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How to resist cognitive decline in the brain? Cai Lihui's team found a new treatment target
Time of Update: 2021-11-14
In mice living in a rich environment, the activity of this transcription factor in neurons is particularly high; and in patients with Alzheimer's disease whose cognitive function remains normal, many downstream genes regulated by MEF2 show enhanced expression, and The transcriptional activity of MEF2 can strongly predict the end-stage cognitive performance of patients .
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Blockbuster Alzheimer's disease may be cured: The latest findings of this California-based cell therapy company are inspiring
Time of Update: 2021-11-14
GABAeron scientists successfully differentiated GABAergic interneuron precursor cells from human iPSCs, and showed that when these cells were transplanted into a mouse model of Alzheimer’s disease carrying APOE4 (apolipoprotein E4, the main genetic risk factor) When in the brain, these cells can mature and integrate into the hippocampus, reversing the hippocampal network dysfunction associated with Alzheimer’s disease .
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Nature: In addition to energy disorders, damage to mitochondria can also cause other kinds of Parkinson-like dyskinesias
Time of Update: 2021-11-14
Researchers found that 1-month-old mice (hereinafter referred to as Ndufs2-specific knockout mice) after specifically knocking out the Ndufs2 encoding the MCI gene on dopaminergic neurons lost the ability of motor learning and showed severe fine motor dysfunction; Severe motor dysfunction began to appear after the 40th day, and then became more and more serious.
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Fight poison with poison, cure brain cancer with virus!
Time of Update: 2021-11-14
It is reported that in June of this year, the oncolytic virus therapy Delytact received conditionaland time-limited approval from the Ministry of Health, Labour and Welfare (MHLW) for the treatment of malignant glioma.
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PNAS︱Qin Hongtao/Chen Peng's research group collaborated to reveal that dopaminergic neurons regulate chronic stress-induced memory impairment in Drosophila
Time of Update: 2021-11-14
This paper reported for the first time that chronic stress-induced learning deficit (CSLD) is related to the depression-like state of Drosophila melanogaster, and initially revealed the neural circuit mechanism of the dopamine nervous system that regulates susceptibility to CSLD .
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The diversity of cells in the sponge sheds light on the evolution of the nervous system｜Science Weekly Selection
Time of Update: 2021-11-14
According to a new study, the specialized cells in the digestive chamber of the sponge (our furthest animal relative) may represent the starting point of the evolution of the nervous system .
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Sci Adv Osteocalcin regulates the differentiation and myelination of oligodendrocytes in the central nervous system through GPR37
Time of Update: 2021-11-14
In this study, the use of knockout mice and primary cell culture analysis found that OCN has an important regulatory effect on the differentiation and myelination of oligodendrocytes in the central nervous system, and discovered and preliminarily identified the functions of OCN in the central nervous system.
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Chinese scientist team Cell sub-Journal publishes research results on the pathogenesis of high-functioning autism genes
Time of Update: 2021-11-14
The research team used virus stereotactic injection technology combined with animal behavior experiments and found that replenishing SENP1 protein or FMRP protein in the RSA brain area can effectively improve the core symptoms of autism in Senp1 heterozygous mice .
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Cell Metabolism Chill stimulates the immune system and relieves inflammation of the nervous system
Time of Update: 2021-11-14
On this basis, the authors found that cold exposure reduces the expression of MHCII in mouse Ly6Chi monocytes, but does not affect other immune cell populations .
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Nature: Why am I crazy?
Time of Update: 2021-11-14
The choice of the future trajectory not only depends on the spatial location information of the hippocampus, but also depends on the cortex, the brain area involved in the evaluation and selection, to jointly decide where to go next .
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Express delivery gives patients more time to spend with their families, and the innovative treatment of "gradual freezing syndrome" is one step closer to being approved
Time of Update: 2021-11-14
▎The content team editor of WuXi AppTec recently announced that Amylyx Pharmaceuticals has submitted a New Drug Application (NDA) for AMX0035 to the US FDA for the treatment of amyotrophic lateral sclerosis (ALS) .
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Do you think you have a headache?
Time of Update: 2021-11-14
Case review: The patient, a young female, complained of pain and discomfort in the left neck, which lasted for 1 week in the left shoulder .
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Nature Sub-Journal: Born in sorrow and dying in happiness, the stimulating environment keeps the brain young
Time of Update: 2021-11-14
Through single-nucleotide resolution whole-genome DNA methylation sequencing, it is proved that high stimulation environment can also restore a large number of age-related DNA methylation changes in the hippocampus of the brain .
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PNAS breakthrough!
Time of Update: 2021-11-14
Figure 1 Optogenetic activation of glutamatergic neurons in CnF of Vglut2-ChR2-EYFP mice modeled by 6-OHDA improves the motor function of mice (Source: Fougère, Maxime et al.
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Nat Commun and Xiong Wei's research team analyze the "shocked" neural circuit
Time of Update: 2021-11-14
Researchers first used c-fos staining and in vivo calcium signal recording and found that sound-induced startle reflex (ASR) causes glutamatergic neurons in the pontine caudal nucleus (Reticulotegmental nucleus, RtTg) Activated by a large amount, the calcium signal is significantly enhanced (Figure 1) .
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We have just learned the development process of this terrible disease...
Time of Update: 2021-11-14
This type of method is very effective for studying certain aspects of this disease, such as understanding the influence of genetic factors; but for the entire disease, laboratory animal models are not the best choice, partly because of Alzheimer’s The development time of sick people from the initial mild symptoms to the final death can usually last for decades, and the research time provided by laboratory animals is much shorter than this .
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Why did this little boy sit up screaming in the middle of the night?
Time of Update: 2021-11-14
I told her that the child may have night terrors, a form of sleep disorder .
If the child has frequent night terrors, he still hopes to undergo further examinations of the nervous system and sleep .
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How to treat "delayed dyskinesia" caused by antipsychotics?
Time of Update: 2021-11-14
012 definitions to understand ▌ Tardive Dyskinesia (TD) TD was originally used to describe the rhythmic, repetitive (stereotypical), continuous movement that occurs after prolonged exposure to antipsychotic drugs .
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The incidence of Guillain-Barré syndrome and major neuroimmune diseases in my country has been completed
Time of Update: 2021-11-14
Shi Fudong) Based on HQMS, Professor Shi Fudong’s team has completed major neuroimmune diseases Including multiple sclerosis, optic neuromyelitis spectrum diseases, myasthenia gravis, acute disseminated encephalomyelitis, and Guillain-Barré syndrome annual incidence, average hospitalization costs and other clinical indicators survey and report (Table 1) .
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Tsinghua Xiong Wei's Review: Drawing of Single Cell Expression Profile Related to DRG Neuron's Mechanical Sensitivity
Time of Update: 2021-11-14
To sum up, this work uses Patch-seq technology to make a single-cell-scale transcriptional spectrum annotation for the mechano-sensitive current dynamics of DRG neurons, providing researchers in the field An open data set for the study of candidate genes for the DRG neuron mechanical sensitive channel .
