Nature Sub-Journal: Children's MISC complications may be caused by T cell failure

With the increase of delta mutations, children under the age of 12 cannot receive the vaccine, and a deeper understanding of children's multiple system inflammatory syndrome (misc) is essential
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Misc is a rare but serious complication that occurs in some children several weeks after being infected with SARS-CoV-2

This research was published in the journal Nature Communications today and is entitled " Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children "
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"Our study shows that T cell failure in misc patients is one of the potential drivers of this disease, indicating that the increase in NK cells and circulatory failure CD8+ T cells may improve the symptoms of inflammatory diseases," Noam Beckmann, the main co-author of the study The doctor said that he is an assistant professor of genetics and genomic sciences
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Member of the Mount Sinai Clinical Information Center (MSCIC), Icahn School of Medicine, Mount Sinai

Misc is characterized by fever, pain, and inflammation of multiple organs, including the heart, lungs, kidneys, skin, eyes, or gastrointestinal tract

The team performed RNA sequencing on the blood of misc patients (and the control group) to discover disease-related genes "clustered in the co-expression module of CD56dimCD57+ natural killer (NK) cells and depleted CD8+ T cells
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" The authors write that similar transcriptome features were also found in a separate cohort of Kawasaki disease (a related disease originally named by misc)

Through the gene expression research of the Mount Sinai team, the researchers have taken an important step and provided a new way to explore in this field, involving their construction from the pediatric cases of misc and COVID-19 in the COVID-19 biobank at Mount Sinai.
Complex gene networks and sub-networks
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One of the more important gene networks involves the suppression of two types of immune cells: NK cells and CD8+ T cells
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Previous studies have shown that when CD8+ T cells are continuously exposed to pathogens, they will enter a state of "exhaustion", resulting in loss of their proliferation efficiency and ability

Beckmann added that one of the regulatory factors, TBX21, is a promising therapeutic target because it plays a major coordinating role in the transition from effective to depleted CD8+ T cells
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Mount Sinai Hospital’s work on misc is the first gene expression study of the hospital’s COVID-19 biobank
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The warehouse was created by a volunteer team of more than 100 nurses, doctors and researchers, and is the backbone of the rapidly expanding COVID-19 research on Mount Sinai