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Responding to Actively Receiving Vaccines from Different Technical Routes of Variant Strains
Ask about the new crown vaccine
◎Reporter Zhang Jiaxing
Recently, variants of the new crown virus, Delta and Lambda, have appeared one after another
Up to now, the vaccines approved for marketing and emergency use have been proven by scientific research to still be effective against mutant strains
A recent study by the Grossman School of Medicine of New York University on the effect of mRNA vaccines on lambda mutant strains showed that the number of antibodies produced by the vaccine was greatly reduced, but it still showed effectiveness
Just in case, all vaccine research and development teams, such as the Academy of Military Sciences, the Chinese Academy of Sciences, and related companies, are continuously paying attention to virus mutations and developing new vaccines
"New Generation" Vaccines Have a Recruitment "Treasure Book"
"The first step is to optimize the antigen
This turned out to be a universal book! All vaccine technical routes that need to be designed can be used
Is the vaccine of Academician Chen Wei's team? Yes
Being able to design means that it can be "operated" at the molecular level
What's the operation? The DNA recombination technology, reverse vaccinology technology, and polysaccharide protein binding technology, which were born in the 20th century, enabled the "new generation" of vaccines to be "powerful" through genomics and bioinformatics methods
Specifically, once the variant sequence is decoded, each research team can dig out valuable information in the genome, and rely on past accumulation to redesign and optimize the sequence of the vaccine
"The subsequent work is the same as when the vaccine was originally developed.
It can be seen that the new vaccine only needs to "retake the first step of design", and screening, animal testing and other work can be promoted on the established platform
Earlier, a person in charge of an mRNA vaccine research and development company told a reporter from Science and Technology Daily that using molecular biology techniques, as long as the sequence of the mutant virus strain is available (no need to cultivate the virus, only sequence information), it can be completed in 4-6 weeks.
Traditional vaccines take over, and respond calmly
Traditional inactivated vaccines, which are different from the "new generation" vaccines, are the most widely used in my country.
Inactivated vaccines have their own "collection".
Inactivated vaccines need to first obtain a mutated new coronavirus strain and screen for vaccine strains
Due to technological innovation, Sinopharm, China Biotech and other companies have mastered patented technologies such as "one-step inactivation method" and "high-density cultivation"
.
The stunt is in hand, and the response is calm
.
"There is no need to change the entire production process.
You only need to invest the cultivated mutant strain at the feeding end.
After a production cycle, a new vaccine against the mutation will be produced
.
" Shao Yiming said, as long as the test data and research results show that the vaccine should be updated, China Have the ability to update in time and provide it on a large scale quickly
.
In response to the mutation of the new coronavirus, in addition to the development of new vaccines, vaccination strategies also play a very important role
.
For example, vaccinated with booster shots, greeted more antibodies to show up, and can also fight against the new coronavirus that has transformed itself
.
Moreover, our country uses a wide range of inactivated vaccines, which allow many active ingredients to enter the body during vaccination, which has a broad spectrum.
The more people are vaccinated, the stronger the immune barrier
.