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Cell Rep︱ new research reveals the role of hypothalamic neuronal calcium homeostasis regulators in the formation of obesity
Time of Update: 2021-11-15
, Cell Reports, 2021) Figure 5 Work summary diagram: The role of Stim1-Oas3 signaling pathway in hypothalamic AgRP neurons in the formation of nutritional obesity in mice (Source: Zhuo Chen, et al.
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Science journal: Subverting the cognition of the development process of Alzheimer's disease, the toxic protein blooms more and more, and it keeps replicating
Time of Update: 2021-11-15
But this latest study shows that the toxin protein that causes Alzheimer’s disease does not start from a single point in the brain and triggers a chain reaction that causes brain cell death, but exists in different areas of the brain in the early stage, and over time Continue to replicate and expand .
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On World Stroke Day to prevent stroke, have you used these 5 drugs correctly?
Time of Update: 2021-11-15
■Clinical studies of atorvastatin [1], compared with the dose of 10mg/d, 20mg/d of atorvastatin in the treatment of acute ischemic stroke patients can be more effective in lowering lipids and anti-inflammatory, thereby Stabilize atherosclerotic plaque, restore nervous system damage, improve quality of life, and have good safety .
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Why is dopamine so greedy?
Time of Update: 2021-11-15
Like humans, the dopamine neurons of fruit flies can provide a learning signal that helps them associate a specific smell with a specific result .
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"Frontiers in Neurology": Butylphthalide significantly improves the prognosis of patients with non-disabling ischemic cerebrovascular
Time of Update: 2021-11-15
Figure 2 NBP-compliant group and NBP-non-compliant group mRS score distribution subgroup analysis results show that after adjusting for age, gender, history of hypertension, body mass index, diabetes, dyslipidemia, smoking, drinking, admission to the NIHSS score, NBP in the NIHSS A score of 3-5 points has a better 90-day functional prognosis than the NIHSS score 0-2 group.
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Express treatment of Alzheimer's disease, stem cell therapy shows positive potential
Time of Update: 2021-11-15
▎Editor of WuXi AppTec's content team recently, GABAeron announced active preclinical research data obtained from cell therapy for Alzheimer's disease based on induced pluripotent stem cells (iPSC) .
In this study, scientists first successfully induced human iPSCs carrying the APOE3 gene to differentiate into GABAergic interneuron progenitor cells.
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Ticagrelor opens a new pattern of stroke dual-antibody therapy
Time of Update: 2021-11-15
Studies have confirmed that in patients with mild ischemic stroke or transient ischemic attack (TIA) carrying the loss-of-function allele of CYP2C19, compared with clopidogrel combined with aspirin treatment, ticagrelor combined with aspirin treatment takes 3 months The risk of recurrence of internal stroke was reduced by 23% .
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"Thunder" of neurology, how many have you stepped on?
Time of Update: 2021-11-15
Nadim lumbosacral plexus neuropathy reported that a 49-year-old female patient with cervical cancer developed progressive lower limb paralysis and pelvic pain 10 weeks after the completion of radiotherapy.
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How to deal with the "top killer" of national health?
Time of Update: 2021-11-15
The authoritative journal in the field of neurology, The Lancet Neurology, published an editorial for this, and pointed out that how to effectively reduce the risk factors related to stroke and dementia, thereby reducing the huge disease burden, is a huge challenge facing the current public health system, based on the "whole population" as a whole Prevention and control measures will help achieve joint prevention of stroke and dementia!
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Simpler nerve stimulation can restore the fine hand movements of paralyzed animals｜《Science·Translational Medicine》
Time of Update: 2021-11-15
Click on the blue text above and pay attention to our electrical stimulation system that can restore the fine hand movements and grip strength of paralyzed non-human primates.
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When you encounter "disorders of consciousness" in the emergency department, you can handle it like this
Time of Update: 2021-11-15
] Coma is a kind of inability to wake up Unconscious state, usually several days or weeks after acute brain injury; VS/UWS refers to patients who are awake but unconscious and can show unconscious reflexes; MCS shows non-reflective cortex-mediated behavior, and some MCS patients can be to a certain extent Obey commands, but cannot communicate with functions, and can change continuously with VS/UWS .
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Can the key protein of Alzheimer's disease be reduced with just one shot?
Time of Update: 2021-11-15
▲In mice treated by intravenous injection, the level of amyloid β in the brain was significantly lower than that in the control group (picture source: reference [2]; Credit: Hong Kong University of Science and Technology).
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"Contending" "glia-to-neuron" research needs to be cautious, lineage tracing is indispensable-denying that knocking out Ptbp1 can induce glial cells to transdifferentiate into neurons
Time of Update: 2021-11-15
In order to fully analyze the cell phenotype caused by knocking out Ptbp1 in Müller glia and Astrocytes, the authors used scRNA-Seq to analyze the retina, cortex, striatum and substantia nigra of wild-type, heterozygous and homozygous mice.
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Wang Xin's team from Zhongshan Hospital of Fudan University discovered the key mechanism of neuronal inclusion body disease
Time of Update: 2021-11-15
Recently, the team of Professor Wang Xin from the Department of Neurology, Zhongshan Hospital of Fudan University discovered that a previously unrecognized abnormal polyglycine protein (polyg) aggregation is the key mechanism of adult-type neuronal nuclear inclusion disease .
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What is the reason for the vertical diplopia in a 45-year-old man?
Time of Update: 2021-11-15
However, this patient may have two lesions, one involving the left MLF, leading to the left INO; the second lesion involving the trochlear nerve fibers originating from the trochlear nucleus on the right and crossing to the dorsal side of the left midbrain, causing SO on the left Paralysis (Figure 2A) .
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Professor Han Xiang: The key to the diagnosis and treatment of stroke in young people is...
Time of Update: 2021-11-15
In addition, Professor Han Xiang emphasized that the key to the treatment of stroke in young people is to clarify the underlying cause through diagnostic examinations and formulate corresponding secondary prevention strategies .
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The new mechanism of antihypertensive drug ARNI is here!
Time of Update: 2021-11-15
*Only for medical professionals to read for reference to prevent and control stroke, blood pressure is the last word, the new mechanism of blood pressure drug ARNI is here!
How will the launch of new antihypertensive drugs change clinical practice?
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Express overcomes the shortcomings of oral Parkinson's disease therapy, AbbVie's innovative infusion therapy reaches the phase 3 clinical endpoint
Time of Update: 2021-11-15
The test results showed that compared with oral levodopa/carbidopa (levodopa/carbidopa), subcutaneous infusion of ABBV-951 for 24 hours a day significantly improved the fluctuation of motor symptoms in patients with advanced Parkinson's disease .
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"Dad, don't hit me!" The sub-published "Nature" reveals how the "nature" of evading punishment and expecting rewards comes from
Time of Update: 2021-11-15
If you can’t recall it, a study published in "Nature Neuroscience" is enough to provide clues: The research team found a neural circuit that handles reward and punishment separately, and found that some neurons are "born" to be responsible for reward or punishment.
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Professor Dong Qiang: The key to the integration of medicine and prevention and prevention of stroke lies in...
Time of Update: 2021-11-15
For patients with non-cardiac stroke such as large atherosclerosis and small vessel disease, antiplatelet therapy can significantly reduce the risk of recurrence of serious cardiovascular events in patients .
