The latest research has found new evidence of traditional Chinese medicine to delay brain aging

Recently, a new study entitled "Bazi Kidney Supplement Capsules Alleviates Cognitive Dysfunction by Inhibiting Microglia Activation and Cell Senescence" published in the well-known British journal "Pharmaceutical Biology", introducing that Bazi Kidney Supplement Capsules can significantly improve cognitive dysfunction, providing experimental evidence
for the wide application of traditional Chinese medicine in the clinical practice of cognitive dysfunction.

As the human body ages, brain function gradually declines, manifested as cognitive dysfunction
such as memory, learning, exploration, and motor coordination.
These phenomena have increased the incidence
of neurodegenerative diseases such as Alzheimer's, stroke and Parkinson's disease.

The pathogenesis of neurodegenerative diseases is complex, cell senescence is one of the signs of body aging, can promote body aging through a variety of ways, senescent cells release inflammatory factors in autocrine, paracrine ways to strengthen the aging phenotype, and senescent cells will affect tissue regeneration by limiting cell proliferation ability, resulting in tissue and body dysfunction
.
Therefore, by removing or regulating senescent cells is an important way
to prevent brain aging.

The study "Bazi Kidney Supplement Capsule alleviates cognitive dysfunction by inhibiting microglia activation and cell aging" not only observed that cellular senescence participated in the occurrence of inflammation-induced cognitive dysfunction in aging mice, but more importantly, confirmed that Bazi Kidney Supplement Capsule can improve inflammation-induced cognitive dysfunction in aging mice by reducing cellular senescence
.

It is reported that the research team successfully established a mouse model of D-gal-induced aging, which is manifested by hair loss, learning memory and decreased motor ability
.
A decrease in the number of neurons and Nithrosomes, structural abnormalities, decreased density and plasticity of synapses connecting neurons, and activation and polarization
of microglia, the main source of neuroinflammation, in the brain were observed in the cortical and hippocampal regions of the mouse model brain.
In addition, upregulation of the cell cycle arrest protein p16INK4a, downregulation of the cell proliferation protein PCNA, and increased
aging-associated secretion phenotype (SASP) factor were observed in the cortical and hippocampal regions of the mouse model brain.

The results showed that the continuous application of Bazi Kidney Supplement Capsules for 60 days could effectively improve the coat loss, cognitive dysfunction and age-related index abnormalities
of D-gal-induced aging mice.
Bazi Kidney Supplement Capsule can protect neuronal damage, reduce synaptic density and plasticity decline, inhibit microglial activation, block the polarization of microglia from neuroprotective phenotype to neuroinflammatory phenotype, these effects may be related to
the drug's reduction of cellular aging.

The study provides evidence
for the treatment of age-related cognitive dysfunction with Bazi Kidney Supplement Capsules.
At present, the team is also carrying out a large number of research
on the prevention and treatment of neurodegenerative diseases of Bazi Kidney Supplement Capsules.