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The latest research progress of CRISPR/Cas in 2022
Time of Update: 2023-01-01
In a second new study, researchers from the Massachusetts Institute of Technology in the United States and the University of Tokyo in Japan found that the type III-E CRISPR system includes the proteinease Csx29, similar to caspase, which is activated to cleave another helper protein called Csx30 when Cas7-11 recognizes the target RNA.
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JACC: Falling off the altar, good cholesterol does not reduce the risk of heart disease
Time of Update: 2023-01-01
Researchers from the University of Vermont and Oregon Health and Science University published a research paper titled "Race-Dependent Association of High-Density Lipoprotein Cholesterol Levels With Incident Coronary Artery Disease" in the journal "JACC" of the American College of Cardiology。The study showed that good cholesterol does not prevent cardiovascular disease risk and even increases it.
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November 2022 Science Journal Highlights
Time of Update: 2023-01-01
November 2022 is coming to an end, what are the highlights of the Science journal worth learning in November? The editor has sorted out this and shared it with you. 1. Science: The universal flu vacc
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Nature: Why does fat increase after dieting? How protein helps with weight loss
Time of Update: 2023-01-01
A study led by Professor Zhai Qiwei of the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, published in the journal Nature Metabolism, showed that the increase in lactic acid bacteria and their metabolites after dieting enhanced intestinal lipid absorption in mice, leading to rapid fat accumulation and obesity.
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Entering the Expo, Double 11 Double End! Sailifu AI multi-target anti-aging technology attracts attention
Time of Update: 2023-01-01
AI multi-target anti-aging technology innovation leadsSince the establishment of the brand, Sailifu has adhered to scientific research as the foundation and established a "health system" integrated with three major centers: scientific research center, product center and health center, and the scientific research center covers four major anti-aging research platforms: holographic aging big data analysis platform, core raw material selection platform, advanced preparation process research and development platform, and systematic testing application platform, with profound scientific research achievements.
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The Chinese Agricultural Society organized and held a scientific and technological achievement evaluation meeting of the academician Yin Yulong team
Time of Update: 2023-01-01
Outcome evaluation meeting site On December 5th, experts from the Chinese Agricultural Society organized experts to evaluate the scientific and technological achievements of "Analysis and Intervention of Nutritional Diarrhea Mechanism and Intervention of Piglets Key Technological Innovation and Application" completed by the team of Academician Yin Yulong of the Institute of Subtropical Agroecology, Chinese Academy of Sciences.
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Nat Med: Identifies specific genes that control the body's metabolic personality and risk of developing disease
Time of Update: 2023-01-01
The concept of "chemical individuality" proposed by British scientist Archibald Edward Garrod helps to understand the molecular origin of human disease, and non-targeted high-throughput metabolomics
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Clin Transl Immunol: Using cancer immunotherapy technology to develop immunotherapies with the potential to treat SARS-CoV-2 infection
Time of Update: 2023-01-01
Instead of having cells outside the body genetically engineered to kill infected cells, this ACE2-bispecific antibody therapy activates healthy T cells in the individual to target host cells that present the SARS-CoV-2 spike protein after infection.
com)Resources:Mikail Dogan et al.
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The FDA asked Verve to provide evidence of whether its base-editing treatment would be passed on to offspring
Time of Update: 2023-01-01
Verve-101 is the first in vivo base editing therapy to enter the clinic, VERVE-101 therapy aims to permanently turn off the expression of the PCSK9 gene in the liver through a base editor delivered by lipid nanoparticles (LNP), thereby reducing low-density lipoprotein cholesterol (LDL-C) to enable the prevention and treatment of cardiovascular diseases including heterozygous familial hypercholesterolemia (HeFH).
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Can you lose weight by smelling meat? Nature sub-issue: "Odor Therapy" can promote lipid metabolism and easy weight loss, or a gospel for people who have difficulty losing weight!
Time of Update: 2023-01-01
Intermittent fasting (24 h twice a week) was found by intermittent fasting (24 h twice a week) on mice on a high-fat diet (HFD), that HFD odor stimulation had no additional effect on body weight and food intake, but reduced blood glucose levels.
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Nature: Shocked! Revealing a new mechanism by which V-ATPases in mammalian brains transition between two different states
Time of Update: 2023-01-01
In a new study, researchers from the University of Copenhagen in Denmark have made a breakthrough in further understanding the mammalian brain, and they have made an incredible discovery: An important enzyme that activates brain signals is randomly turned on and off, and even subjected to "rest periods" of up to several hours.
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Cell Rep: Uncovering a novel mechanism by which HIV-1 evades attack by the host body's immune system
Time of Update: 2023-01-01
Recently, a study entitled "HIV-1 Vpu restricts Fc-mediated effector functions in vivo" published in the international journal Cell Reports, scientists from the University of Montreal and other insti
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A breakthrough has been made in the mining of goat characteristic genetic resources in China
Time of Update: 2023-01-01
The study reported a new selected gene PAPSS2 in the genome of Tibetan goats, and further analysis found that the gene originated from gene influx of a related species of goats in the Himalayas, an ancient gene infiltration event that helped goats quickly adapt to the harsh natural environment of the plateau at an early stage.
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Nat Metabol: The gut microbiome plays a special role in shaping the body's blood metabolome
Time of Update: 2023-01-01
com)Original source:Christian Diener, Chengzhen L Dai, Tomasz Wilmanski, et al.
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JCI: New Discovery! A Parkinson's disease drug itraphylline may be expected to reduce the side effects of cisplatin chemotherapy!
Time of Update: 2023-01-01
Cisplatin is a chemotherapy that helps ward off tumors in many types of cancer, however, it can also have significant side effects, especially kidney toxicity, often leading to acute kidney failure 。 In addition, patients treated with cisplatin often exhibit high levels of neuropathic pain, and a paper published in the Journal of Clinical Investigation titled "Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while.
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Nat Commun: A new perspective on antibiotic resistance research! For the first time, scientists have discovered that drug-resistant bacteria may be able to transfer from the intestines to the lungs, increasing the risk of fatal infections!
Time of Update: 2023-01-01
1038/s41467-022-34101-2 Bacteria have the potential to move between different parts of the human body, but researchers still know little about the dynamics of bacterial migration within the host organism and the consequences thereof 。 Recently, a study entitled "Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient" was published in the international journal Nature Communications.
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To save nature, we need to focus on people, not species
Time of Update: 2023-01-01
" ”essayGreater evolutionary divergence of thermal limits within marine than terrestrial species Atlantic killifish, produced on the Atlantic coast from Florida to Canada.
" ”essayGreater evolutionary divergence of thermal limits within marine than terrestrial species Atlantic killifish, produced on the Atlantic coast from Florida to Canada.
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A novel mechanism by which PPDPF regulates pancreatic ductal adenocarcinoma
Time of Update: 2023-01-01
202202448 On December 1, 2022, the international academic journal Advanced Science published online the title "PPDPF promotes the development of mutant KRAS-driven pancreatic ductal adenocarcinoma by regulating the GEF activity of" by Xie Dong Research Group, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences SOS1".
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Acta Pharmaceutica Sinica B: PROTAC technology as a new tool for the identification of diterpenoid targets
Time of Update: 2023-01-01
1 mm o l/L, but its exact target and anti-inflammatory mechanism still need further study 。V-MAF Aponeural fibrosarcoma oncogene homologous F (MAFF) belongs to the small MAFS family of proteins, which also includes MAFG and MAFK, and is a basic region leucine zipper (BZIP) transcription factor lacking trans-activating domains.
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Dengue vaccine! Qdenga (TAK-003, live attenuated quadrivalent vaccine) enters priority review in the United States!
Time of Update: 2023-01-01
S. Food and Drug Administration (FDA) has accepted the Biologics License Application (BLA) for TAK-003 (Dengue Quadrivalent Vaccine [Live Attenuated Vaccine]) for priority review for use in people aged 4 to 60 years to prevent dengue disease caused by any dengue virus serotype.
