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BATF may improve the anti-tumor response of CAR-T cells by deviating the phenotype and transcription profile of CAR-T cells to enhance their effector functions
When CD8+ T cells encounter antigens and effective costimulatory signals, they will produce a strong response to eliminate pathogen-infected cells and tumor cells
Recently, Professor Hyungseok Seo and his team have carried out research on CAR-T cells, proving that over-expressed BATF can cooperate with IRF4 to combat the development of T cell failure
The researchers injected B16F0-hCD19 tumor cells into the previous five mice and used five age-matched C57BL/6 mice as a control group
Frequency of CAR-T cells in spleen cells and draining lymph nodes (dLN) of C57BL/6 mice
In view of these data, the researchers put forward a hypothesis: whether the co-expression of IRF4 and BATF will further improve the anti-tumor response of CD8+TILs
In short, both BATF and IRF4 are induced by TCR activation.
