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Effects of noncoding genomic changes on neurodevelopment
Time of Update: 2022-10-31
Less than 2 percent of the human genome is made up of genes that code for proteins, and the remaining 98 percent are non-coding genes that are involved in regulating gene expression. Scientists have
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Can gut bacteria cause rheumatoid arthritis?
Time of Update: 2022-10-31
”A new target for rheumatoid arthritisIf this unique bacterium does drive the immune response in individuals at risk of causing rheumatoid arthritis, Kuhn said, it may be possible to target the bacteria with drugs to stop that reaction from happening.
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A small peptide boosts almonds' defenses against damaging bacteria
Time of Update: 2022-10-31
At the University of Girona in Spain, collaborators Luís Moll and Aina Baró-plus from the Montesinos Laboratory demonstrated that small peptides (molecules containing up to 50 amino acid chains) are a promising treatment that can prevent cases caused by x fastidiosa, such as almond leaf burnt disease (ALS).
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Chinese scholars have made progress in the carboxylation of non-activated olefins
Time of Update: 2022-10-31
Figure Carboxylation ofCO2 with non-activated olefins based on continuous photoelectron transfer strategy With the support of the National Natural Science Foundation of China (grant number: 22225106, 21822108), Yu Dagang's team at Sichuan University developed a new method for the carboxylation of non-activated olefins catalyzed by visible light.
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New drugs have been found to be effective in treating complex urinary tract infections
Time of Update: 2022-10-31
"Effect of Cefepime/Enmetazobactam vs Piperacillin/Tazobactam on Clinical Cure and Microbiological Eradication in Patients With Complicated Urinary Tract Infection or Acute Pyelonephritis A Randomized Clinical Trial JAMA An international study led by a Rutgers scientist compared old and new treatments for complex urinary tract infections and found a new combination of drugs that were more effective, especially against stubborn drug-resistant infections.
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A new protein is discovered in yeast
Time of Update: 2022-10-31
"We found that some of the ancient TORC1 regulators found in humans, including Rheb, were lost in yeast that obtained ait12 200 million years ago," Capaldi said.
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Nature: New methods for tagging proteins help track disease
Time of Update: 2022-10-31
In their study, published today (Oct. 25) in the journal Nature Communications, the team developed a new method that can identify proteins released by specific types of cells, even if those cells live in a complex environment with many other types of cells.
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New ways to measure brain activity could help people with multiple sclerosis
Time of Update: 2022-10-31
" Image: Spatial and temporal structure, showing connections between edges Researchers at the Human Brain Project have developed a new method to calculate the delay in signal propagation in the brains of multiple sclerosis patients.
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Huang Zhili's research group discovered the new nucleus and loop mechanism of stopping REM sleep
Time of Update: 2022-10-31
Researchers Chen Zeka, Dong Hui and Liu Chengwei found that specific activation of dDpMe GABAergic neurons can quickly terminate REM sleep and promote the conversion of REM to NREM sleep through fiber calcium signal recording, in vivo and ex vivo electrophysiological recording, optogenetics, chemogenetics and RNA interference.
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Hubei Province Local Standard "Technical Regulations for Efficient Fertilization of Cotton" publicity and evaluation of production and application effects...
Time of Update: 2022-10-31
Reviewer: Yang Guozheng Nanhu News Network News (correspondent Yan Zhenhua) In order to promote the standardization of cotton production in Hubei Province, achieve agricultural efficiency, increase farmers' income, and help rural revitalization, on the morning of October 23, the promotion of local standards "Technical Regulations for Efficient Fertilization of Cotton" and the evaluation of production and application effects of Hubei Province were held in the Modern Agricultural Science and Technology Demonstration Park of Huanggang Academy of Agricultural Sciences.
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Zhang Haitao's research group at the School of Pharmacy of Zhejiang University reported in Nature Communications that the drug target histamine H3...
Time of Update: 2022-10-31
In this study, the crystal structure of the complex of human histamine receptor H3R and antagonist PF-03654746 was analyzed by protein crystallography, and the antagonist PF-03654746 was systematically elucidated by combining computational and functional experimental results The unique binding mode of allosteric regulation of molecular cholesterol and the conserved binding mode of different antagonists provide a structural basis for the design of H3R-based drugs.
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The team of Huang Bin of the Third Affiliated Hospital has made new progress in the study of the mechanism of osteoporosis
Time of Update: 2022-10-31
Diagram of the mode of action of skin keratinocytes secreting cystatin-A (Csta) in regulating bone metabolismOsteoporosis is a common degenerative disease of the bone, which is mainly manifested by osteopenia, destruction of bone microstructure, and increased bone fragility.
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PNAS: Which sources contribute to differences in air pollution
Time of Update: 2022-10-31
5 exposure inequality While air quality has improved significantly over the past 50 years thanks in part to the Clean Air Act, people of color in the United States of all income levels are still exposed to above-average air pollution.
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The Nanjing Soil Institute has made progress in the preparation of remediation materials based on nonlinear optical materials for efficient mercury removal
Time of Update: 2022-10-31
Mercury is a non-degradable toxic heavy metal derived mainly from natural and man-made pollution. It occurs in a variety of forms, with methylmercury being the most toxic, with its bioconcentration a
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Chinese scholars have made progress in the activation of inert C-H bonds
Time of Update: 2022-10-31
Fig. Room temperature visible light based on "single atom Pt assembly" catalytic material drives the reaction of cyclohexane with methane oxygen-free dehydrogenation With the support of the National
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The latest paper from Sichuan University: For the first time, the central mechanism of the new factor MANF through POMC neurons regulating the energy balance of the system is revealed
Time of Update: 2022-10-31
In November 2022, the team of Professor He Jinhan of the Institute of Metabolic Diseases and Therapeutics of our hospital published a research paper entitled "MANF in POMC neurons promotes brown adipose tissue thermogenesis and protects against diet-induced obesity" in the well-known international journal in the field of diabetes.
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The 2022 annual exchange meeting of the Strategic Leading Science and Technology Special Project (Category B) of the Chinese Academy of Sciences "Pathogen Host Adaptation and Immune Intervention" was held
Time of Update: 2022-10-31
On October 20, the 2022 annual exchange meeting of the Strategic Leading Science and Technology Special (Class B) of the Chinese Academy of Sciences "Pathogen Host Adaptation and Immune Intervention"
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New target of anti-progeria: scientists successfully reversed the "progeria"
Time of Update: 2022-10-31
"Based on theoretical considerations, we hypothesize that molecular interactions between L1 RNA and a specific enzyme that controls heterochromatin stability may be responsible for premature aging of Progeria syndrome," said Francesco Della Valle, a research scientist at King Abdullah University of Science and Technology (KAUST).
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The new method thoroughly reveals the strong impact of genome copy number changes on human health
Time of Update: 2022-10-31
"Being able to delve into the potential of these variants gives us more opportunities to discover the ways in which genetic variants affect human phenotypes," said Po-Ru Loh, an associate member of Broad, senior author of the study and an assistant professor at Brigham and Women's Hospital and Harvard Medical School.
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Yu Yongfu and Qin Guoyou's research group of Fudan University have made progress in the field of hypertensive diseases in pregnancy
Time of Update: 2022-10-31
Hypertensive disorders during pregnancy pose a serious threat to maternal and fetal health and safety and are a common complication during pregnancy, affecting about 10% of pregnant women. Recently,
