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Cell: Mitochondria initiate a new type of cell death, from pyrotic to necrosis
Time of Update: 2022-11-15
" ”Article Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis As researchers gain a deeper understanding of the dynamic world inside the human immune system, it is becoming increasingly clear that mitochondria are key regulators of our body's response to disease.
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Progress has been made in the study of the feedback effect of vegetation change on climate in high Asia
Time of Update: 2022-11-15
TRS_Editor A{margin-top:0px;margin-bottom:15px;line-height:2;font-family:;font-size:12pt;}Remote sensing evidence based on multiple data sources and indicators shows that global warming has greatly enhanced vegetation activities, the vegetation index has shown a significant upward trend, and the growing season has been significantly extended.
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Protein degradation targets the chimera database PROTAC-DB 2.0
Time of Update: 2022-11-15
1093/nar/gkac946/6775390 Proteolytic targeting chimera (PROTAC) is an emerging drug therapy that mediates the interaction between the target protein and E3 ubiquitin ligase and passes through ubiquitin - The proteasome system achieves specific degradation of the target protein.
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Cell Rep: The role of brain proteins in movement disorders in children
Time of Update: 2022-11-15
" Our findings suggest that the death of Purkinje cells in ARSACS may be due to changes in neuronal connections and synaptic structure," said study co-senior author Justin Wolter, PhD, a postdoctoral researcher at the University of North Carolina Center for Neuroscience.
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Professor Li Guiying's team and Xing Gengmei's team have made new progress in the field of specific thrombolytic therapy for arterial vein thrombosis
Time of Update: 2022-11-15
The team of Professor Li Guiying of the Key Laboratory of Molecular Enzymatic Engineering of the Ministry of Education, College of Life Sciences, Jilin University, and the team of Xing Gengmei, Insti
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Saiye animal models helped Sun Yat-sen University and other teams discover potential therapeutic targets for KRAS mutated cancers
Time of Update: 2022-11-15
Recently, researchers from the First Affiliated Hospital of Sun Yat-sen University and Nanjing University have found that a protein RASON encoded by a long chain of non-coding RNA between genes (LINC00673) is a key regulator of the oncogenic RAS signaling pathway and is expected to become a therapeutic target for KRAS mutated cancers.
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Science: Gene therapy that targets overactive brain cells can treat neurological disorders
Time of Update: 2022-11-15
Article On-demand cell-autonomous gene therapy for brain circuit disordersResearchers at University College London have developed a new treatment for neurological and psychiatric disorders that works by reducing the excitability of overactive brain cells.
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PLoS ONE: The gut microbiome of carnivores is not the same
Time of Update: 2022-11-15
"Specifically, we found that wild minks in relatively undisturbed environments had more carnivorous diets than mink rats in human-affected areas," said Erin McKenney, assistant professor of applied ecology at North Carolina State University and co-first author of the study.
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Developmental Cell: Reveal the molecular mechanism of salt avoidance in plant roots
Time of Update: 2022-11-15
The salinization of soil in China leads to insufficient arable land, which affects the effective supply of food. Exploring the sensing mechanism of plants to salt stress and elucidating the strategie
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Inflammation amplifies the effects of genetic risk variants for schizophrenia
Time of Update: 2022-11-15
Researchers at the Karolinska Institutet now report that Nature Communications in first-time patients saw elevated levels of proteins from associated risk genes and inflammation further increasing the expression of risk genesIn the brain in late adolescence, suboptimal connections between nerve cells are eliminated normally.
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The University of Science and Technology of China/Shenzhen Advanced Institute of the Chinese Academy of Sciences has made an important breakthrough in the development of cryo-EM in situ imaging technology
Time of Update: 2022-11-15
The team of Bi Guoqiang, a dual-appointed professor from the University of Science and Technology of China and the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, cooper
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During the 2021-2022 influenza season, the prevalence of COVID-19 and influenza co-infections was high
Time of Update: 2022-11-15
SARS-CoV-2 and influenza co-infection: A cross-sectional study in central Missouri during the 2021–2022 influenza season Researchers at the University of Missouri School of Medicine found that during the 2021-2022 flu season, the prevalence of COVID-19 co-infections in central Missouri was high, with a monthly co-infection rate of up to 48% for COVID-19 patients.
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Nature reports that the core function of innate immune cells, where does inflammation and mucus come from?
Time of Update: 2022-11-15
Non-redundant functions of group 2 innate lymphoid cells Role of ILC2 in infection: cross-section of the small intestine after infection with Strongyloides brasilensis.
Non-redundant functions of group 2 innate lymphoid cells Role of ILC2 in infection: cross-section of the small intestine after infection with Strongyloides brasilensis.
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Programmable "discharge" bacteria
Time of Update: 2022-11-15
Parker-like bioelectronic devices designed by Rice University contain programmable bacteria and are connected to an electrode that sends signals when they detect a target contaminant for real-time sensing.
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Romantic first impressions matter
Time of Update: 2022-11-15
In other words, they looked at the patterns of initial desires observed in speed dating and assessed whether these factors differently predicted whether people would later develop relationships with potential partners they met.
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Neural connections with age-related decline
Time of Update: 2022-11-15
The two, friends who have collaborated for years while pursuing their degrees, are using animal and human models to study the role that the blue-spotted circuit plays in age-related cognitive decline.
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Is it useful to store immune cells? A few true stories to tell you the truth!
Time of Update: 2022-11-15
The advent of immune cell therapy has created countless miracles of life, brought the light of life to some patients with malignant tumors, and opened a new chapter in cancer treatment.
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The Wu Yijun research team of the Institute of Zoology found that ivermectin can be used to fight tumor metastasis
Time of Update: 2022-11-15
pdf Fig. 1 Schematic diagram of the mechanism of action of ivermectin against cancer cell metastasis Cancer is one of the important diseases that endanger public health, and its morbidity and mortality rate are increasing year by year.
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Martin's group in the School of Chemistry published a review of cross-scale metal catalyst group effects in Nature Catalysis
Time of Update: 2022-11-15
In view of the understanding of cross-scale metal catalyst structure-activity relationship and the design of efficient catalysts, Professor Martin's research group from the School of Chemistry and Molecular Engineering of Peking University was invited to publish a review article entitled "Ensemble effect for single-atom, small cluster and nanoparticle catalysts" in Nature Catalysis.
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The gene Wnt4 becomes active after sensing β cells
Time of Update: 2022-11-15
In a recent study by Nature Communications Anne Grapin-Botton, director of MPI-CBG, she and her team in Dresden and the team at the Novo Nordisk Foundation Center for Stem Cell Biology in Copenhagen, Denmark, and colleagues from Carl Gustav Carus from the Technical College of Dresden found that the gene Wnt4 becomes active in food-sensing β cells as they mature in life early after birth.
