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A novel mechanism by which PPDPF regulates pancreatic ductal adenocarcinoma
Time of Update: 2023-01-01
202202448 On December 1, 2022, the international academic journal Advanced Science published online the title "PPDPF promotes the development of mutant KRAS-driven pancreatic ductal adenocarcinoma by regulating the GEF activity of" by Xie Dong Research Group, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences SOS1".
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Clin Transl Immunol: Using cancer immunotherapy technology to develop immunotherapies with the potential to treat SARS-CoV-2 infection
Time of Update: 2023-01-01
Instead of having cells outside the body genetically engineered to kill infected cells, this ACE2-bispecific antibody therapy activates healthy T cells in the individual to target host cells that present the SARS-CoV-2 spike protein after infection.
com)Resources:Mikail Dogan et al.
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Nat Metabol: The gut microbiome plays a special role in shaping the body's blood metabolome
Time of Update: 2023-01-01
com)Original source:Christian Diener, Chengzhen L Dai, Tomasz Wilmanski, et al.
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Nature: Shocked! Revealing a new mechanism by which V-ATPases in mammalian brains transition between two different states
Time of Update: 2023-01-01
In a new study, researchers from the University of Copenhagen in Denmark have made a breakthrough in further understanding the mammalian brain, and they have made an incredible discovery: An important enzyme that activates brain signals is randomly turned on and off, and even subjected to "rest periods" of up to several hours.
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A breakthrough has been made in the mining of goat characteristic genetic resources in China
Time of Update: 2023-01-01
The study reported a new selected gene PAPSS2 in the genome of Tibetan goats, and further analysis found that the gene originated from gene influx of a related species of goats in the Himalayas, an ancient gene infiltration event that helped goats quickly adapt to the harsh natural environment of the plateau at an early stage.
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The FDA asked Verve to provide evidence of whether its base-editing treatment would be passed on to offspring
Time of Update: 2023-01-01
Verve-101 is the first in vivo base editing therapy to enter the clinic, VERVE-101 therapy aims to permanently turn off the expression of the PCSK9 gene in the liver through a base editor delivered by lipid nanoparticles (LNP), thereby reducing low-density lipoprotein cholesterol (LDL-C) to enable the prevention and treatment of cardiovascular diseases including heterozygous familial hypercholesterolemia (HeFH).
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Acta Pharmaceutica Sinica B: PROTAC technology as a new tool for the identification of diterpenoid targets
Time of Update: 2023-01-01
1 mm o l/L, but its exact target and anti-inflammatory mechanism still need further study 。V-MAF Aponeural fibrosarcoma oncogene homologous F (MAFF) belongs to the small MAFS family of proteins, which also includes MAFG and MAFK, and is a basic region leucine zipper (BZIP) transcription factor lacking trans-activating domains.
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Can you lose weight by smelling meat? Nature sub-issue: "Odor Therapy" can promote lipid metabolism and easy weight loss, or a gospel for people who have difficulty losing weight!
Time of Update: 2023-01-01
Intermittent fasting (24 h twice a week) was found by intermittent fasting (24 h twice a week) on mice on a high-fat diet (HFD), that HFD odor stimulation had no additional effect on body weight and food intake, but reduced blood glucose levels.
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Frontiers in Marine Science: The first to reveal the diversity and geographical distribution of the world's pomfret species
Time of Update: 2022-12-30
Geographical distribution pattern and differentiation time and biogeographic reconstruction of seven pomfret species (bottom) Recently, the fish classification and phylogeny research team of the Institute of Oceanography of the Chinese Academy of Sciences has made new progress in the study of the classification and geographical distribution pattern of fish in the world pomfret (Pampus) of the world pomfret family.
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Nature sub-issue: New assembly tool leads to more accurate Mycobacterium tuberculosis genome
Time of Update: 2022-12-30
Nowadays, when sequencing new bacterial genomes, it is common to break long DNA fragments into small fragments that can be scanned quickly, and then assemble all the resulting data correctly using a reference sequence such as H37Rv. However, Bact-Builder used long-read, long-read data generated by the MinION sequencer to assemble the genome without a reference, which could help researchers identify genes that only exist in clinical strains.
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Molecular Cell: Uncovering new strategies for pathogenic infections
Time of Update: 2022-12-30
Professor Li Shan's research group, College of Life Science and Technology, School of Biomedicine and Health, Huazhong Agricultural University, and Fu Xuan's research group of Southern University of
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The oceans use gene editing technology to obtain high-quality insect-resistant new germplasm of economic microalgae
Time of Update: 2022-12-30
Recently, the algae physiological process and precision design breeding research team of the Institute of Oceanography of the Chinese Academy of Sciences has made new progress in the research of gene
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Nature Medicine: Serotonin 2C receptors are associated with childhood obesity
Time of Update: 2022-12-30
The results, titled "Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior," were published this week in the journal Nature Medicine and have diagnostic and therapeutic implications.
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The research groups of Peng Hailin, Wang Hongwei and Wei Xiaoding collaborated to develop ultra-flat graphene for high-resolution cryo-EM imaging
Time of Update: 2022-12-30
Single particle cryo-EM is one of the important means to reveal the fine structure and reaction mechanism of biological macromolecules. The preparation of a uniform thin ice layer can significantly i
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"Nature" published an article by Peking University to reveal the immune microenvironment subtypes of liver cancer
Time of Update: 2022-12-30
The Zhang Ning team of the Cancer Translational Research Center of Peking University First Hospital worked closely with the team of Zhang Zemin of the Biomedical Frontier Innovation Center (BIOPIC) of Peking University and the team of Zhu Jiye of the Department of Hepatobiliary Surgery of Peking University People's Hospital Nature) published a research paper entitled "Liver tumor immune microenvironment subtypes and neutrophil heterogeneity.
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Guangzhou Health Center revealed the molecular mechanism of bacterial type VI. secretion effector protein RhsP targeting prey cells
Time of Update: 2022-12-30
Recently, the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences and the University of Macau jointly published a report entitled Vibrio parahaemolyticus prey targeting require
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The Hong Kong Polytechnic University draws world's first "atlas" of airborne microorganisms
Time of Update: 2022-12-30
The team analyzed bacterial communities of 370 individual airborne particle samples collected from 63 sites around the world, from the ground to the top of a mountain, and from densely populated urban centers to the Arctic Circle.
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Which diet is better for weight loss and diabetes control, low carbohydrate or low fat?
Time of Update: 2022-12-30
References: A low-carbohydrate diet can help people with diabetes lose weight better and control their blood sugar compared to a low-fat diet.
References: A low-carbohydrate diet can help people with diabetes lose weight better and control their blood sugar compared to a low-fat diet.
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A new theory of sudden cardiac death
Time of Update: 2022-12-30
This can lead to sudden cardiac death, usually during exercise," says Volker Spindler, anatomist and head of the Cell Adhesion Group at the Department of Biomedical Sciences at the University of Basel.
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Fudan University published a preprint: neutralizing antibodies that are effective against new crown mutant strains
Time of Update: 2022-12-30
The scientific research team composed of Wang Qiao's laboratory and Ai Di Weixin Biopharmaceutical of Fudan University School of Basic Medicine discovered a broad-spectrum neutralizing antibody XG005, which is highly effective against all domestic new crown mutant strains, and verified through experiments that it has super high neutralizing activity against various strains such as new coronavirus wild type, Alpha, Beta, Gamma, Delta, OmicronBA.
