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The deubiquitinase USP7 is a novel cyclin F interaction protein that regulates the stability of cyclin F
Time of Update: 2023-01-05
"In conclusion, in this study, we demonstrate a new interacting partner of cyclin F, USP7, and the role of USP7 in cyclin F mRNA and protein regulation.
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Production of "DNA virus vaccines" to fight DNA viruses
Time of Update: 2023-01-05
Rutgers scientists have developed a new way to stop viral infections: a so-called live, replicated, defective DNA virus vaccine that uses a compound called centanamycin to create a mutated virus for vaccine development.
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Kunming Plant has made important progress in the biosynthesis of cocaine, a botanical drug
Time of Update: 2023-01-05
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A new standard for first-line treatment of prostate cancer (mCRPC)! PARP inhibitor + new hormone therapy combination regimen Lynparza + Zyetiga is about to be approved in Europe and the United States!
Time of Update: 2023-01-05
Nov. 16, 2022 /Biovalley BIOON/ -- AstraZeneca and Merck & Co have announced that the European Medicines Agency (EMA) Committee on Medicinal Products for Human Use (CHMP) has issued a positive review recommending the approval of the PARP inhibitor-like anticancer drug Lynparza (Chinese brand name: Lipzo, generic name: olaparib, Olaparib): a combination of abiraterone and prednisone or prednisolone for the treatment of adult patients with metastatic castration-resistant prostate cancer (mCRPC) who are not clinically amenable to chemotherapy.
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Cell sub-issue: Development of a live-in attenuated DNA virus vaccine against DNA virus infection
Time of Update: 2023-01-05
The authors say that developing a method that can quickly and easily produce a live attenuated virus with replication defects will accelerate vaccine development against diseases caused by DNA viruses.
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The discovery of this "selfish" gene casts doubt on established evolutionary beliefs
Time of Update: 2023-01-05
"The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years The discovery could change our understanding of how parasitic DNA affects genome evolution.
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The latest research shows that the SARS-CoV-2 spike protein is no longer the only target
Time of Update: 2023-01-05
Francesco Luigi Gervasio, the last author of the study, said: "These results pave the way for the development of new treatments against the Nsp1 protein, not only SARS-CoV-2 and its variants, but also other coronaviruses where Nsp1 is present.
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Science: Chinese scientists revealed the mechanism of spindle assembly without centrosomes in human oocytes
Time of Update: 2023-01-05
These findings suggest that human oocytes have evolved a different initiation mechanism for microtubule nucleation and spindle assembly.
These findings suggest that human oocytes have evolved a different initiation mechanism for microtubule nucleation and spindle assembly.
com)Resources:Tianyu Wu et al.
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"Nature" Chinese scientists isolated a bacterium that can decompose nicotine in the intestines of mice
Time of Update: 2023-01-05
In the new study, the researchers found that a specific bacterium can break down nicotine in the gut of mice (due to forced smoking), reducing the likelihood of fatty liver disease.
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Genomic Medicine: Understanding the aggressiveness of lung squamous cell carcinoma through the tumor stroma
Time of Update: 2023-01-05
1186/s13073-022-01127-6 Scientists at the Gavin Institute of Medical Research in Australia have identified a molecular profile of the surrounding stroma of a common subtype of lung cancer, which promises to indicate which patients are likely to progress to aggressive tumors.
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A new method for synthesizing messenger RNA
Time of Update: 2023-01-05
Molecular Therapy - Nucleic Acids, 2022; 30: 300 A team of synthetic biologists at the Hong Kong University of Science and Technology (HKUST) recently discovered a way to increase the efficiency of protein production of synthetic mRNA by up to 10 times, meaning that with fewer mRNA doses, the effectiveness of mRNA vaccines and drugs used to treat cancer, Covid-19 or other genetic diseases can be greatly improved.
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Immune cells in patients with amyotrophic lateral sclerosis can predict the course of the disease
Time of Update: 2023-01-04
1038/s41467-022-34526-9 According to a study published in Nature Communications by the Karolinska Institutet, when diagnosing ALS, by measuring immune cells in the cerebrospinal fluid, it is possible to predict the rate of disease progression.
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Brain markers for ADHD in children
Time of Update: 2023-01-04
The researchers analyzed MRI data from nearly 8,000 children and found biomarkers for attention-deficit/hyperactivity disorder (ADHD) and the possible role of neuroimaging machine learning in helping diagnose, plan and monitor the disorder.
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Research has revealed a link between oral bacteria and disease
Time of Update: 2023-01-04
Improve diagnosis and treatmentThe study used 1,014 samples from the same number of patients (469 women and 545 men) and used a mass spectrometry analysis method called MALDI-TOF, which can quickly identify individual live bacteria in a sample but is rarely used for dental care.
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The research results of Professor Luo Li's team of our institute, "Systematic Construction Strategy of Normalized Prevention and Control of New Coronary Pneumonia Epidemic and Public Health Emergency Management System", won the first prize of Shanghai Decision Consulting Research Achievements
Time of Update: 2023-01-04
The research results of Professor Luo Li's team of our institute "Systematic Construction Strategy of Normalized Prevention and Control of the New Crown Pneumonia Epidemic and Public Health Emergency Management System" won the first prize.
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Nature sub-issue: Novel nanoparticles provide innovative cancer chemotherapy immunotherapy
Time of Update: 2023-01-04
"There are two innovative aspects of our study: the discovery of a new therapeutic target and a new nanocarrier that is very effective in the selective delivery of immunotherapy and chemotherapy drugs," said senior author Song Li, professor of pharmacy at the Pitt School of Pharmacy and researcher at UPMC Hillman Cancer Center.
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An existing drug can disrupt the replication of coronaviruses
Time of Update: 2023-01-04
"One of the main outcomes of treating with this drug is that it inhibits the ability of the virus to make large amounts of spike proteins and merge them into new daughter viruses or juveniles, so the resulting juveniles do not have spikes and therefore cannot cause infection," said Dr. McCormick, a virologist in the Department of Microbiology and Immunology at the Dahl College.
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The role of snoRNP in thermospermine-mediated Arabidopsis thaliana growth and development was found to be found in the study
Time of Update: 2023-01-01
A working model of T-SPM regulating Arabidopsis thaliana growth and development Polyamines are widely found in bacteria, yeast, animals and plants.
A working model of T-SPM regulating Arabidopsis thaliana growth and development Polyamines are widely found in bacteria, yeast, animals and plants.
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Adults living in areas with high levels of air pollution are more likely to suffer from multiple long-term health problems
Time of Update: 2023-01-01
A new UK study of 364,000 people shows that exposure to traffic-related air pollution increases the likelihood of multiple long-term physical and mental health problems.
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JCO: Dosage reduced by 90%, efficacy doubled! PD-1 inhibitors work better with this regimen
Time of Update: 2023-01-01
5 of the normal dose based on the body weight of a 60 kg patient, and such a low dose of nivolumab combined with beat chemotherapy could improve the one-year survival rate of HNSCC patients receiving palliative care from 16.
