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Ouyangbo group reveals a new mechanism for metformin to regulate PD-L1 degradation
Time of Update: 2021-09-03
TRS_Editor A{font-family:;font-size:12pt;}</> On August 24, the international academic journal Nature Communications published online the research results of Ouyang Bo’s research group at the Center for Excellence in Molecular Cell Science (Institute of Biochemistry and Cell Biology) of the Chinese Academy of Sciences “PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain" .
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A new gene related to male infertility: ZFP541
Time of Update: 2021-09-03
After the function of the mouse ZFP541 gene was eliminated by genome editing, male germ cells began to meiosis, but died because they did not produce sperm, leading to infertility .
These results indicate that ZFP541 and HDAC1 together eliminate histone acetyl groups, inactivate the expression of meiosis-related genes, and complete meiosis .
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Breaking through the limitations, Zhejiang University researchers develop single-molecule electrochemiluminescence microscopy imaging methods
Time of Update: 2021-09-03
Inspired by fluorescence super-resolution microscopy (Nobel Prize in Chemistry in 2014), the research team used spatially isolated molecular reaction positioning information to perform optical reconstruction imaging, and for the first time achieved electrochemiluminescence imaging that broke the optical diffraction limit .
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Determination of the key molecular mechanisms affecting the severity of new coronary pneumonia
Time of Update: 2021-09-03
According to this study, 63% of patients with new coronary pneumonia whose sPLA2-IIA enzyme level is equal to or greater than 10 nanograms per milliliter are fatal .
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"Science" publishes an article to demonstrate the animal origin of the new coronavirus
Time of Update: 2021-09-03
The paper believes that the emergence of the new coronavirus has characteristics consistent with natural spillovers, and the possibility of human manipulation by the Wuhan Institute of Virology is extremely small .
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Chinese scholars have made progress in the selective CH functionalization of aromatic sites
Time of Update: 2021-09-03
The adjustment of the three-dimensional space of chiral phosphoric acid is as follows: The activation and asymmetry control of the distal sites of the benzene ring provide opportunities (Figure) .
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How much does PM2.5 reduce people's life span?
Time of Update: 2021-08-29
The transformation of the energy structure and the optimization of the economic structure have also contributed significantly to the improvement of air pollution, avoiding the risk of premature death of 720,000 people in total .
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Daan Gene: Obtained two medical device registration certificates
Time of Update: 2021-08-29
On the 9th, Daan Gene announced that it has obtained two medical device registration certificates issued by the State Drug Administration .
Chlamydia trachomatis nucleic acid detection kit (PCR-fluorescent probe method), registration number: National Machinery Note 2013400572 .
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The infectious power is comparable to chickenpox "Delta". Why is it so poisonous?
Time of Update: 2021-08-29
Rochelle Varensky, director of the US Centers for Disease Control and Prevention (CDC), said that new research shows that people who have been infected with the Delta strain and also vaccinated carry a lot of the virus in their noses and throats .
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6 admissions!
Time of Update: 2021-08-29
Related research was published in Science Advances with the title The major mechanism of melanoma mutations is based on deamination of cytosine in pyrimidine dimers as determined by circle damage sequencing .
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Two articles use organoids + chips to reveal how bacteria invade the bladder
Time of Update: 2021-08-29
In the bladder model on a complementary chip, the researchers observed the growth dynamics of the bacterial community in the cell over time .
Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection .
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Spatial transcriptomics reveals the microstructure and insulin response of adipocytes
Time of Update: 2021-08-29
, Professor and Senior Advisor of Harding School of Medicine, Karolinska Institute [Source: Ulf Sirborn]"In contrast, our research shows that insulin resistance, which may be type 2 diabetes, may be due to changes in a specific subtype of fat cells .
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Nature: BATF combined with IRF4 to combat tumor-infiltrating CAR-T cell failure
Time of Update: 2021-08-29
However, studies have shown that in CD8+ T cells expressing chimeric antigen receptors (CAR), overexpression of BATF promotes the survival and expansion of tumor-infiltrating CAR-T cells, increases the production of effector cytokines, and inhibits the receptor and The expression of the depletion-related transcription factor TOX is reduced, which supports the generation of long-lived memory T cells and can control tumor recurrence .
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New strategy helps fight bacterial sepsis
Time of Update: 2021-08-29
Recently, researchers from the University of Tübingen in Germany have developed a new experimental strategy to prevent and treat bacterial sepsis: instead of using antibiotics, acetate is used as the active ingredient to stimulate the body's own immune system .
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The microbiota of young mice can improve cognitive function of elderly recipients
Time of Update: 2021-08-29
By transplanting fecal microbes from young mice to older mice, the researchers were able to reverse the differences associated with aging and slow down cognitive impairment .
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NEJM: Monoclonal antibodies can prevent malaria
Time of Update: 2021-08-29
This NIAID trial tested whether a neutralizing monoclonal antibody called CIS43LS can safely provide a high level of protection against malaria for American adults, provided that they have been carefully and voluntarily exposed to infected mosquitoes in the laboratory.
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Front Pharmacol: Fenofibrate can reduce SARS-CoV-2 infection rate by up to 70%
Time of Update: 2021-08-29
In a new study, researchers from the University of Birmingham, the University of Keele, the University of Liverpool, the University of Copenhagen, Denmark, and the San Rafael Institute of Science in Italy have discovered in the laboratory a substance commonly used to treat fatty substances in the blood Abnormal levels of approved drugs can reduce infections caused by the SARS-CoV-2 virus by up to 70% .
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Israel cures 90% of severely ill patients with new coronary disease within 5 days of researching new drug
Time of Update: 2021-08-29
Recently, Israel’s "Jerusalem Post" reported that the second phase of the clinical trial of the new anti-coronary pneumonia drug "EXO-CD24" developed by the team of Professor Nadir Alber from Izirov Hospital in Israel has again achieved positive results, with more than 90% of participation The critically ill patient in the experiment was cured and discharged within 5 days .
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PLoS Biol: Revealing the mechanism of natural killer cells from destroying perforin released by themselves
Time of Update: 2021-08-29
In a new study, researchers from Columbia University in the United States revealed a newly discovered fat "shield" that prevents natural killer cells (NK cells) from being destroyed by their own lethal biological weapons, and also allows some cancer cells to evade Attack of the immune system .
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Three drugs selected for the WHO's new crown "Solidarity Test+" project
Time of Update: 2021-08-29
The World Health Organization announced on the 11th that its "Solidarity Test+" project will recruit new crown inpatients to evaluate the efficacy of artesunate, imatinib and infliximab.
