Yu Yongfu and Qin Guoyou's research group of Fudan University have made progress in the field of hypertensive diseases in pregnancy

Hypertensive disorders during pregnancy pose a serious threat to maternal and fetal health and safety and are a common complication during pregnancy, affecting about 10% of pregnant women
.
Recently, Yu Yongfu and Qin Guoyou's research group at the School of Public Health of Fudan University and Professor Jiong Li of Aarhus University in Denmark have collaborated to study progress in
gestational hypertension and offspring health 。 The research paper "Maternal hypertensive disorder of pregnancy and mortality in offspring from birth to young adulthood: national population based cohort study" was published in the British Medical Journal (BMJ)
in October 2022.

Previous studies of the research group have suggested the effects of gestational diabetes and hypertensive diseases on cardiovascular health and mental health in mothers, and the relevant research results have been published in BMJ (2019), Diabetes Care (2022), PLoS Medicine (2021), JAMA Network Open (2021 & 2022), European Journal of Epidemiology (2021) and other journals
。

To explore the relationship between maternal hypertensive disorders during pregnancy and all-cause and cause-specific mortality in offspring from birth to early adulthood, Yu Yongfu and Qin Guoyou's team conducted a cohort study
based on a large sample population.
The study found a 26 percent
increased risk of all-cause death in offspring born to mothers with hypertensive disorders during pregnancy.
The risks associated with preeclampsia, eclampsia and gestational hypertension are increased by 29%, 188%, and 12%,
respectively.
The study also found an increased risk of death from specific causes in offspring, including more than doubling the risk of death due to digestive and perinatal diseases, and more than
50% of the risk of death due to endocrine, nutritional, metabolic and cardiovascular diseases.
This study demonstrates that maternal hypertensive disorders of pregnancy, particularly eclampsia and severe preeclampsia, are associated
with an increased risk of all-cause death and death from all specific causes in offspring from birth through early adulthood.

Huang Chen and Wei Ke, doctoral students of the Department of Biostatistics, School of Public Health, Fudan University, became the co-first authors of this paper, Professor Yu Yongfu, Professor Qin Guoyou, Young Research Fellow and Professor Qin Guoyou of the School of Public Health, Fudan University, and Professor Jiong Li of Aarhus University, Denmark, as co-corresponding authors, and Dr.
Priscilla Ming Yi Lee of Aarhus University, Denmark, as co-authors
of the paper 。 The research was supported
by the National Natural Science Foundation of China (82173612), the Shanghai Youth Science and Technology Star Program (21QA1401300), the Shanghai Natural Science Foundation (22ZR1414900) and the Shanghai Municipal Science and Technology Major Project (ZD2021CY001).

Links to papers: