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Twin studies show that environmental factors play an important role in the pathology of Alzheimer's disease
Time of Update: 2022-01-08
Professor Perminder Sachdev said: " Identifying the risk factors that can be changed will lead us to take active interventions to reduce the risk of amyloid accumulation-and ultimately reduce the risk of Alzheimer's disease .
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JNNP: Are you craving more sweets after receiving deep brain stimulation in the subthalamic nucleus?
Time of Update: 2022-01-08
Compared with OFF, the comparison of salty foods in the right occipital cortex, bilateral NAcc, left putamen and left insula under ON conditions with neutral images found the same stimulation effect (P FDR corr ≤0.
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Mol Psychiatry: Stress-related diseases should pay more attention to the family environment
Time of Update: 2022-01-08
Mol Psychiatry published a research article, through the analysis of genetic and early environmental factors, to investigate whether parental/perinatal adversity will cause offspring to have a higher risk of stress-related diseases in later life .
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Front.aging-neurosci-FGF21 regulates microglia polarization and attenuates neurodegeneration in mice and cell models of Parkinson’s disease
Time of Update: 2022-01-08
FGF21 inhibits MPTP-injured NF-κB pathway in mice and enhances M2 microglia polarizationFGF21 significantly reduced the gene expression of M1 microglia markers IL-1β, TNF-α and CD 68 (Figure 2A) .
In summary, in this study, the authors showed for the first time that FGF21 significantly reduced MPTP-induced motor symptoms and cognitive dysfunction in mice .
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Stroke: How does long-term cognitive function change after a stroke
Time of Update: 2022-01-08
A one-step meta-analysis of individual participant data was used to study the rate of change of cognitive function and risk factors for cognitive decline after stroke .
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Neurology: Dual-energy CT features of high-density subarachnoid space after thrombus removal in acute stroke—diffuse mode is associated with poor clinical prognosis
Time of Update: 2022-01-07
This study provides Class II evidence that in patients with proximal carotid artery occlusion who received mechanical thrombectomy, diffuse subarachnoid high density at 8 hours after intervention was associated with poorer clinical outcomes 90 days later .
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JAMA Neurol: Drug-eluting stents can significantly reduce the risk of intrastent stenosis and stroke recurrence in patients with high-grade ICAS!
Time of Update: 2022-01-07
In order to study whether DES can reduce the risk of ISR and stroke recurrence in symptomatic high-grade ICAS patients , experts from the Department of Neurology, Tiantan Hospital, Capital Medical University of China, carried out related research, and the results were published in JAMA Neurology .
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Neurology: A powerful biomarker for stroke prognosis-low brown-yellow outer mitochondrial DNA copy number (mtDNA-CN) may be related to poor baseline severity and prognosis after 1 month!
Time of Update: 2022-01-07
This study provides Class II evidence that low-brown-yellow coat mtDNA-CN (>1 standard deviation) in patients with ischemic or hemorrhagic stroke is associated with poor baseline severity and 1-month prognosis .
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The young guy suddenly "dementia", again this common medicine!
Time of Update: 2022-01-05
In fact, regarding metronidazole-induced encephalopathy, "Medical Neurology Channel" has reported several cases: the patient's sudden speech is slurred, gait wobbly.
Combined with the patient’s medical history, clinical symptoms, cranial MRI findings, and symptoms significantly improved after stopping metronidazole, the patient was diagnosed with Metronidazole-Induced Encephalopathy (MIE) .
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How to diagnose and treat transient ischemic attack in the early stage depends on the Chinese guidelines!
Time of Update: 2022-01-05
Within 2 to 7 days after the onset of TIA is the high-risk period of stroke, optimize the allocation of medical resources, and establish emergency medical care based on the ABCD2 score (Table 1) stratification and imaging Mode, start TIA assessment and secondary prevention as soon as possible .
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Express significantly improved the symptoms of exercise and drowsiness in patients with Parkinson's disease, and the new compound preparation reached the key phase 3 clinical endpoint
Time of Update: 2022-01-05
In addition, P2B001, compared with the marketed pramipexole sustained-release therapy, has a similar curative effect, significantly reducing the symptoms of daytime sleepiness in patients, and is accompanied by superior safety .
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A 10-year-old boy with developmental delay + mental abnormality, this case is said to be undiagnosed by 60% of doctors!
Time of Update: 2022-01-04
Viral encephalitis is manifested as a high signal on the T2 image, involving the deep gray matter and white matter of the brain, including the cerebellum and brainstem .
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Nature Human cortex precursor cells can produce excitatory and inhibitory neurons
Time of Update: 2022-01-03
Research on neurodevelopment in rodents suggests that the two main cortical neurons-glutamatergic excitatory neurons and GABA inhibitory interneurons are produced by two different precursor cells [1 -2] .
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The risk of dementia is hidden in the heart rate!
Time of Update: 2022-01-01
A recent study published in the journal Alzheimer's & Dementia[3] found that among elderly people 60 years of age and older, the resting heart rate ≥80 beats per minute (bpm) is between 60-69 bpm.
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Express to further test the Aduhelm effect, Bojian plans to start confirmatory clinical trials
Time of Update: 2022-01-01
▎Editor of WuXi AppTec content team On December 16, 2021, Biogen and Eisai announced that they are expected to start a large confirmatory clinical trial in May next year to further evaluate Alzheimer’s The efficacy of monoclonal antibody therapy Aduhelm (aducanumab) for disease (AD) .
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Which medicine should be used for mild and moderately severe "herpes zoster postherpetic neuralgia"?
Time of Update: 2021-12-31
Professor Wang Yu mentioned that timely and effective antiviral treatments, especially those administered within 72 hours of the appearance of the rash, can prevent PHN .
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Treat rare diseases!
Time of Update: 2021-12-31
December 18, 2021/MedClub News/--On December 16, 2021, gene therapy company uniQure announced its ongoing Phase I/II clinical trial of AMT-130 for the treatment of Huntington’s disease, recruiting Preliminary observations of the first four patients in the low-dose cohort .
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Nature: Break the traditional cognition!
Time of Update: 2021-12-31
Nowakowski, Department of Anatomy, University of California, discovered that by developing a molecular barcode tool to track the differentiation of radial glial cells, it was found that human cortical progenitor cells can differentiate into inhibitory neurons .
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The middle-aged man has intermittent convulsions, difficulty walking, dementia...don't miss the cause!
Time of Update: 2021-12-31
About 80% of patients have a family history, all of which are maternal inheritance, mitochondrial dysfunction, insufficient ATP production, and enhanced tissue anaerobic metabolism; ②Clinical manifestations are muscle Clonus, epilepsy, ataxia, dementia, limb weakness, exercise intolerance; ③Laboratory examination of blood gas lactic acid levels increased, and electromyography showed myogenic or neurogenic damage .
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Concentric sclerosis-this case will definitely give you a lot of rewards!
Time of Update: 2021-12-31
08 enhanced MRI + MRS + enhanced scan: bilateral frontal and parietal lobes, basal ganglia, corpus callosum pressure and left occipital lobe have multiple abnormal signals, the NAA value of the area of interest is reduced, and demyelinating diseases, concentric sclerosis should be considered more The possibility is high, please combine clinical and laboratory examinations .
