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Blocks nerve loss in neurodegenerative diseases
Time of Update: 2022-10-31
Two new studies from the Washington University School of Medicine in St. Louis support the development of a broadly applicable treatment for neurodegenerative diseases that targets a molecule that acts as a central executioner during the death of axons in the nervous system's circuits.
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Bioengineering is used to frame physiological blood vessels
Time of Update: 2022-10-31
"Microfluidic Bioprinting of Tough Hydrogel-based Vascular Conduits for Functional Blood Vessels Bioengineered blood vessels demonstrate the physiological properties of real blood vessels, including strong vasoconstriction, vasodilation, vascular perfusion, etc.
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Changing the textbook model: a new signaling process for GPCRs
Time of Update: 2022-10-31
Image credit: UC San Diego School of Health SciencesResearchers at the University of California, San Diego, have discovered a new signaling process involving G protein-coupled receptors (GPCRs), a cellular target that has been utilized by hundreds of different drugs.
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The latest paper from Sichuan University: For the first time, the central mechanism of the new factor MANF through POMC neurons regulating the energy balance of the system is revealed
Time of Update: 2022-10-31
In November 2022, the team of Professor He Jinhan of the Institute of Metabolic Diseases and Therapeutics of our hospital published a research paper entitled "MANF in POMC neurons promotes brown adipose tissue thermogenesis and protects against diet-induced obesity" in the well-known international journal in the field of diabetes.
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The Nanjing Soil Institute has made progress in the preparation of remediation materials based on nonlinear optical materials for efficient mercury removal
Time of Update: 2022-10-31
Mercury is a non-degradable toxic heavy metal derived mainly from natural and man-made pollution. It occurs in a variety of forms, with methylmercury being the most toxic, with its bioconcentration a
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The 2022 annual exchange meeting of the Strategic Leading Science and Technology Special Project (Category B) of the Chinese Academy of Sciences "Pathogen Host Adaptation and Immune Intervention" was held
Time of Update: 2022-10-31
On October 20, the 2022 annual exchange meeting of the Strategic Leading Science and Technology Special (Class B) of the Chinese Academy of Sciences "Pathogen Host Adaptation and Immune Intervention"
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Innovative treatment for paroxysmal nocturnal hemoglobinuria (PNH)! Novartis' first complement factor B inhibitor iptacopan: phase 3 clinical efficacy is better than anti-C5 therapy!
Time of Update: 2022-10-31
APPLY-PNH is a Phase 3, randomized, multinational, multicenter, active-controlled, open-label trial of adult PNH patients with residual anemia despite receiving a stable anti-C5 regimen in the last 6 months prior to randomization, designed to demonstrate the superiority of iptacopan monotherapy (200 mg orally twice daily) over anti-C5 therapy Soliris or Ultomiris.
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Yu Yongfu and Qin Guoyou's research group of Fudan University have made progress in the field of hypertensive diseases in pregnancy
Time of Update: 2022-10-31
Hypertensive disorders during pregnancy pose a serious threat to maternal and fetal health and safety and are a common complication during pregnancy, affecting about 10% of pregnant women. Recently,
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The new method thoroughly reveals the strong impact of genome copy number changes on human health
Time of Update: 2022-10-31
"Being able to delve into the potential of these variants gives us more opportunities to discover the ways in which genetic variants affect human phenotypes," said Po-Ru Loh, an associate member of Broad, senior author of the study and an assistant professor at Brigham and Women's Hospital and Harvard Medical School.
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New target of anti-progeria: scientists successfully reversed the "progeria"
Time of Update: 2022-10-31
"Based on theoretical considerations, we hypothesize that molecular interactions between L1 RNA and a specific enzyme that controls heterochromatin stability may be responsible for premature aging of Progeria syndrome," said Francesco Della Valle, a research scientist at King Abdullah University of Science and Technology (KAUST).
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Chinese scholars have made progress in the activation of inert C-H bonds
Time of Update: 2022-10-31
Fig. Room temperature visible light based on "single atom Pt assembly" catalytic material drives the reaction of cyclohexane with methane oxygen-free dehydrogenation With the support of the National
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Science Advances: How physical exercise burns muscle fat
Time of Update: 2022-10-31
Image: Confocal microscopy image shows the presence of IL6 protein in ventromedial hypothalamic neurons (red) in resting mice on the left and post-exercise mice on the right An article describes for the first time a neuromuscular circuit that links the burning of muscle fat to the activity of a protein in the brain.
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iScience: Genes involved in neuronal structure and function can protect against Alzheimer's disease
Time of Update: 2022-10-31
AULORA, Colorado (Oct. 25, 2022) — Overexpression of a gene associated with cell division and neuronal structure and function may prevent and protect cognitive decline in mice and humans with Alzheimer's disease (AD), according to a new study by scientists at the University of Colorado's Anschutz School of Medicine.
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Nature Answers the Mystery: Evidence for a New Theory of Genetic Recombination
Time of Update: 2022-10-31
Joint strategies have led to a massive increase in genetic recombination. Compared to normal cells (left), the crossover portion marked with a green dot on the purple chromosome is massively increase
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Nature: E-cigarettes can cause arrhythmias
Time of Update: 2022-10-31
The findings, published Oct. 25 in the journal Nature Communications, show that exposure to specific chemicals in e-cigarette liquids can cause arrhythmias and interfere with the heart conduction system.
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Chengdu Institute of Biology has made new progress in the response and mechanism of soil nutrient stoichiometry to changes in gravel content in arid valleys
Time of Update: 2022-10-31
szechuanensis) and Sophora davidii and blank control were used as vegetation treatments, and 0-10 cm, 10-20 were determined and analyzed under different treatments cm, 20-30 cm and 30-40 cm soil layers C, N, P The variation trend of its measurement ratio explores the differences in nutrient status under different native species, and reveals the effects and mechanisms of gravel content and vegetation treatment on nutrient stoichiometry.
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Nature Communications: Revealing a new mechanism by which the brain processes parallel circuits in the nucleus accumbens for reward and disgust
Time of Update: 2022-10-31
NAcBLA neurons and NAcPVT neurons project to different downstream brain regions, respectively The motivation of animal behavior can be simply summarized as "seeking advantage and avoiding harm".
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The State Key Laboratory of Virology/National Virus Resource Bank of Wuhan Institute of Virology has made new progress in the study of antiviral effect and mechanism of the antifungal drug anifungin
Time of Update: 2022-10-31
1186/s12916-022-02558-z Fig. Figure: Pattern of action of anitifungin inhibition of viral infection invasion In October 2022, the international academic journal BMC Medicine published the latest results of the State Key Laboratory of Virology/National Virus Resource Library of the State Key Laboratory of Virology/National Virus Resource Library of the Chinese Academy of Sciences online with the paper "Antiviral activity and mechanism of the antifungal drug, anidulafungin, suggesting its potential.
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The Teng Yuanwen/Bai Songling team of Zhejiang University made progress in the study of the regulatory mechanism of light-induced pear peel anthocyanin synthesis
Time of Update: 2022-10-31
Fig. 1 Transient overexpression of 'nightshade' callus transgene and leaves of autumn pear showed that PpWRKY44 induced anthocyanin synthesisFig. 2 Light-induced PpWRKY44 model for inducing anthocyanin synthesis of pear peel by regulating PpMYB10Ahmed Alabd, a doctoral student at the College of Agriculture and Biotechnology, Zhejiang University, is the first author of the paper, and Professor Teng Yuanwen and researcher Bai Songling are the co-corresponding authors of the paper.
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The latest study by the Nobel Prize winner team: "Drinking water is fat" turns out to be a defect in this gene
Time of Update: 2022-10-31
Dr. Zhao ZhangThe findings, published in the journal Cell Metabolism, describe how a genetic defect called Ovol2 causes mice with normal activity levels and food intake to become obese in adulthood due to problems with body heat.
