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In October 2022, the international academic journal BMC Medicine published the latest results of the State Key Laboratory of Virology/National Virus Resource Library of the State Key Laboratory of Virology/National Virus Resource Library of the Chinese Academy of Sciences online with the paper "Antiviral activity and mechanism of the antifungal drug, anidulafungin, suggesting its potential.
" to promote treatment of viral diseases”
。 The study found that the antifungal drug anifungin has antiviral effects and explored its mechanism of action
.
" to promote treatment of viral diseases”
。 The study found that the antifungal drug anifungin has antiviral effects and explored its mechanism of action
.
Severe fever with thrombocytopenia syndrome disease (SFTS) is a severe febrile illness
caused by infection with the tick-borne virus - fever with thrombocytopenia syndrome virus (SFTSV).
Due to its high case fatality rate and lack of effective antiviral drugs and vaccines, it has been listed by the World Health Organization as one of the top ten infectious diseases of
urgent concern.
The development of effective SFTS treatment drugs is important
to optimize disease treatment strategies and improve treatment rates.
caused by infection with the tick-borne virus - fever with thrombocytopenia syndrome virus (SFTSV).
Due to its high case fatality rate and lack of effective antiviral drugs and vaccines, it has been listed by the World Health Organization as one of the top ten infectious diseases of
urgent concern.
The development of effective SFTS treatment drugs is important
to optimize disease treatment strategies and improve treatment rates.
The research team used the SFTSV infection cell model to screen 1340 drugs in the FDA drug library and obtained 6 drugs
that had inhibitory effects on SFTSV infection.
Unlike the other 5 drugs, which have inhibitory effect on the post-cell stage of virus infection, the echinocene antifungal drug anifungin has a significant inhibitory effect on the SFTSV invasion stage, and the incubation of high-concentration anifungin with the virus can affect the morphology of virus particles and then inhibit viral infection
。 Anistungin was combined with inhibitors of different stages of the clathrin-mediated endocytic pathway for viral infection invasion to detect SFTSV RNA copies in infected cells, analyze the time phase of viral protein expression and quantitatively detect viral infection efficiency, and found that anifungin inhibits viral endocytosis by affecting late endocytic maturation, and can also inhibit viral glycoprotein-mediated membrane fusion, thereby reducing the efficiency
of viral infection 。 The study also found that anitifunin has a good therapeutic effect on A129 mice infected with type I interferon receptor deficiency, which can effectively relieve mouse symptoms, improve mouse survival rate, and reduce mouse tissue damage
caused by SFTSV infection.
In addition, with a delay of 1, 2 and 3 days of drug treatment in infected mice, anifinegin still had a good therapeutic effect
.
Anityfungin also inhibits the invasion of host cells by SARS-CoV-2, SFTSV-associated Gultu virus (GTV) and hinterland virus (HRTV), Crimean-Congo hemorrhagic fever virus (CCHFV), Zika virus (ZIKV) and herpes simplex virus 1 (HSV-1) infection, and has a broad-spectrum antiviral effect
.
The results showed that anifungin is not only an antifungal drug that can inhibit fungal cell wall synthesis, but also an antiviral drug
.
The study also explored the versatility of antifungal drugs such as amphotericin B, itraconazole, anifungin, etc.
, suggesting the clinical importance of such drugs in the treatment of viral infectious diseases with fungal infections, and of great significance
for optimizing disease treatment regimens and improving the treatment effect and prognosis of patients with viral and fungal infections.
that had inhibitory effects on SFTSV infection.
Unlike the other 5 drugs, which have inhibitory effect on the post-cell stage of virus infection, the echinocene antifungal drug anifungin has a significant inhibitory effect on the SFTSV invasion stage, and the incubation of high-concentration anifungin with the virus can affect the morphology of virus particles and then inhibit viral infection
。 Anistungin was combined with inhibitors of different stages of the clathrin-mediated endocytic pathway for viral infection invasion to detect SFTSV RNA copies in infected cells, analyze the time phase of viral protein expression and quantitatively detect viral infection efficiency, and found that anifungin inhibits viral endocytosis by affecting late endocytic maturation, and can also inhibit viral glycoprotein-mediated membrane fusion, thereby reducing the efficiency
of viral infection 。 The study also found that anitifunin has a good therapeutic effect on A129 mice infected with type I interferon receptor deficiency, which can effectively relieve mouse symptoms, improve mouse survival rate, and reduce mouse tissue damage
caused by SFTSV infection.
In addition, with a delay of 1, 2 and 3 days of drug treatment in infected mice, anifinegin still had a good therapeutic effect
.
Anityfungin also inhibits the invasion of host cells by SARS-CoV-2, SFTSV-associated Gultu virus (GTV) and hinterland virus (HRTV), Crimean-Congo hemorrhagic fever virus (CCHFV), Zika virus (ZIKV) and herpes simplex virus 1 (HSV-1) infection, and has a broad-spectrum antiviral effect
.
The results showed that anifungin is not only an antifungal drug that can inhibit fungal cell wall synthesis, but also an antiviral drug
.
The study also explored the versatility of antifungal drugs such as amphotericin B, itraconazole, anifungin, etc.
, suggesting the clinical importance of such drugs in the treatment of viral infectious diseases with fungal infections, and of great significance
for optimizing disease treatment regimens and improving the treatment effect and prognosis of patients with viral and fungal infections.
Researcher Deng Fei of the State Key Laboratory of Virology/National Virus Resource Bank of Wuhan Institute of Virology is the corresponding author of the paper, and Shen Shu, a young researcher from Wuhan Institute of Virology/National Virus Resource Bank, is the first author of the paper, and the research has been supported by the National Natural Science Foundation of China (U20A20135), the National Key Research and Development Program of China (2018YFE0200400 and 2019YFC1200701), Supported by
the Biological Resources Program of the Chinese Academy of Sciences (KFJ-BRP-017-06 and KFJ-BRP-017-74).
the Biological Resources Program of the Chinese Academy of Sciences (KFJ-BRP-017-06 and KFJ-BRP-017-74).
Article link: https://doi.
org/10.
1186/s12916-022-02558-z
org/10.
1186/s12916-022-02558-z
Fig.
Figure: Pattern of action of anitifungin inhibition of viral infection invasion
Figure: Pattern of action of anitifungin inhibition of viral infection invasion