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Kesha's research group has made important progress in the study of protein phase separation mechanism in single molecule technology
Time of Update: 2021-08-28
This study uses single-molecule fluorescence technology to reveal the dynamic changes in the conformation of Tau protein during the liquid-liquid phase separation process and the molecular mechanism related to the occurrence of irreversible amyloid aggregation .
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Nature's breakthrough discovery: a unique new mechanism of human short intron splicing
Time of Update: 2021-08-28
SPF45 is a new type of essential splicing factor that acts on a subset of human short introns; a new study by researchers at Fujita Health University in Japan shows that the splicing mechanism involving this factor is different from the longer traditional splicing factor.
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Innovative antisense nucleotide therapy across the blood-brain barrier is expected to revolutionize the treatment of neurodegenerative diseases
Time of Update: 2021-08-28
A few days ago, researchers from Tokyo Medical and Dental University (TMDU), Ionis Pharmaceuticals, and Takeda Corporation have discovered a new method to deliver ASO subcutaneously or intravenously across the blood-brain barrier to the central nervous system .
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New research reveals unexpected function of spine motor network
Time of Update: 2021-08-28
What does the research show?"In this study, we determined the direct role of spinal cord motor neurons in activating spinal cord stem cell populations, which can produce glial cells of new neurons in adult zebrafish .
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Mustang Bio and Miaoyou Medical International reach a cooperation that is expected to break the bottleneck of cell therapy
Time of Update: 2021-08-28
This technology will be used to change the manufacturing method of chimeric antigen receptor T cell (CAR-T) therapy, and may be used as a "ready-to-use" therapy, which has the potential to be applied to any tumor target .
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Nature Sub-Journal: DNA-based data structure system
Time of Update: 2021-08-28
The team, led by researchers from the School of Computer Science at Newcastle University, has created a new dynamic DNA data structure that can store and recall information from DNA molecules in an orderly manner .
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Use MOA-seq to map maize genome regulation switch
Time of Update: 2021-08-28
In their proof-of-concept study using corn ears, they demonstrated that their experiment, using micrococcal nuclease (MNase) as a structural probe, can detect known transcription factor (TF) binding sites .
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Navigating the corn maze: a "optical switch" technology for mapping the corn genome
Time of Update: 2021-08-28
Hank Bass, professor of biological sciences, said: “The understanding of genome structure should help focus genome editing and accelerate larger-scale applied research, such as guiding research in precision agriculture and medicine .
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Reactivation of protective p53 anti-cancer target eIF4A3 debut
Time of Update: 2021-08-28
(Source: Science Advances)Studies have also shown that deletion of eIF4A3 disrupts the process of RiBi, thereby altering the production of proteins in cancer cells .
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CRISPR gene editing technology brings new insights into hypertrophic cardiomyopathy
Time of Update: 2021-08-28
A paper published in the Proceedings of the National Academy of Sciences (PNAS) and by Beth Pratt, Professor of Mechanical Engineering at the University of California, Santa Barbara and Director of the Campus Bioengineering Institute, describes the results of a complex long-term collaboration, including Stanford University researchers at the University of Washington and the University of Kentucky .
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Nature Genetics discovers a new genetic mutation that causes high blood pressure in pregnant women
Time of Update: 2021-08-28
Bartholomew's Hospital found that a pair of unique genetic mutations can cause sudden onset of high blood pressure in pregnant women .
Bartholomew’s Hospital has discovered many genetic variants that cause small adrenal nodules to produce high levels of aldosterone .
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The Wang Linqi research group of the Institute of Microbiology was invited to publish a review paper on fungal quorum sensing in the Annual Review of Microbiology
Time of Update: 2021-08-28
The composition, function and mechanism of the quorum sensing system of a model fungus [such as virulence (Figure 2)], and the important biological processes that the fungal quorum sensing system participates in the regulation of fungi/eukaryotes .
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The bizarre hadrons accurately predicted by Professor Shilin Zhu’s group of the School of Physics in 2012 were discovered for the first time in experiments
Time of Update: 2021-08-28
9" >Recently, the CERN Large Hadron Collider Bottom Quark Detector (LHCb) experimental group announced at the European Physical Society’s High Energy Physics Conference (EPS-HEP) that it has detected two charm quarks, an anti-up quark and one Reverse the four-quark state TCC+ of the down quark, thus confirming the bicharm strange hadron state composed of DD* meson predicted in 2012 by Professor Shilin Zhu and collaborators of the School of Physics .
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Lu Yingli's team from Shanghai Jiaotong University publishes original clinical research results in international journals
Time of Update: 2021-08-28
The results show that long-term and frequent nightlife and work significantly increase the risk of atrial fibrillation and coronary heart disease, revealing that the rhythm of life disorder, especially nightlife and work, may be The new risk factors of atrial fibrillation and coronary heart disease provide important public health and clinical guidance for paying attention to and improving the cardiovascular health of the population .
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Science: The missing link between high-fat diet, microbiota and heart disease
Time of Update: 2021-08-28
Mariana Byndloss and Woongjae Yoo are exploring the link between diet, gut microbes and heart diseaseA study published in the journal Science on August 13 shows that a high-fat diet destroys the biological properties of the intestinal lining and its microbial community, and promotes the production of a metabolite that may cause heart disease .
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Targeting mitochondria is expected to treat obesity
Time of Update: 2021-08-28
Our research uses a small molecule to simultaneously reshape mitochondria in multiple tissues, reverse obesity and correct metabolic diseases, even if mice continue to eat an unhealthy diet," said UCI principal researcher, professor of development and cell biology, and senior author Aimee Edinger .
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Where is the treatment for peripheral T-cell lymphoma of BMS and Takeda?
Time of Update: 2021-08-28
Subsequently, BMS carried out a confirmatory phase III clinical trial to evaluate romidepsin+CHOP (Ro-CHOP) and CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) in the first-line treatment of PTCL The efficacy in patients, but did not reach the primary efficacy endpoint of progression-free survival .
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Chinese scholars and overseas collaborators have made progress in burrowing convergence and spine evolution and development in Mesozoic mammals
Time of Update: 2021-08-28
Under this developmental mechanism, the ecological habits and biomechanical requirements of species in order to adapt to natural selection have produced the diversity of mammalian body trunks .
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Zhang Pingwen, Zhang Lei and collaborators published a review paper on "Modeling and Calculation of Liquid Crystals"
Time of Update: 2021-08-28
9" >On August 4, 2021, Professor Zhang Pingwen of the School of Mathematical Sciences of Peking University and Director of the National Engineering Laboratory of Big Data Analysis and Applied Technology, Associate Professor Zhang Lei of Beijing International Mathematical Research Center and Researcher Wang Wei of the School of Mathematical Sciences of Zhejiang University, published in Acta Numerica A review paper entitled " Modelling and Computation of Liquid Crystals " .
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Contraceptive antibodies are here!
Time of Update: 2021-08-28
In a new study published in Science Translational Medicine on August 11, the research team introduced an antibody that recognizes human sperm-specific antigens that can bind to and capture over 99% of human sperm in the vagina of sheep .