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High-yield team—Professor Gao Tianming once again reveals the molecular mechanism that regulates the disappearance of fearful memories
Time of Update: 2021-11-16
On October 25, 2021, Professor Gao Tianming's research team from the School of Basic Medical Sciences, Southern Medical University, from the perspective of the plasticity of the cortical PV-ergic neuron network, explained the key process of fear memory dissipation, and further found the molecule that regulates this process: neurogulin1 -ErbB4.
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ENCHANTED Study Announces: Effects of Alteplase Dosage and Antihypertensive Strength on Patients with Acute Ischemic Stroke WSC2021
Time of Update: 2021-11-15
Research Introduction The researchers explored the effects of low-dose alteplase intravenous administration and intensive blood pressure lowering on the outcome of AIS patients based on the vascular obstruction status/location of ENCHANTED subjects .
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Zhang Zhang's research group reports on the neural mechanism of exercise detoxification
Time of Update: 2021-11-15
Original link: https:// Jinan University's Zhang Li Research Group focused on the regulatory mechanism and intervention strategies of cortical synaptic plasticity, with special attention to the effects of aerobic exercise on affective cognitive impairment Improve effect .
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The flower of hope in the quagmire of despair: exploring the hotspot treatment strategies of rare disease spinal muscular atrophy (SMA)
Time of Update: 2021-11-15
" Small molecule splicing modifier Evrysdi (risdiplam): On August 7, 2020, the FDA approved Genentech’s Evrysdi for the treatment of spinal muscular atrophy in children aged 2 months and older .
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Huashan God’s experience talks: intravenous thrombolysis, don’t ignore these problems
Time of Update: 2021-11-15
The second key question is whether patients with acute ischemic stroke with large vessel occlusion can skip intravenous thrombolysis and directly undergo thrombectomy therapy .
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Nature Neuroscience: The loop mechanism of pain-induced anhedonia
Time of Update: 2021-11-15
After chronically activating inhibitory neurons in the RMTg brain area, rats consumed 5% sucrose solution, which is similar to the anhedonia state caused by pain .
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Cao Wenjie: Cerebrovascular interventional treatment, from preoperative evaluation to postoperative complications management points
Time of Update: 2021-11-15
. For patients with stenosis or occlusion of large intracranial vessels, foreign SAMMPRIS trials and VISSIST studies have failed to prove that intracranial artery stenosis is inferior to drug treatment by stent implantation.
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Bojian is deeply involved in the field of neurological disease treatment, and provides patients with better solutions!
Time of Update: 2021-11-15
The successive approvals of dimethyl fumarate and fampridine sustained-release tablets provide MS patients with a comprehensive treatment plan for short-term improvement of walking ability and long-term reduction of disease disability.
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Inventory: 2020~2021 Domestic and International Stroke Guidelines and Consensus Collection World Stroke Day
Time of Update: 2021-11-15
cn/guideline/20354 Article link: Under the epidemic prevention and control, the green channel management expert consensus on stroke diagnosis and treatment is released!
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Scientists reveal the molecular mechanism of obesity caused by long-term use of antidepressants
Time of Update: 2021-11-15
In general, this article found that fluoxetine causes weight gain through two different mechanisms: short-term fluoxetine administration causes Htr1a to autologously inhibit DRN serotonergic neurons, and reduces the activity of POMC neurons in the ARC brain area, and promotes food intake .
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The heavyweight Wang Yongjun leads the research to reach the top of the New England Journal of Medicine again, and the CHANCE-2 study guides new strategies for secondary stroke prevention
Time of Update: 2021-11-15
Professor Wang Yongjun said in an interview with the media that the team published the results of the CHANCE trial in NEJM in 2013, confirming that clopidogrel combined with aspirin treatment can be effective Reduce the risk of stroke recurrence in the Chinese population .
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For the drug treatment of essential tremor, please see the latest basic diagnosis and treatment guidelines!
Time of Update: 2021-11-15
Effectively reduce the amplitude of hand tremor by 40%~50%, so the improvement of primidone on tremor is better than that of phenobarbital and PEMA alone .
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Nat Commun's working memory representation of the visual cortex regulates the distraction effect
Time of Update: 2021-11-15
Written ︱ Zhou Zhou responsible editor ︱ Wang Sizhen’s advanced cognition relies on working memory (WM), which is the ability to maintain and perform operations on the internal representations of inf
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Immune CD4+ T cells are involved in the disease process of Lewy body dementia
Time of Update: 2021-11-15
Next, the author performed single-cell T cell receptor sequencing on the CSF of PD-DLB patients, and the results again showed that the expression of CD69 and CXCR4 were up-regulated, as well as the high expression of KLRB1 (killer lectin-like receptor subfamily B member 1) (Figure 2 E, F), marking the production of pro-inflammatory interleukin 17 (IL-17) .
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To guide the prevention of stroke recurrence in the Chinese population, and Wang Yongjun's team from Tiantan Hospital reached the top of NEJM
Time of Update: 2021-11-15
The results show that for patients with acute mild ischemic stroke or transient ischemic attack (TIA), if they carry the CYP2C19 inactivating allele, ticagrelor combined with aspirin is more effective than clopidogrel combined with aspirin in preventing stroke recurrence .
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Mol Psychiatry Gao Tianming's group reveals the local neural network mechanism of fear memory fading
Time of Update: 2021-11-15
Written by Chen Yihua, edited by Chen Yihua, Wang Sizhen Posttraumatic Stress Disorder (PTSD) is an individual suffering from a severe traumatic event that causes long-term and persistent physical an
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On the cover!
Time of Update: 2021-11-15
. On October 1, the Tsinghua University School of Medicine, Tsinghua-Peking University Joint Center for Life Sciences, and Tsinghua-IDG/McGovern Institute for Brain Science Guo Zengcai's group published an online publication entitled "High-speed and high-resolution whole brain sparse imaging in Cell Reports Methods "Sparse imaging and reconstruction tomography for high-speed high-resolution whole-brain imaging" research paper, the report proposes a SMART (sparse imaging and reconstruction tomography) system that uses a turntable confocal unit for high-resolution rapid imaging .
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The experience of Huashan God inside big coffee: these people are more prone to stroke
Time of Update: 2021-11-15
Ding Hongyan introduced that the main risk factors for stroke that cannot be prevented are age, gender, race, genetic history, etc.
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Significant progress in Circulation!
Time of Update: 2021-11-15
AAV9-based CRISPR/Cas9-AID (eTAM) and AAV9-sgRNA were injected into newborn Dmd E4* mice, and they were analyzed 2 or 12 months after treatment to assess exon skipping, The degree of dystrophin recovery and improvement of myocardial and skeletal muscle phenotype .
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Why does high blood pressure cause dementia?
Time of Update: 2021-11-15
"Through this clinical research database and biological sample library analysis, Professor Yu Jintai’s team discussed how many The impact of a variety of different blood pressure characteristics (including diagnosis of hypertension, systolic blood pressure, diastolic blood pressure, pulse pressure difference, mean arterial pressure, and blood pressure variability) on cognitive impairment and core pathological changes in AD, and found that the relationship between them is significant Age specificity .
