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JAMA Neuro: Don't underestimate the MRI report "white matter degeneration", it may be related to the progression of Parkinson's disease!
Time of Update: 2021-12-03
In summary, in this cohort study, higher levels of WMH and cerebrovascular disease pathological indexes in the elderly brain are associated with faster Parkinson's disease progression .
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Alz Res Therapy: Sodium oligomer GV-971, can improve dementia or be effective
Time of Update: 2021-12-03
1186/s13195-021-00795-7 A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer's dementia.
1186/s13195-021-00795-7 A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer's dementia.
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Neurology: The detection rate of cerebral microhemorrhage in middle-aged and elderly people is 7%
Time of Update: 2021-12-03
However, whether these risk factors are equally important for CMBs in different locations, and whether there are differences in the relationship between them and the lobes, deep and subtentorial CMBs, these questions still exist .
Prevalence and Risk Factors of Cerebral Microbleeds: Analysis From the UK Biobank .
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JAHA: Analysis of the curative effect of intravenous thrombolysis before mechanical thrombus removal in acute ischemic stroke
Time of Update: 2021-12-03
StrokeRecently, the heart blood vessels published on the prestigious journal JAHA the areas of disease research article, researchers conducted a meta-analysis, mechanical thrombectomy (dMT) with mechanical thrombectomy more direct intravenous thrombolysis joint bridging (bridging therapy [BT]) Efficacy in patients with acute ischemic stroke .
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Interpretation of schizophrenia cases
Time of Update: 2021-12-03
One and a half months after switching to lurasidone, the patient had no adverse drug reactions such as hand tremors, restlessness, and normal menstruation .
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Alz Res Therapy: Depression + cerebrovascular disease, greatly increasing the risk of dementia
Time of Update: 2021-12-03
Additive interaction of mid- to late-life depression and cerebrovascular disease on the risk of dementia: a nationwide population-based cohort study.
1186/s13195-021-00800-zAdditive interaction of mid- to late-life depression and cerebrovascular disease on the risk of dementia: a nationwide population-based cohort study.
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Why is the density difference of chest and abdominal hemorrhage or cerebral hemorrhage on CT so large?
Time of Update: 2021-12-01
Why is intra-abdominal bleeding not clotting?Due to the activities of the lungs, heart and diaphragm, the fibrin is removed and deposited on the surface of the viscera and parietal pleura to form rough gray-yellow fibrous membranes, so the blood in the pleural cavity generally does not coagulate .
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PNAS: Why does memory worsen after staying up late?
Time of Update: 2021-12-01
The greater activity among somatostatin-containing interneurons inhibits peripheral neurons, thereby inhibiting the overall hippocampal ribosomal S6 phosphorylation, as a gate to slow down its activationThen, the research team conducted further studies on mice, and they found that when this inhibitory gate mechanism is simulated in free-sleeping mice, it can disrupt hippocampal activity and memory consolidation .
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Baxter nerve impingement MR diagnosis which is easy to be misdiagnosed (with classic schematic diagram at a glance)
Time of Update: 2021-12-01
The enhanced scan occurs in the acute to subacute stage of denervation; in the case of Baxter nerve compression, according to the patient’s innervation anatomy, muscle edema will be selectively in the abductor digitorum (AbDM) occurs internally, and may also occur in the flexor digitorum brevis and quadratus plantar muscle; obvious muscle atrophy and fatification can be seen in the chronic phase .
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Science︱ proved in the human body for the first time: a variety of neurodegenerative diseases can affect the neurogenesis of the hippocampal dentate gyrus
Time of Update: 2021-11-16
Authors︱Editor in charge by Wang Zerui︱Wang Sizhen Adult neurogenesis mainly occurs in specific areas of the adult mammalian brain, such as the hippocampal dentate gyrus and the subventricular zone/o
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Research progress on the neural mechanism of striatum regulating motor function
Time of Update: 2021-11-16
The study found that the direct and indirect pathways of striatal neurons have different regulatory effects on movement on the second and hundred millisecond time scales, providing new clues for understanding the mechanism of basal ganglia regulating movement .
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The prefrontal neurons of monkeys and bats promote group communication｜Science Weekly Selection
Time of Update: 2021-11-16
In these two studies, Raymundo Báez-Mendoza and colleagues and Maimon Rose and colleagues evaluated the role of the prefrontal cortex and the frontal cortex in the social communication of rhesus monkeys and Egyptian fruit bats, respectively .
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Neuron Jiang Youxing's group reveals the working mechanism of CNGA1/B1 ion channels in human rod cells
Time of Update: 2021-11-16
Responsible Editor | Xi The mammalian cyclic nucleotide-gated channels (CNG channels) play an important role in the signal transduction process of the visual and olfactory sensory systems . After
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New discovery: fat cells play a central role in cognitive decline and neurodegenerative diseases
Time of Update: 2021-11-16
However, the overexpression of adipocyte-specific NaKtide induced by doxycycline significantly slowed the increase of inflammatory factors, body weight and blood sugar in mice fed Western diet .
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Neuron: Unlike you think, scientists reveal the neural circuits that regulate body temperature behavior
Time of Update: 2021-11-16
The optical fiber calcium imaging system found that the LH-Vgat neurons were activated in large numbers during the nasal contact behavior of mice, and the activity decreased rapidly after being heated by infrared light .
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Sci Adv's Lu Hui team found that exercise training improves the motor coordination and other functions of Mecp2 mutant mice
Time of Update: 2021-11-16
Next, the author studied whether exercise training has effects other than affecting motor skills, such as improving anxiety .
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Neuron︱New Discovery!
Time of Update: 2021-11-16
, Neuron 2021) In order to evaluate whether all past experiences have the same playback priority, the researchers tested those The playback rate of the arm that was never used as the target position during the current behavior.
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Sub-Journal of "Nature": Subversion of Cognition!
Time of Update: 2021-11-16
The cognitive impairment caused by AD is characterized by a decline in spatial positioning ability, but the disease-causing gene APOE ε4 of AD can enhance the ability of visual working memory, and this effect continues into old age .
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Mol Psychiatry︱The new discovery of a biomarker for depression-mitochondrial protein in exosomes
Time of Update: 2021-11-16
The article compares the difference in functional mitochondrial protein of neuron-derived extracellular vesicles between MDD patients before and after treatment with a specific serotonin reuptake inhibitor (SSRI) and healthy controls of the corresponding age and gender.
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Sci Signaling｜Jianfeng Liu's team reveals that GABAB receptors activate G13 protein pathways to promote neuroprotection
Time of Update: 2021-11-16
Professor Liu Jianfeng's research group has been engaged in the study of the structure and function of GABAB receptors for a long time, and has conducted systematic and in-depth research on the structure and activation of the GABAB receptor and the binding mode, function and signal pathway of G protein .
