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Nat Commun: Intestinal health or body emotions are related to each other!
Time of Update: 2021-03-23
Researcher Wray said that in order to identify why certain people suffer from ulcers, we analyzed the health data of 456,327 people in the UK biobank and identified 8 genetic variants that increase the risk of peptic ulcer disease; among them, Six genetic variations are closely related to why certain people are more susceptible to Helicobacter pylori infection.
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Eraser of memory?
Time of Update: 2021-03-23
Recently, the team of Professor Zhong Yi from the School of Life Sciences of Tsinghua University published a new study titled "Clock neurons gate memory extinction in Drosophila" in the Cell Press journal Current Biology.
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Nature Sub-Journal | Significant progress!
Time of Update: 2021-03-23
In terms of mechanism, this study showed that ATF4 interacts with transient receptor potential cation channel subfamily M member 3 (TRPM3) and mediates the membrane transport of TRPM3 by DRG neurons in response to heat.
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The New England Journal of Medicine publishes the results of Roche's oral drug Risdiplam for the treatment of SMA
Time of Update: 2021-03-23
On February 25, 2021, the "New England Journal of Medicine" published the data results of the first part of the FIREFISH study of Risdiplam in children with type 1 SMA, and this article is hereby collated and reported.
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IJMS: New drugs can effectively reduce neuroinflammation
Time of Update: 2021-03-23
In this work, we tested that oxymethylene ketone can inhibit the synthesis of hyaluronic acid and measure its effect on the inflammatory response of astrocytes," Dmitry Chistyakov, senior researcher at RUDN University Collective Use Center (Research and Education Center) Said the doctor.
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FDA approves the first exon 45 skipping DMD targeted drug Casimersen
Time of Update: 2021-03-23
On February 15, the FDA approved the Casimersen (trade name: Ammondys 45) developed by Sarepta Therapeutics for the treatment of patients with Duchenne progressive muscular dystrophy (DMD) with a gene mutation exon 45 skipping type.
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NCB | Lin's team revealed the principle of "warm babies" - brown fat fever - under nerve stimulation
Time of Update: 2021-03-23
Lin Shengcai’s team just published their work on Nature Cell Biology and discovered that AIDA can be directly plugged into the heat-generating machine UCP1, which inherits the signal from sympathetic nerves to brown fat’s heat-generating pathways that people have long been expecting to reveal.
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"Lancet" Oxford large-scale study: these small stroke "atypical" symptoms should be paid attention to!
Time of Update: 2021-03-23
The latest issue of The Lancet published an analysis from a research team at the University of Oxford, showing that TIA patients with atypical symptoms and TIA patients with typical symptoms have similar follow-up stroke risks and long-term risks.
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Astrocytes derived from patients with bipolar disorder affect neuronal activity
Time of Update: 2021-03-23
com/tags/%E5%B9%B2%E7%BB%86%E8%83%9E/">stem cell "Our findings indicate that IL-6 may cause deficiencies related to bipolar disorder, which opens up new avenues for clinical intervention.
com/tags/%E5%B9%B2%E7%BB%86%E8%83%9E/">stem cell The response of patient astrocytes to pro-inflammatory cytokines shows a unique transcription pattern characterized by high expression of IL-6 gene.
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Research and develop a new paradigm of "dynamic disturbance" that manipulates the working memory of the human brain and establish a neural network dynamic model
Time of Update: 2021-03-23
com)Working memory refers to the short-term storage and manipulation of external information, which is the core function of brain cognition.
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The first movement disorder named by a Chinese scholar, led by a doctor from the affiliated Ruijin Hospital
Time of Update: 2021-03-23
com)"Can the scar after surgery dance?" Recently, Wu Yiwen, chief physician of the Department of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, and Professor Wan Xinhua, Department of Neurology, Peking Union Medical College Hospital, jointly named a new movement disorder syndrome—— "Scar Dancing Syndrome" (Scar Dancing Syndrome), this is the first movement disorder named by a Chinese scholar.
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Intracranial "full of stars", the cause is...
Time of Update: 2021-03-23
Figure 8: The axial position of the enhanced MRI scan of the head shows diffuse nodules and ring-shaped abnormal enhancement signal shadows of different sizes in the frontal, parietal, occipital, cerebellum, and basal ganglia areas, and the "off-center target sign" can be seen.
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Lancet: Oxford University research found that "atypical minor strokes" are so harmful to you that you can't think of them
Time of Update: 2021-03-23
Compared with typical TIA episodes, patients with atypical TIA episodes have a higher risk of early and long-term stroke.
In addition, the 10-year risk of major vascular events in patients with typical and atypical TIA was similar (27.
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Deng Hongkui's team and others realized the chemical reprogramming of astrocytes into neurons in vivo
Time of Update: 2021-03-23
In this study, the research team further developed a new combination of small molecules on the basis of the previous ones: DBcAMP, Forskolin, ISX9, CHIR99021, I-BET151 and Y-27632 (DFICBY) can achieve in vivo chemistry more efficiently Reprogramming can reprogram the astrocytes in the adult mouse brain into neurons with synaptic connectivity, called chemically induced neurons (CiNs).
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Intravenous thrombolysis for acute ischemic stroke, what does the 2021 ESO guide say?
Time of Update: 2021-03-23
5-9 hours (the time of onset is clear) and CT or MRI core/perfusion does not match*, and not suitable Or for patients who do not plan to mechanically remove the thrombus, intravenous thrombolysis with alteplase is recommended (strong recommendation, low-quality evidence).
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JAD: Exercise can give priority to alleviating memory loss in Alzheimer's patients
Time of Update: 2021-03-23
"Our main findings indicate that compared with the natural course of Alzheimer’s dementia, a six-month aerobic exercise intervention can significantly reduce cognitive decline.
3233/JAD-201100"Our main findings indicate that compared with the natural course of Alzheimer’s dementia, a six-month aerobic exercise intervention can significantly reduce cognitive decline.
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New evidence that butylphthalide delays cognitive function in AD patients: a multicenter, prospective cohort study
Time of Update: 2021-03-23
This study used the Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-cog), the Clinical Impression Change Scale (CIBIC-plus), the Alzheimer’s Disease Collaborative Research Daily Ability Scale (ADCS-ADL) and The neuropsychiatric questionnaire (NPI) assessed the overall efficacy of NBP, followed up for 48 weeks.
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Explore the molecular mechanism of memory function formation
Time of Update: 2021-03-22
Source: SCIEPRO/GETTY In January 2020, Wang Xiaoqun, a researcher at the Institute of Biophysics, Chinese Academy of Sciences, and Wu Qian, a professor at Beijing Normal University, and others published a paper in the journal Nature [1], revealing the dynamic development process of the human hippocampus.
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The effects of social isolation on the human neural circuits during the | Cell Press Paper Express
Time of Update: 2021-03-22
The neural composition of social balance Social balance is a personal ability to detect the quantity and quality of social contact, compare it with the established set point of the command center, and adjust the energy spent seeking social contact through the effect system (Figure 1 and Table 1) (Matthews and Tye, 2019).
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A 32-year-old man suffered a stroke and was admitted to the hospital. He did not get better after 1 week of treatment. The reason was...
Time of Update: 2021-03-22
Combined with the patient's clinical manifestations, imaging examinations, cerebrospinal fluid and cardiac ultrasound examinations, the patient's final diagnosis was: left atrial myxoma caused multiple cerebral embolism.
Cerebral embolism caused by atrial myxoma is the most common form of thrombus shedding.
