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Highlights of Science Journals Must-See Research in May 2021
Time of Update: 2021-06-08
The relevant research results were published in the Science Journal on May 14, 2021, with the title of the paper "A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements".
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Nat Aging: Large-scale plasma proteome analysis to identify risk proteins related to dementia
Time of Update: 2021-06-08
Existing studies have shown that the blood levels of several biologically-related molecules are related to the risk of Alzheimer’s disease and wider dementia, but at present, we still lack information about all changes in the plasma proteome in the previous years of dementia.
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The US FDA approves Qelbre (Viloxazine): the first non-stimulant therapy for attention deficit hyperactivity disorder (ADHD) in 10 years!
Time of Update: 2021-06-08
"() Original source: Supernus Announces FDA Approval of Qelbree (SPN-812) for the Treatment of ADHD April 06, 2021 // --Supernus Pharma is a professional biopharmaceutical company focusing on the development and commercialization of drugs for the treatment of central nervous system (CNS) diseases.
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Research on the sustained-release NT-3 three-dimensional microenvironment supporting the self-organized development of neural stem cells into neural network tissues with repair purposes was published in Bioactive Materials
Time of Update: 2021-06-08
During the development of the embryonic spinal cord, the mechanism of neurogenesis involves the interaction between specific ligands and receptors, which helps guide the construction of tissue-engineered neural networks for transplantation and repair of the structure and function of the full-transected spinal cord .
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The study realizes quantitative calculation of individual development and aging differences through brain image analysis
Time of Update: 2021-06-08
Genetic In view of the above-mentioned individual different social phenomena in the process of human brain aging, can this individual difference be quantitatively described based on brain imaging data?
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PNAS: Key cell groups mediate the persistent autoimmune response of the central nervous system
Time of Update: 2021-06-08
(Figure 2, CD11c Cre +/- ITGA4fl/fl mouse EAE disease progression is significantly improved compared to wild type ) On this basis, the author compared this finding with clinical patient information.
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JAHA: The relationship between daytime naps and heart failure in the elderly
Time of Update: 2021-06-08
Recently, the heart blood vessels published a research article on the disease areas authoritative magazine JAHA, the researchers tried to investigate the association between the risk of developing HF during daytime naps and objective assessment of the follow-up.
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Alzheimers Dementia: Primary progressive aphasia combined with pathology, with more pronounced neurological degeneration
Time of Update: 2021-06-08
It is found that compared with the neuropathological manifestations of non-AD, patients with non-semantic PPA (combined with AD pathology) seem to have more significant functional decline and destroy more aspects of life activities.
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JAMA Sub-Journal: Be alert!
Time of Update: 2021-06-08
In 2016, a case-control study published in the journal Neurology showed that in young stroke patients with unknown etiology , there is a statistically significant correlation between the carotid artery network (CW) and ischemic stroke.
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JAMA Sub-Journal: Oh my god!
Time of Update: 2021-06-08
In 2019, Professor Kan Haidong of the School of Public Health of Fudan University published a study in the world's top journal, the New England Journal of Medicine (NEJM), which showed that slight air pollution is also associated with increased mortality.
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Science: reveals that PCDH19-Ncad mismatch causes female-specific PCDH19 disorders
Time of Update: 2021-06-08
The relevant research results were published in the Science Journal on April 16, 2021, with the title of the paper "Female-specific synaptic dysfunction and cognitive impairment in a mouse model of PCDH19 disorder".
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JAMA: A small "button" can better identify atrial fibrillation than traditional ECG!
Time of Update: 2021-06-08
There are 8 pre-specified secondary results, including event analysis time for new atrial fibrillation, recurrent ischemic stroke, intracerebral hemorrhage, death, and equipment-related serious adverse events within 12 months.
6128Effect of Implantable vs Prolonged External Electrocardiographic Monitoring on Atrial Fibrillation Detection in Patients With Ischemic Stroke The PER DIEM Randomized Clinical Trial.
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Focus on drug targets: progress in drug development targeting GABA receptors
Time of Update: 2021-06-06
GABA activates the chloride ion channel through the GABAA receptor on the neuron cell membrane, leading to the influx of chloride ion in the cell, producing inhibitory postsynaptic potentials to play a role, and inhibiting neuronal excitement.
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Targeting PAC1R: precise removal of toxic tau protein to improve the cognitive ability of mice
Time of Update: 2021-06-06
In a new study published in Science Translational Medicine on May 26, the Columbia University Irvine Medical Center Researchers have discovered a more precise way to remove the toxic tau protein.
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Harvard scientists revealed how the key protein of Alzheimer's disease is formed and is expected to develop new treatments...
Time of Update: 2021-06-06
Mystery: How does amyloid beta (Aβ), a key protein that affects Alzheimer's disease, form in the axons of brain neurons and structures related to neural connections.
Retrieved May 19, 2021, from https:// mystery-of-how-amyloid-beta-a-key-player-in-Alzheimers-form-%20in-brain-nerve-cells
Retrieved May 19, 2021, from https:// mystery-of-how-amyloid-beta-a-key-player-in-Alzheimers-form-%20in-brain-nerve-cells
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Innovative DMD therapy reaches the key clinical trial endpoint and is expected to submit a new drug early next year...
Time of Update: 2021-06-06
Today, Santhera Pharmaceuticals and ReveraGen BioPharma jointly announced that the innovative therapy vamorolone has reached the primary endpoint and multiple key secondary endpoints in a pivotal Phase 2b clinical trial for the treatment of patients with Duchenne muscular dystrophy (DMD).
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This virus has been lurking in the human genome for thousands of years, and it is the first to prove that it affects the brain...
Time of Update: 2021-06-06
▲Schematic diagram of the mechanism of the study: activation of HERV-K (HML-2) leads to excessive activation of genes such as NTRK3, impairing the differentiation of cerebral cortex neurons and cortical development (picture source: reference [1])
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15 approvals to transfer up to 20 million
Time of Update: 2021-06-06
signed the "Agreement on the Change of the Main Body of the Drug Marketing License Holder" on May 10, 2021, and Lifang Pharmaceutical was transferred for RMB 38 million.
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The 14-year-old boy has sudden weakness and headache. What are the reasons?
Time of Update: 2021-06-05
The differential diagnosis of acute weakness and weakened reflexes includes trauma (such as spinal shock, acute nerve injury), side infections [such as acute inflammatory demyelinating multiple radiculopathy (AIDP)] and direct infection [such as polio virus, West Nile virus, acute flaccid myelitis (AFM)].
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Sci Adv | Wu Qi's team reports a novel dopamine loop that reduces obesity and weight by enhancing satiety
Time of Update: 2021-06-05
Editor | Enzyme Beauty Just like every good story has a beginning, a climax, and an end, the animal instinctive behavior of foraging consists of a trilogy that includes the beginning, the continuatio
