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Immune T cells rely on T cell receptors (TCR) on the surface to recognize and attack viruses and abnormal cells in the body, such as cancer cells
In a recent research paper published in the journal Nature, Professor Catherine Wu and his colleagues at the Dana-Farber Cancer Institute and Broad Institute elaborated on the behavior of T cells and their surface The relationship between TCR characteristics
In this study, scientists analyzed biopsy samples and peripheral blood samples from multiple melanoma patients
The analysis results pointed out that the tumor-specifically shaped the expression state of infiltrating T cells
▲Different melanoma patients have different clinical course and treatment methods.
According to the information provided by TCR, tumor-infiltrating T cells in a depleted state include not only T cells that specifically recognize over-expressed melanoma antigens (that is, tumor antigens shared by different tumors), but also include targeted recognition of individualized tumors Neoantigens (ie antigens unique to each tumor) T cells
The high level of such tumor infiltrating depleted T cells in the blood circulation is directly related to the continued disease state of the patient
Note: The original text has been deleted
Reference materials:
[1] Oliveira G, et al.
[2] What makes some immune cells better at killing melanoma.
