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Ouyangbo group reveals a new mechanism for metformin to regulate PD-L1 degradation

 Last Update: 2021-09-03
 Source: Internet
 Author: User

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Programmed cell death ligand 1 (PD-L1) is a ligand molecule highly expressed on the surface of tumor cells.

Immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway have achieved great success in recent years

In this study, the researchers used nuclear magnetic resonance and biochemical techniques to first find that the N-terminal of PD-L1-CD will adhere to the membrane in the presence of acidic phospholipids

Assistant researcher Wen Maorong, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Master Cao Yunlei, and Dr.

Article link: https://

Schematic diagram of acidic phospholipids regulating the interaction of PD-L1-CD with membranes and affecting PD-L1 degradation

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