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Nature: Folate transporters provide clues to anticancer drugs or drive the success of cancer immunotherapy
Time of Update: 2023-01-05
SLC19A1 transport CDN(a) and folate/folic acid (b) conceptual map and model mapIn summary, this study reports the molecular basis of human SLC19A1 for recognizing different substrates such as CDN, folic acid and folic acid resistance, reveals its unique and diverse substrate recognition mechanism, and identifies a novel substrate recognition mode of SLC and MFS families.
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The accumulation of inhaled particulate matter can impair the immune function and structure of the lymph nodes in the human lungs
Time of Update: 2023-01-05
summaryOlder adults are particularly susceptible to pulmonary infectious and neoplastic diseases, and it is unclear how lifelong exposure to environmental pollutants affects respiratory immune function.
Older adults are particularly susceptible to pulmonary infectious and neoplastic diseases, and it is unclear how lifelong exposure to environmental pollutants affects respiratory immune function.
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Miao Peng's research group of Suzhou Medical Institute has made progress in the assembly of linear hybridization chain reactions
Time of Update: 2023-01-05
DSNsDSNsDNA/RNA heterozygous duplexes 。 The DNA in this heterozygous double-stranded is specifically digested and released miRNA for cycling reactions, while yielding two single-stranded probes B and C DNA triangular prism nanostructures that further act on the electrode interface.
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EMBO J: Zhiyuan Zhang/Zhiren Zhang's team discovered the importance of a new mechanism of systematic Aβ clearance for Alzheimer's disease
Time of Update: 2023-01-05
Professor Zhang Zhiyuan's research group from the School of Basic Medical Sciences of Nanjing Medical University and Professor Zhang Zhiren's research group from the All-Army Institute of Immunology of Army Medical University published a research paper in EMBO Journal entitled "Erythropoietin signaling in peripheral macrophages is required for systemic β-amyloid clearance.
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Progress has been made in the study of the evolution law and driving mechanism of the active bank of black soil organic matter in Nanjing
Time of Update: 2023-01-05
Paper link Conceptual diagram of oxygen-induced dynamics of dissolved organic masses and their main mechanisms Dissolved organic matter is the most active functional component of soil organic matter, which affects the formation of soil stable carbon pool, biogeochemical processes, and soil response and feedback to climate change.
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Shaojun Guo's team from the School of Materials Science and Engineering published a review in Nature Reviews Chemistry: Optimizing Semiconductor-Metal Monogen...
Time of Update: 2023-01-05
2020, 10, 9109）。Based on the previous research, the team was recently invited by Nature Reviews Chemistry to conduct an in-depth discussion and summary of the interaction between semiconductors and metal monatoms in metal monoatomic photocatalysts at the atomic and electron scales (as shown in the figure below).
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Cancer Cell: Mapping the molecules of ductal carcinoma in situ (DCIS).
Time of Update: 2023-01-05
Most DCIS cancers analyzed in the study were determined to be at low risk of cancer progression or recurrence, a factor that underscores the need for an accurate predictive model that can be used to guide treatment at clinical visits, Hwang said.
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The genetic background has an impact on the metabolism of essential fatty acids in the human body
Time of Update: 2023-01-05
Supplementing the diet with camelina oil rich in -linolenic acid or sunflower oil rich in linoleic acid changes the concentration of metabolites of these fatty acids in the body; However, these changes depend on the FADS1 genotype of the study participants.
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New evidence points to a link between mitochondria and cancer
Time of Update: 2023-01-05
If widely developed, tested, and validated, this (Mic60-low gene signature) could become a potentially simple point-of-service molecular tool for pancreatic cancer prognosis or patient risk stratification and treatment response prediction.
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MIT scientists reveal the functional pattern of basic genes
Time of Update: 2023-01-05
” Using a novel, ensemble, image-based screening method, a team of scientists at the Whitehead Institute for Biomedical Research, the Massachusetts Institute of Technology, and Harvard University's Broad Institute systematically assessed the function of more than 5,000 basic human genes.
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Genomic Medicine: Understanding the aggressiveness of lung squamous cell carcinoma through the tumor stroma
Time of Update: 2023-01-05
1186/s13073-022-01127-6 Scientists at the Gavin Institute of Medical Research in Australia have identified a molecular profile of the surrounding stroma of a common subtype of lung cancer, which promises to indicate which patients are likely to progress to aggressive tumors.
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Nature has newly reported that genetic variants may disrupt the production of myelin
Time of Update: 2023-01-05
The study further found that in mice carrying APOE4, clearing blocked cholesterol — the main component of myelin — and allowing the substance to cross cell membranes partially restored myelin production and improved cognitive performance, suggesting that this is a therapeutic target against Alzheimer's disease.
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How liver cells in liver cancer go astray
Time of Update: 2023-01-05
Mossmann said: "We wanted to know why all acetyl-CoA metabolic pathways are inhibited in tumor cells.
Mossmann said: "We wanted to know why all acetyl-CoA metabolic pathways are inhibited in tumor cells.
Mossmann said: "We wanted to know why all acetyl-CoA metabolic pathways are inhibited in tumor cells.
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Chinese scholars have made progress in the research of silver-copper nanoclusters
Time of Update: 2023-01-05
Figure Magnetic changes in the assembly and unassembly of ag77Cu22 clusters With the support of the National Natural Science Foundation of China (approval numbers: 21925303, 21771186, 91961204, 22171
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Hong Kong University of Science and Technology: A new method that can increase the efficiency of protein production for synthesizing mRNA by a factor of 10
Time of Update: 2023-01-05
Source: The Hong Kong University of Science and TechnologyA team of synthetic biologists at the Hong Kong University of Science and Technology (HKUST) recently discovered a way to increase the efficiency of protein production of synthetic mRNA by a factor of 10, meaning that mRNA vaccines and drugs used to treat cancer, Covid-19 or other genetic diseases can be greatly improved with fewer mRNA doses.
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Crohn's disease (CD) new drug! EU approves Skyrizi: first specific IL-23 inhibitor for the treatment of CD!
Time of Update: 2023-01-05
Nov. 22, 2022 /Biovalley BIOON/ -- AbbVie has announced that the European Commission (EC) has approved a new indication for the new anti-inflammatory drug IL-23 inhibitor Skyrizi (risankizumab, 150mg): Skyrizi 600mg intravenous (IV) induction and 360mg subcutaneous (SC) maintenance regimen for the treatment of inadequate response to conventional or biological therapy, Adults with moderately to severely active Crohn's disease (CD) who are unresponsive or intolerant.
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Chinese scholars have made progress in the research of cryogenic brain protection
Time of Update: 2023-01-05
Figure Deep brain stimulation induced hypothermia has a neuroprotective effect on ischemic stroke With the funding of the National Natural Science Foundation of China (approval number: 81871026) and
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The discovery could lead to new drugs that block proteins that cause bowel cancer
Time of Update: 2023-01-05
The researchers believe that "domains" — specific regions in proteins associated with different functions — that allow tankyrases to assemble and break down into different structures are exciting targets for future cancer drugs.
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Studies of protein molecular movement reveal previously unseen binding sites
Time of Update: 2023-01-05
"essayIncreased slow dynamics defines ligandability of BTB domains A research team led by Kaust revealed the properties of the MIZ1 protein (pictured above).
"essayIncreased slow dynamics defines ligandability of BTB domains A research team led by Kaust revealed the properties of the MIZ1 protein (pictured above).
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Tang Chun and his collaborators used structure prediction and cross-linked mass spectrometry to build the "missing" structure in cryo-EM
Time of Update: 2023-01-05
cnResearch field: Professor Tang Chun's research group is committed to the development of integrated calculation methods for biological macromolecular structures based on experimental data, including biomagnetic resonance methods and biophysical and chemical methods, to better characterize the dynamic ensemble of biological macromolecular structures in equilibrium or non-equilibrium states, analyze the regulation of macromolecular structures by complex cellular environments and chemical modifications, and the relationship between dynamic structural imbalance and disease occurrence.
