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Nat Commun: Scientists have discovered a new molecular mechanism of reduced blood vessels in the brains of patients with Alzheimer's disease
Time of Update: 2021-06-08
()In this study, the researchers confirmed that NPA (non-productive angiogenesis) and microglia play a key role in the process of local vascular breakdown, and also emphasized that the body of Alzheimer’s disease patients Premature loss of vascular tissue functionOriginal source:Original source:Alvarez-Vergara, MI, Rosales-Nieves, AE, March-Diaz, R.
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The first oral medicine for spinal muscular atrophy (SMA)! Roche's Evrysdi treatment has continued to improve motor function and survival rate for 2 years. It has been under review in China!
Time of Update: 2021-06-08
Data from two key clinical trials confirm that Evrysdi is effective for infants, children, and adults aged 2 months and older, and is used in SMA patients of different ages and disease severity (including type 1, type 2, and type 3).
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Science: The new miniaturized high-density probe Neuropixels 2.0 can stably record the brain for a long time
Time of Update: 2021-06-08
News April 19, 2021//---The electrode array based on complementary metal oxide semiconductor silicon manufacturing technology, such as Neuropixels probes, has been able to record thousands of neurons in the living brain.
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PNAS: how regulatory T cells regulate the autoimmune response of the central nervous system
Time of Update: 2021-06-08
The results showed that although there was no significant difference in the number of Treg cells in the CNS region of icKO and wild-type mice, the expression levels of CTLA-4 and Blimp-1 of Treg cells in mutant mice were significantly down-regulated, and their activation levels were also affected.
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JAMA Neuro: After the cerebral hemorrhage, recovery is over?
Time of Update: 2021-06-08
This study found that cerebral hemorrhage is associated with an increased risk of ischemic stroke and myocardial infarction.
This study found that cerebral hemorrhage is associated with an increased risk of ischemic stroke and myocardial infarction.
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Highlights of Science Journal on April 9, 2021
Time of Update: 2021-06-08
abh3187 Science: reveals that the protein QSER1 protects DNA methylation valleys from new methylation doi:10.
The relevant research results were published in the Science Journal on April 9, 2021, with the title of the paper "Mechanism and dynamics of fatty acid photodecarboxylase".
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Progress of HIV research highlights in March 2021
Time of Update: 2021-06-08
1009339 In a new preclinical study, from the US Military HIV Research Program (MHRP) research The researchers found that a combination of experimental therapies using a TLR7 agonist and two broadly neutralizing antibodies can delay the viral rebound of SIV-infected rhesus monkeys after the interruption of antiretroviral therapy (ART).
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Research finds that miR-218-2 regulates hippocampal cognitive function and its mechanism
Time of Update: 2021-06-08
Rescue the synaptic function and cognitive deficits of miR-218-2 gene knockout mice.
Therefore, the authors concluded that complement factor C3 is the main target gene for miR-218 to regulate synaptic function.
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Research and propose a convolutional neural network for multi-scale detection of micro-expression fragments in long videos
Time of Update: 2021-06-08
Video video video videoInspired by flat face detection technology, Huang Changbing's research group at the Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences tried to extend the corresponding technology to three-dimensional space-time facial micro-expression detection, and proposed a multi-scale convolutional neural network ( CNN): MESNet.
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Research and analysis of the relationship between HIV infection and cognitive impairment in the elderly
Time of Update: 2021-06-08
Recently, the Department of Bioinformatics and Biostatistics, School of Life Science and Technology , Shanghai Jiaotong University, and the team from the Shanghai Jiao Tong University -Yale Joint Center for Biostatistics and Data Science published a titled Association of HIV-infection in "Ageing Research Reviews" (IF: 10.
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Science: New research reveals that elevated striatal dopamine can cause hallucinations
Time of Update: 2021-06-08
The relevant research results were published in the Science Journal on April 2, 2021, with the title of the paper "Striatal dopamine mediates hallucination-like perception in mice".
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[6.9-Day Neurology Live Preview] Diagnosis and Differential Diagnosis of Parkinson's Disease
Time of Update: 2021-06-08
Help you to fully understand the symptoms and course characteristics of Parkinson's disease, make a more accurate diagnosis, achieve precise management of chronic diseases , and help you specify more individualized treatmentsPrecise management Therefore, Metz Medical Special invites the teacher of Ruijin Hospital (Zhang Jing) Affiliated to Shanghai Jiaotong University School of Medicine to give online lectures to share clinical experience with you.
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Nat Commun: Adenosine integrates light and sleep signals to regulate the circadian rhythm in mice
Time of Update: 2021-06-08
Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice.
Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice.
1038/s41467-021-22179-z Original source: Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice.
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Scientists found that alcohol metabolite acetic acid causes abnormal behavior
Time of Update: 2021-06-08
Metabolic diseaseRecently, a research team from the National Institutes of Health found that the balance and movement coordination disorders caused by drinking are mediated by the metabolite of ethanol, acetic acid, rather than the traditional concept of ethanol.
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Men are selfish, picky... or because of too much testosterone?
Time of Update: 2021-06-08
Recently, in a study published in the Proceedings of the National Academy of Sciences (PNAS), a research team led by Shenzhen University revealed through experiments conducted in male volunteers that high levels of testosterone would weaken generosity and determined The neurological mechanism that leads to this behavior.
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Sleep: Treating obstructive sleep apnea may reduce the risk of dementia
Time of Update: 2021-06-08
In this study, researchers from the Sleep Disorder Research Center of the Medical College of Michigan analyzed the Medicare health insurance data of 53,321 people over 65 who were diagnosed with OSA, and explored the positive airway pressure (PAP) treatment and the next 3 years.
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Alzheimers Dementia: Pathological protein levels in cerebrospinal fluid, which can reflect the density of cortical neurons
Time of Update: 2021-06-08
The important significance of this study is that it is found that NDI is a particularly sensitive marker of early cortical changes that occur before severe atrophy or the development of cognitive impairment.
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New medicine for refractory epilepsy!
Time of Update: 2021-06-08
In 2 adequate and well-controlled clinical studies, Ontozry significantly reduced the frequency of focal seizures compared with placebo, and up to 20% of patients achieved zero seizures during the maintenance period.
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The first idiopathic narcolepsy (IH) drug!
Time of Update: 2021-06-08
In July 2020, Xywav was approved by the US FDA for the treatment of cataplexy or excessive daytime sleepiness (EDS) in narcolepsy (narcolepsy) patients 7 years and older.
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JAMA Sub-Journal: Be alert!
Time of Update: 2021-06-08
In 2016, a case-control study published in the journal Neurology showed that in young stroke patients with unknown etiology , there is a statistically significant correlation between the carotid artery network (CW) and ischemic stroke.
