First Science and then Cell, the mechanism of eating less to prolong life has been found, reducing proteins related to the aging process

Aging is a complex, multi-stage, gradual process that occurs throughout
life.
With the passage of time, the organs and muscles of the human body will gradually age, and some diseases will occur with age, including cancer, diabetes, cardiovascular diseases, etc
.

In recent years, fasting has become a new favorite in the scientific community, including time-restricted fasting, calorie-restricted diet, etc
.
Fasting has been shown to lose weight and extend animal lifespan, in fact, a growing body of research shows that fasting has many health benefits, improving metabolic health, preventing or delaying diseases that come with aging, and even slowing tumor growth
.

Professor Vishwa Deep Dixit of Yale University School of Medicine and others published a research paper
titled "The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging" in the journal Cell sub-journal "Immunity".

The study discovered the mechanism of eating less to prolong life, and moderate calorie restriction reduces the production of the aging process-related protein SPARC, which inhibits harmful inflammation, improves metabolism, and extends healthy lifespan
with age.

Calorie restriction has been a hot spot
in longevity studies.
Reducing caloric intake has been shown to extend the lifespan of many animals, including fruit flies, nematodes, mice, and non-human primates
.

Professor Vishwa Deep Dixit of Yale University in the United States published a research paper
entitled "Caloric restriction in humans reveals immunometabolic regulators of health span" in the top international journal "Science".

The study, the first to show in humans, that calorie restriction can improve metabolism and immune response, helping to improve human health and longevity, and the study also identified PLA2G7
, a key protein that can be used to prolong human health.
(Read More)

In the new study, the researchers further analyzed data from the two-year clinical trial, Comprehensive Evaluation of the Long-Term Effects of Reducing Energy Intake (CALERIE), a National Institutes of Health-funded clinical trial that is the first randomized controlled study
of calorie restriction in healthy humans.

In the experiment, some participants reduced their calorie intake by 14 percent per day for two years, while others ate as usual, and the researchers analyzed the long-term health effects
of calorie restriction over the next two years.

After one and two years of the experiment, the researchers analyzed genetic changes in the participants' adipose tissue to identify molecules
that restricted caloric intake had a positive effect and could be targeted for treatment.

The analysis found that those who consumed fewer calories had significantly lower levels of protein in SPARC, an acidic secreted protein rich in cysteine, and obesity increased SPARC levels, which has been linked
to obesity, diabetes, and inflammation.

It is well known that inflammation plays an important role in age-related decline, and the researchers further analyzed whether longevity interventions like calorie restriction control inflammation and immune responses
through SPARC.

To delve into the effects of SPARC on inflammation, the researchers analyzed the effects of
SPARC on mouse immune cells and mouse health.

The study found that SPARC transformed anti-inflammatory macrophages into a pro-inflammatory phenotype
by inducing interferon-stimulated gene expression through the transcription factor IRF3/7.

SPARC converts M2 macrophages to a pro-inflammatory form

In addition, reducing the SPARC produced by mouse fat cells reduced inflammation, improved metabolism, and extended their healthy lifespan
with age.

SPARC is reduced, improving health during aging

The researchers say that with the study, we have a better understanding of how SPARC affects inflammation and health by acting on macrophages, and these findings may help prevent age-related decline
.
And it could be an effective target for inducing the health benefits of calorie restriction without altering calorie intake
.

Overall, studies have shown that caloric restriction reduces the production of the aging process-related protein SPARC, an immunometabolic checkpoint for inflammation and interferon responses that can be used to delay age-related metabolic and functional decline
.