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Nature's breakthrough discovery: a unique new mechanism of human short intron splicing

 Last Update: 2021-08-28
 Source: Internet
 Author: User

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SPF45 is a new type of essential splicing factor that acts on a subset of human short introns; a new study by researchers at Fujita Health University in Japan shows that the splicing mechanism involving this factor is different from the longer traditional splicing factor.

Protein coding genes carry the blueprint for protein production

The length of human pre-mRNA introns varies greatly, ranging from less than 50 nucleotides to more than 1 million nucleotides (nt)

Now, a research team led by Professor Akila Mayeda of the Institute of Comprehensive Medical Sciences at Fujita Health University in Japan is trying to answer this question in the latest research published in Nature Communications

The research team first searched for the necessary factors for splicing human short introns from 154 human nucleoproteins

In HNRNPH1 pre-mRNA with 56-nt intron, the strongest splicing inhibition was caused by SPF45 knockdown, while splicing inhibition was not observed in HNRNPH1 pre-mRNA with control 366-nt intron

Next, the researchers investigated the factors that determine the spf45 dependence of certain short introns

Previously, it has been reported that SPF45 acts as a regulator of alternative splicing; however, SPF45 is also an important factor for cell survival and maintenance in vivo

Professor Mayeda said: "This is a breakthrough achievement in the field of basic research

Original reference:

Title of original paper: SPF45/RBM17-dependent, but not U2AF dependent, splicing in a distinct subset of human short introns

Journal: Nature Communications

DOI: https://doi.

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