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Hong Kong University of Science and Technology: A new method that can increase the efficiency of protein production for synthesizing mRNA by a factor of 10
Time of Update: 2023-01-05
Source: The Hong Kong University of Science and TechnologyA team of synthetic biologists at the Hong Kong University of Science and Technology (HKUST) recently discovered a way to increase the efficiency of protein production of synthetic mRNA by a factor of 10, meaning that mRNA vaccines and drugs used to treat cancer, Covid-19 or other genetic diseases can be greatly improved with fewer mRNA doses.
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Science publishes an article by faculty members of Peking University's School of Medical Humanities: "China's Personal Information Protection Law: Impact on Research"
Time of Update: 2023-01-05
On November 18, 2022, Science published Xiaojie Li (first author), Associate Professor Liu Ruishuang and Professor Cong Yali (co-author) of the School of Medical Humanities of Peking University and t
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The first evidence: drug-resistant bacteria can spread from the gut to the lungs
Time of Update: 2023-01-05
These findings highlight the importance of clearing AMR bacteria from the intestinal flora of hospitalized patients, even if they do not cause infection," said Professor Craig MacLean from the Department of Biology.
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The genetic mutation that causes autism has been found to overstimulate brain cells
Time of Update: 2023-01-05
Scientists trying to understand the underlying brain mechanisms of autism spectrum disorder have discovered that a genetic mutation known to be associated with the disorder causes overstimulation of brain cells to a much greater extent than neuronal cells that are not mutated.
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Hydrogel culture bacterial system
Time of Update: 2023-01-05
Soft hydrogel-shell confinement systems as bacteria-based bioactuators and biosensors Image: Yoon Jeong (left) and Joseph Irudayaraj have developed a novel alginate hydrogel to act as a bioreactor.
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The discovery could lead to new drugs that block proteins that cause bowel cancer
Time of Update: 2023-01-05
The researchers believe that "domains" — specific regions in proteins associated with different functions — that allow tankyrases to assemble and break down into different structures are exciting targets for future cancer drugs.
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Chinese scholars have made progress in the research of silver-copper nanoclusters
Time of Update: 2023-01-05
Figure Magnetic changes in the assembly and unassembly of ag77Cu22 clusters With the support of the National Natural Science Foundation of China (approval numbers: 21925303, 21771186, 91961204, 22171
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A garbage treasure in cancer research
Time of Update: 2023-01-05
In this new research perspective, researchers use metagenomics tools to explore genomic cancer data; We used additional annotations to explore differentially expressed ncRNAs in miRNA experiments and also investigated variation in neighboring tumor samples in RNA-seq experiments.
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Science Advances: Pocket features common to deadly coronaviruses can be used for pan-coronavirus antiviral treatments
Time of Update: 2023-01-05
Researchers at the University of Bristol, led in the study, published in Scientific Advances, say their findings could lead to the development of a pan-coronavirus treatment to defeat all coronaviruses – from the SARS-CoV outbreak in 2002 to the current SARS-CoV-2 variant Omicron, and potentially dangerous variants that may emerge in the future.
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When artificial neural networks spend time not learning, they learn better
Time of Update: 2023-01-05
”Senior author Bazhenov and colleagues discuss in the November 18, 2022 issue of PLOS Computational Biology how biological models can help mitigate the threat of catastrophic forgetting in artificial neural networks, increasing their utility across a range of research areas of interest.
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Studies of protein molecular movement reveal previously unseen binding sites
Time of Update: 2023-01-05
"essayIncreased slow dynamics defines ligandability of BTB domains A research team led by Kaust revealed the properties of the MIZ1 protein (pictured above).
"essayIncreased slow dynamics defines ligandability of BTB domains A research team led by Kaust revealed the properties of the MIZ1 protein (pictured above).
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Crohn's disease (CD) new drug! EU approves Skyrizi: first specific IL-23 inhibitor for the treatment of CD!
Time of Update: 2023-01-05
Nov. 22, 2022 /Biovalley BIOON/ -- AbbVie has announced that the European Commission (EC) has approved a new indication for the new anti-inflammatory drug IL-23 inhibitor Skyrizi (risankizumab, 150mg): Skyrizi 600mg intravenous (IV) induction and 360mg subcutaneous (SC) maintenance regimen for the treatment of inadequate response to conventional or biological therapy, Adults with moderately to severely active Crohn's disease (CD) who are unresponsive or intolerant.
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Nature has newly reported that genetic variants may disrupt the production of myelin
Time of Update: 2023-01-05
The study further found that in mice carrying APOE4, clearing blocked cholesterol — the main component of myelin — and allowing the substance to cross cell membranes partially restored myelin production and improved cognitive performance, suggesting that this is a therapeutic target against Alzheimer's disease.
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Qinghai Key Laboratory of Cold Region Restoration Ecology uses a three-dimensional ecological footprint model to reveal the dynamic changes of natural capital and its driving factors in Qinghai Province
Time of Update: 2023-01-05
Paper link Fig. 1 Composition of per capita ecological footprint accounts in Qinghai Province from 2011 to 2020 Fig. 2 Historical changes of natural capital flow occupancy rate by different land use types in Qinghai Province Natural capital is the basic condition for human survival, and the evaluation of the utilization of natural capital is the core issue of regional sustainable development.
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Chinese scholars have made progress in the research of cryogenic brain protection
Time of Update: 2023-01-05
Figure Deep brain stimulation induced hypothermia has a neuroprotective effect on ischemic stroke With the funding of the National Natural Science Foundation of China (approval number: 81871026) and
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A diagnostic biomarker that can identify fatal brain diseases with high accuracy
Time of Update: 2023-01-05
and Joanne Knight Distinguished Professor of Neurology — used the technique to look for a unique form of tau protein associated with primary psoriasis 。 To ensure accurate classification of the study subjects, Horie Sato and Bateman collaborated with co-authors Adam Boxer, M.
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How liver cells in liver cancer go astray
Time of Update: 2023-01-05
Mossmann said: "We wanted to know why all acetyl-CoA metabolic pathways are inhibited in tumor cells.
Mossmann said: "We wanted to know why all acetyl-CoA metabolic pathways are inhibited in tumor cells.
Mossmann said: "We wanted to know why all acetyl-CoA metabolic pathways are inhibited in tumor cells.
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Artificial sweeteners can kill antibiotic-resistant bacteria and have the potential to replace antibiotics in some cases
Time of Update: 2023-01-05
Three artificial sweeteners used in products such as diet drinks, yogurt and desserts significantly prevented the growth of priority multidrug-resistant pathogens.
Three artificial sweeteners used in products such as diet drinks, yogurt and desserts significantly prevented the growth of priority multidrug-resistant pathogens.
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Tang Chun and his collaborators used structure prediction and cross-linked mass spectrometry to build the "missing" structure in cryo-EM
Time of Update: 2023-01-05
cnResearch field: Professor Tang Chun's research group is committed to the development of integrated calculation methods for biological macromolecular structures based on experimental data, including biomagnetic resonance methods and biophysical and chemical methods, to better characterize the dynamic ensemble of biological macromolecular structures in equilibrium or non-equilibrium states, analyze the regulation of macromolecular structures by complex cellular environments and chemical modifications, and the relationship between dynamic structural imbalance and disease occurrence.
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A new standard for first-line treatment of prostate cancer (mCRPC)! PARP inhibitor + new hormone therapy combination regimen Lynparza + Zyetiga is about to be approved in Europe and the United States!
Time of Update: 2023-01-05
Nov. 16, 2022 /Biovalley BIOON/ -- AstraZeneca and Merck & Co have announced that the European Medicines Agency (EMA) Committee on Medicinal Products for Human Use (CHMP) has issued a positive review recommending the approval of the PARP inhibitor-like anticancer drug Lynparza (Chinese brand name: Lipzo, generic name: olaparib, Olaparib): a combination of abiraterone and prednisone or prednisolone for the treatment of adult patients with metastatic castration-resistant prostate cancer (mCRPC) who are not clinically amenable to chemotherapy.
