced on the 11th that its "Solidarity Test+" project will recruit new crown inpatients to evaluate the efficacy of artesunate, imatinib and infliximab.
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Moderna: The third dose of vaccine enhances Delta's neutralization ability by 42 times, and 15 projects enter the clinic
Time of Update: 2021-08-29
▲The third dose of enhanced vaccine significantly improves the ability to neutralize the new crown variants (picture source: reference [3])The company believes that current clinical data supports the use of a dose of 50 μg of mRNA-1273 as a booster vaccine.
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Overcoming international problems, a large-scale study by Chinese scholars is the first to authoritatively define the scope of lymph node dissection for esophageal cancer
Time of Update: 2021-08-29
The reporter learned on the 11th that the large-scale research conducted by the team of Professor Chen Haiquan of Thoracic Surgery of Fudan University Cancer Hospital has taken the lead in clearly defining the scope of lymph node dissection for esophageal cancer in the international academic community .
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PNAS: How to maintain the speed of cell cilia
Time of Update: 2021-08-29
Due to the high complexity and multi-scale nature of this phenomenon, the mechanical understanding of the self-organization of cilia into metachronal waves has so far been lacking .
This new model was proposed by Fanlong Meng, Rachel Bennett, Nariya Uchida, and Ramin Golestanian.
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Some immune cells are better at killing cancer cells?
Time of Update: 2021-08-29
Using single-cell RNA sequencing and TCR sequencing, combined with the detection of surface proteins, they linked the phenotypic characteristics of tumor-infiltrating T cells with the antigenic specificity of their TCR .
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Reduce the risk of disease progression in patients with early kidney cancer by 32%, Keytruda receives priority review qualification
Time of Update: 2021-08-29
"Reference materials:[1] FDA Grants Priority Review to Merck's Supplemental Biologics License Application for Keytruda® (pembrolizumab) as Adjuvant Therapy in Certain Patients With Renal Cell Carcinoma (RCC) Following Surgery.
Retrieved August 10, 2021, fromhttps:// AE-pembrolizumab-as-Adjuvant-Therapy-in-Certain-Patients-With-Renal-Cell-Carcinoma-RCC-Following-Surgery
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Chinese Academy of Sciences scholars have made progress in the collaborative improvement of rice grain size and leaf angle
Time of Update: 2021-08-29
Thus, POW1-TAF2 and POW1 -BR separable modules regulatory functions in seed size and leaf angle developing compact plant design, increased thousand kernel weight yielding rice varieties provides an effective strategy .
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Potential new standard therapy!
Time of Update: 2021-08-29
The specific main results are as follows:At week 49, the trial reached its primary endpoint of improving respiratory function .
Retrieved August 6, 2021, from https:// /06/2276588/0/en/FDA-approves-Nexviazyme-avalglucosidase-alfa-ngpt-an-important-new-treatment-option-for-late-onset-Pompe-disease.
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Russia develops effective drugs for the treatment of brain diseases in the elderly
Time of Update: 2021-08-29
Irina Utebova, a professor at the Department of Organic and Biomolecular Chemistry at Ural Federal University, said that one of the main causes of brain diseases in the elderly is that with age, too much amyloid structure accumulates in the brain .
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The first domestic gene therapy for hemophilia B was approved for clinical use
Time of Update: 2021-08-29
Recently, CDE official website revealed that a letter medicine BBM-H901 Injection get approved drugs in clinical trials, will officially launch the registration clinical trial for the prevention of bl
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Innovative psoriasis topical therapy is expected to be approved by the FDA next year and will be listed in China
Time of Update: 2021-08-29
(The original text has been deleted)Reference materials:[1] Dermavant Announces FDA Acceptance for Filing of New Drug Application (NDA) for Tapinarof Cream for the Treatment of Adults with Plaque Psoriasis.
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New research reveals unexpected function of spine motor network
Time of Update: 2021-08-28
What does the research show?"In this study, we determined the direct role of spinal cord motor neurons in activating spinal cord stem cell populations, which can produce glial cells of new neurons in adult zebrafish .
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After "plant meat" is on the market, scientists look forward to "cell-based seafood" made from fish cells
Time of Update: 2021-08-28
In this new study, 1,200 representative consumers evaluated Atlantic salmon on the package, which was designed to mimic the salmon in the grocery store and labeled "cell-based seafood" or "cell-cultured seafood" "Tag .
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Innovative antisense nucleotide therapy across the blood-brain barrier is expected to revolutionize the treatment of neurodegenerative diseases
Time of Update: 2021-08-28
A few days ago, researchers from Tokyo Medical and Dental University (TMDU), Ionis Pharmaceuticals, and Takeda Corporation have discovered a new method to deliver ASO subcutaneously or intravenously across the blood-brain barrier to the central nervous system .
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Kesha's research group has made important progress in the study of protein phase separation mechanism in single molecule technology
Time of Update: 2021-08-28
This study uses single-molecule fluorescence technology to reveal the dynamic changes in the conformation of Tau protein during the liquid-liquid phase separation process and the molecular mechanism related to the occurrence of irreversible amyloid aggregation .
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A new method to measure the torsional stiffness of DNA
Time of Update: 2021-08-28
In "Twist Stiffness of Extended and Plectonemic DNA" published in Physical Review Letters on July 7, the researchers reported a method for measuring the torsional stiffness of DNA.
"We came up with a very clever way to measure the torsional stiffness of DNA," said senior author Michelle Wang .
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Where is the treatment for peripheral T-cell lymphoma of BMS and Takeda?
Time of Update: 2021-08-28
Subsequently, BMS carried out a confirmatory phase III clinical trial to evaluate romidepsin+CHOP (Ro-CHOP) and CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) in the first-line treatment of PTCL The efficacy in patients, but did not reach the primary efficacy endpoint of progression-free survival .
