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Researchers at Karolinska Institute discovered the most common bacteria
found in severe oral infections.
Few people have done such studies before, and now the team hopes the study will provide a deeper understanding
of the link between oral bacteria and other diseases.
The study was published in
Microbiology Spectroscopy.
Previous research has shown clear links
between oral health and common diseases such as cancer, cardiovascular disease, diabetes and Alzheimer's disease.
However, few longitudinal studies have determined which bacteria occur in the infected oral and maxillofacial regions
.
Researchers at Karolinska Institute have now analyzed samples collected from patients with severe oral infections at Karolinska University Hospital in Sweden between 2010 and 2020 and have a list of
the most common bacteria.
This is a collaborative study
conducted by the research group of Professor Margaret Chen and Professor Volkan zenci.
Professor Sllberg Chen, from the Department of Stomatology at Karolinska Institutet, said: "Here we have reported for the first time the microbial composition
of bacterial infection in samples collected from Stockholm County over 10 years.
" "The results show that several bacterial infections associated with systemic diseases have persisted, some of which have even increased
in Stockholm over the past decade.
"
Studies have shown that the most common bacterial phylums in the samples are Firmicutes, Bacteroides, Proteobacteria, and Actinomycetes, and the most common genera are Streptococcus, Prevosiella, and Staphylococcus
.
Professor Söllberg Chen said: "Our findings provide new insights
into the diversity and prevalence of harmful microorganisms in oral infections.
" "This finding is not only important for dental medicine, it also helps us understand the role of
tooth infections in patients with underlying conditions.
" If a certain bacterium becomes infected and causes damage in the mouth, it is likely to be harmful
to tissues in other parts of the body as the infection spreads.
”
The team has previously shown that the presence of oral bacteria in the pancreas reflects the severity
of pancreatic tumors.
The study used 1,014 samples from the same number of patients (469 women and 545 men) and used a mass spectrometry analysis method called MALDI-TOF, which can quickly identify individual live bacteria in a sample but is rarely used for dental care
.
"Our study is a single-center epidemiological study, and to ensure the validity of the results, we need to conduct more and larger studies," said
Volkan Zenci of the Department of Laboratory Medicine at Karolinska Institutet.
"We now hope that dentists will work with clinical microbiology laboratories to better understand the bacteria that cause dental infections and improve the diagnosis and treatment management
of oral infections.
"
The research was part of Khaled Al-Manei's doctoral dissertation, and his next step is to conduct similar epidemiological studies of oral fungal infections, aiming to identify new fungi and microbes and understand what causes their possible malignancies
.
The study was funded
by the Swedish Research Council, the Swedish Cancer Society and the Centre for Innovative Medicine.
