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Protein degradation targets the chimera database PROTAC-DB 2.0
Time of Update: 2022-11-15
1093/nar/gkac946/6775390 Proteolytic targeting chimera (PROTAC) is an emerging drug therapy that mediates the interaction between the target protein and E3 ubiquitin ligase and passes through ubiquitin - The proteasome system achieves specific degradation of the target protein.
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The University of Science and Technology of China/Shenzhen Advanced Institute of the Chinese Academy of Sciences has made an important breakthrough in the development of cryo-EM in situ imaging technology
Time of Update: 2022-11-15
The team of Bi Guoqiang, a dual-appointed professor from the University of Science and Technology of China and the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, cooper
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The visual meaning of "looking down" when fish swim
Time of Update: 2022-11-15
”Optic Flow in the Natural Habitats of Zebrafish Supports Spatial Biases in Visual Self-Motion Estimation Video: Watch the zebrafish swim along a moving pattern, projected on the bottom of its tank.
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"Unexpected"! Scientists have discovered a new anti-aging mechanism that does not rely on telomerase
Time of Update: 2022-11-15
”Our findings shed light on a different mechanism that does not require telomerase to lengthen telomeres and works when telomerase is still inactive in cellsReferences: "An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory" by Alessio Lanna, Bruno Vaz, Clara D'Ambra, Salvatore Valvo, Claudia Vuotto, Valerio Chiurchiù, Oliver Devine, Massimo Sanchez, Giovanna Borsellino, Arne N.
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Chinese scholars have made progress in osteoarthritis research
Time of Update: 2022-11-15
Figure The process and mechanism of top-down and bottom-up bidirectional cartilage calcification in the progression of human knee OA With the support of the National Natural Science Foundation of China (grant number: T2121004, 31830029, 82002271, 81902187), Professor Ouyang Hongwei's research group of Zhejiang University revealed for the first time the pathological mechanism of top-down and bottom-up bidirectional calcified articular cartilage layer in the development of osteoarthritis (OA) from the multidisciplinary perspectives of material molecular assembly, microstructure and micromechanics.
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Chinese scholars have made new progress in the field of genetic adaptation of birds on the Qinghai-Tibet Plateau
Time of Update: 2022-11-15
Figure Falcon colonization of the Qinghai-Tibet Plateau and its genetic adaptation mechanism model With the support of the National Natural Science Foundation of China (grant number: 31930013, 321250
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Inflammation amplifies the effects of genetic risk variants for schizophrenia
Time of Update: 2022-11-15
Researchers at the Karolinska Institutet now report that Nature Communications in first-time patients saw elevated levels of proteins from associated risk genes and inflammation further increasing the expression of risk genesIn the brain in late adolescence, suboptimal connections between nerve cells are eliminated normally.
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Progress has been made in the study of the feedback effect of vegetation change on climate in high Asia
Time of Update: 2022-11-15
TRS_Editor A{margin-top:0px;margin-bottom:15px;line-height:2;font-family:;font-size:12pt;}Remote sensing evidence based on multiple data sources and indicators shows that global warming has greatly enhanced vegetation activities, the vegetation index has shown a significant upward trend, and the growing season has been significantly extended.
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Science: Gene therapy that targets overactive brain cells can treat neurological disorders
Time of Update: 2022-11-15
Article On-demand cell-autonomous gene therapy for brain circuit disordersResearchers at University College London have developed a new treatment for neurological and psychiatric disorders that works by reducing the excitability of overactive brain cells.
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Cell Rep: The role of brain proteins in movement disorders in children
Time of Update: 2022-11-15
" Our findings suggest that the death of Purkinje cells in ARSACS may be due to changes in neuronal connections and synaptic structure," said study co-senior author Justin Wolter, PhD, a postdoctoral researcher at the University of North Carolina Center for Neuroscience.
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Lei Zuhai's research group has made progress in the ratiometrically responsive near-infrared two-region fluorescence molecular imaging platform
Time of Update: 2022-11-15
Probe response mechanism and its application in tumor hypoxic imagingIn this work, a molecular platform Py-2 with emission in the NIR region was designed, which has good universality, based on which two ratiometric molecular fluorescent probes were constructed and the visualization and quantitative monitoring of biomolecules such as enzymes and ROS/RNS in living deep tissues was realized.
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Saiye animal models helped Sun Yat-sen University and other teams discover potential therapeutic targets for KRAS mutated cancers
Time of Update: 2022-11-15
Recently, researchers from the First Affiliated Hospital of Sun Yat-sen University and Nanjing University have found that a protein RASON encoded by a long chain of non-coding RNA between genes (LINC00673) is a key regulator of the oncogenic RAS signaling pathway and is expected to become a therapeutic target for KRAS mutated cancers.
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Cell: Mitochondria initiate a new type of cell death, from pyrotic to necrosis
Time of Update: 2022-11-15
" ”Article Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis As researchers gain a deeper understanding of the dynamic world inside the human immune system, it is becoming increasingly clear that mitochondria are key regulators of our body's response to disease.
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NEJM's largest trial to date has shown that COMP360 psilocybin can reduce depressive symptoms
Time of Update: 2022-11-15
A multicentre clinical trial led by COMPASS Pathways across 22 international locations, including King's College London, South London and the Institute of Psychiatry, Psychology and Neuroscience (IoPPN) of the Maudsley NHS Foundation Trust, found that a single 25mg dose of COMP360 psilocybin, plus psychological support, had a significant effect in reducing depressive symptoms in participants with treatment-resistant depression.
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The mystery of the compression of plant sperm
Time of Update: 2022-11-15
Xiaoqi Feng's team showed how in flowering plants, sperm chromatin (a complex of DNA and proteins) is compacted by a special histone that spontaneously aggregates itself, like oil droplets in water, a phenomenon known as phase separation.
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Developmental Cell: Reveal the molecular mechanism of salt avoidance in plant roots
Time of Update: 2022-11-15
The salinization of soil in China leads to insufficient arable land, which affects the effective supply of food. Exploring the sensing mechanism of plants to salt stress and elucidating the strategie
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Professor Li Guiying's team and Xing Gengmei's team have made new progress in the field of specific thrombolytic therapy for arterial vein thrombosis
Time of Update: 2022-11-15
The team of Professor Li Guiying of the Key Laboratory of Molecular Enzymatic Engineering of the Ministry of Education, College of Life Sciences, Jilin University, and the team of Xing Gengmei, Insti
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Nature: A common dietary fiber that promotes an allergy-like immune response
Time of Update: 2022-11-15
Color-enhanced goblet cells (dark purple) in the lung epitheliumImage credit: Dr Mohammad Arifuzzaman and Dr David ArtisA preclinical study showed that a dietary fiber called inulin, commonly used in
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A new way to activate "hidden" mechanisms in the body to heal diabetic wounds
Time of Update: 2022-11-15
" ” Researchers at Indiana University School of Medicine are looking for a way to heal wounds with a protein that is active in fetuses but largely inactive in adults and is not present in adults with diabetes.
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PLoS ONE: The gut microbiome of carnivores is not the same
Time of Update: 2022-11-15
"Specifically, we found that wild minks in relatively undisturbed environments had more carnivorous diets than mink rats in human-affected areas," said Erin McKenney, assistant professor of applied ecology at North Carolina State University and co-first author of the study.
