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News from March 1, 2021 //--- Biologists at RUDN University confirmed that a drug called oxymethenone can inhibit astrocytes (an important glial cell of the central nervous system).
The inflammatory response can therefore be used to develop drugs for Alzheimer's disease and other neurodegenerative diseases.
The research results were published in the International Journal of Molecular Science.
The inflammatory response can therefore be used to develop drugs for Alzheimer's disease and other neurodegenerative diseases.
The research results were published in the International Journal of Molecular Science.
(Image source:style="text-align: justify;">All pathological processes of the nervous system, such as neurodegenerative diseases, injury or poisoning, are related to inflammation.
This is due to the response of many helper cells, including astrocytes that support neural activity in the brain.
When inflamed, astrocytes produce many anti-inflammatory molecules (cytokines, interleukins and lipoproteins), which aggravate and accelerate the inflammatory process.
Neuroinflammation almost always leads to the death of nerve cells.
This is due to the response of many helper cells, including astrocytes that support neural activity in the brain.
When inflamed, astrocytes produce many anti-inflammatory molecules (cytokines, interleukins and lipoproteins), which aggravate and accelerate the inflammatory process.
Neuroinflammation almost always leads to the death of nerve cells.
A team of biologists at RUDN University and colleagues at Lomonosov Moscow State University confirmed that the intensity of inflammation can be reduced by limiting the number of anti-inflammatory molecules produced by astrocytes.
For this, they recommend the use of oxymethenone, which is a drug currently used to treat cramps.
For this, they recommend the use of oxymethenone, which is a drug currently used to treat cramps.
"Astrocytes can synthesize hyaluronic acid, which is one of the main components of the extracellular matrix of the brain.
Our research shows that adding hyaluronic acid to astrocytes affects the production of major anti-inflammatory molecules.
In this work, we tested that oxymethylene ketone can inhibit the synthesis of hyaluronic acid and measure its effect on the inflammatory response of astrocytes," Dmitry Chistyakov, senior researcher at RUDN University Collective Use Center (Research and Education Center) Said the doctor.
Our research shows that adding hyaluronic acid to astrocytes affects the production of major anti-inflammatory molecules.
In this work, we tested that oxymethylene ketone can inhibit the synthesis of hyaluronic acid and measure its effect on the inflammatory response of astrocytes," Dmitry Chistyakov, senior researcher at RUDN University Collective Use Center (Research and Education Center) Said the doctor.
The team studied the effects of oxymethylene ketone on astrocytes in rat brain cell cultures.
Cell culture samples were first activated with liposugar to activate receptors that activate inflammation, and then treated with oxymethenone.
To evaluate the effectiveness of the drug, the research team extracted RNA from astrocytes and measured the activity of genes that regulate the production of anti-inflammatory molecules.
The levels of hyaluronic acid and cytokines are measured in the cell supernatant.
Use high performance liquid chromatography and tandem mass spectrometry to evaluate the changes in signal lipid (lipoprotein) synthesis.
Cell culture samples were first activated with liposugar to activate receptors that activate inflammation, and then treated with oxymethenone.
To evaluate the effectiveness of the drug, the research team extracted RNA from astrocytes and measured the activity of genes that regulate the production of anti-inflammatory molecules.
The levels of hyaluronic acid and cytokines are measured in the cell supernatant.
Use high performance liquid chromatography and tandem mass spectrometry to evaluate the changes in signal lipid (lipoprotein) synthesis.
Facts have proved that oxymethylene ketone can inhibit the production of anti-inflammatory molecules: tumor necrosis factor α, interleukins IL-6 and IL-1β, and lipoproteins.
At the same time, it increases the development of IL-10 and helps prevent inflammation.
After measuring the level of hyaluronic acid, the research team confirmed that astrocytes actively produce this substance in response to liposugar.
However, when the cell culture at the initial stage of the immune response was treated with oxymethenone, the level of hyaluronic acid decreased.
At the same time, oxymethylene ketone does not have the same effect on cells that are not inflamed after contact with liposugar.
In these cultures, astrocytes continue to produce hyaluronic acid on a regular basis.
(Bioon.
com)
At the same time, it increases the development of IL-10 and helps prevent inflammation.
After measuring the level of hyaluronic acid, the research team confirmed that astrocytes actively produce this substance in response to liposugar.
However, when the cell culture at the initial stage of the immune response was treated with oxymethenone, the level of hyaluronic acid decreased.
At the same time, oxymethylene ketone does not have the same effect on cells that are not inflamed after contact with liposugar.
In these cultures, astrocytes continue to produce hyaluronic acid on a regular basis.
(Bioon.
com)
Source of information: com/news/2021-02-biologists-substance-suppress-neuroinflammation.
html">Biologists suggest a new substance to suppress neuroinflammation
html">Biologists suggest a new substance to suppress neuroinflammation
Original source: Dmitry V.
Chistyakov et al, Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone as an Anti-Inflammatory Modulator of LPS-Mediated Astrocyte Responses, International Journal of Molecular Sciences (2020).
DOI: 10.
3390/ijms21218203
Chistyakov et al, Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone as an Anti-Inflammatory Modulator of LPS-Mediated Astrocyte Responses, International Journal of Molecular Sciences (2020).
DOI: 10.
3390/ijms21218203
A team of biologists at RUDN University and colleagues at Lomonosov Moscow State University confirmed that the intensity of inflammation can be reduced by limiting the number of anti-inflammatory molecules produced by astrocytes.
For this, they recommend the use of oxymethenone, which is a drug currently used to treat cramps.
For this, they recommend the use of oxymethenone, which is a drug currently used to treat cramps.
"Astrocytes can synthesize hyaluronic acid, which is one of the main components of the extracellular matrix of the brain.
Our research shows that adding hyaluronic acid to astrocytes affects the production of major anti-inflammatory molecules.
In this work, we tested that oxymethylene ketone can inhibit the synthesis of hyaluronic acid and measure its effect on the inflammatory response of astrocytes," Dmitry Chistyakov, senior researcher at RUDN University Collective Use Center (Research and Education Center) Said the doctor.
Our research shows that adding hyaluronic acid to astrocytes affects the production of major anti-inflammatory molecules.
In this work, we tested that oxymethylene ketone can inhibit the synthesis of hyaluronic acid and measure its effect on the inflammatory response of astrocytes," Dmitry Chistyakov, senior researcher at RUDN University Collective Use Center (Research and Education Center) Said the doctor.
The team studied the effects of oxymethylene ketone on astrocytes in rat brain cell cultures.
Cell culture samples were first activated with liposugar to activate receptors that activate inflammation, and then treated with oxymethenone.
To evaluate the effectiveness of the drug, the research team extracted RNA from astrocytes and measured the activity of genes that regulate the production of anti-inflammatory molecules.
The levels of hyaluronic acid and cytokines are measured in the cell supernatant.
Use high performance liquid chromatography and tandem mass spectrometry to evaluate the changes in signal lipid (lipoprotein) synthesis.
Cell culture samples were first activated with liposugar to activate receptors that activate inflammation, and then treated with oxymethenone.
To evaluate the effectiveness of the drug, the research team extracted RNA from astrocytes and measured the activity of genes that regulate the production of anti-inflammatory molecules.
The levels of hyaluronic acid and cytokines are measured in the cell supernatant.
Use high performance liquid chromatography and tandem mass spectrometry to evaluate the changes in signal lipid (lipoprotein) synthesis.
Facts have proved that oxymethylene ketone can inhibit the production of anti-inflammatory molecules: tumor necrosis factor α, interleukins IL-6 and IL-1β, and lipoproteins.
At the same time, it increases the development of IL-10 and helps prevent inflammation.
After measuring the level of hyaluronic acid, the research team confirmed that astrocytes actively produce this substance in response to liposugar.
However, when the cell culture at the initial stage of the immune response was treated with oxymethenone, the level of hyaluronic acid decreased.
At the same time, oxymethylene ketone does not have the same effect on cells that are not inflamed after contact with liposugar.
In these cultures, astrocytes continue to produce hyaluronic acid on a regular basis.
(Bioon.
com)
At the same time, it increases the development of IL-10 and helps prevent inflammation.
After measuring the level of hyaluronic acid, the research team confirmed that astrocytes actively produce this substance in response to liposugar.
However, when the cell culture at the initial stage of the immune response was treated with oxymethenone, the level of hyaluronic acid decreased.
At the same time, oxymethylene ketone does not have the same effect on cells that are not inflamed after contact with liposugar.
In these cultures, astrocytes continue to produce hyaluronic acid on a regular basis.
(Bioon.
com)
Source of information: com/news/2021-02-biologists-substance-suppress-neuroinflammation.
html">Biologists suggest a new substance to suppress neuroinflammation
html">Biologists suggest a new substance to suppress neuroinflammation
Original source: Dmitry V.
Chistyakov et al, Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone as an Anti-Inflammatory Modulator of LPS-Mediated Astrocyte Responses, International Journal of Molecular Sciences (2020).
DOI: 10.
3390/ijms21218203
Chistyakov et al, Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone as an Anti-Inflammatory Modulator of LPS-Mediated Astrocyte Responses, International Journal of Molecular Sciences (2020).
DOI: 10.
3390/ijms21218203
"Astrocytes can synthesize hyaluronic acid, which is one of the main components of the extracellular matrix of the brain.
Our research shows that adding hyaluronic acid to astrocytes affects the production of major anti-inflammatory molecules.
In this work, we tested that oxymethylene ketone can inhibit the synthesis of hyaluronic acid and measure its effect on the inflammatory response of astrocytes," Dmitry Chistyakov, senior researcher at RUDN University Collective Use Center (Research and Education Center) Said the doctor.
Our research shows that adding hyaluronic acid to astrocytes affects the production of major anti-inflammatory molecules.
In this work, we tested that oxymethylene ketone can inhibit the synthesis of hyaluronic acid and measure its effect on the inflammatory response of astrocytes," Dmitry Chistyakov, senior researcher at RUDN University Collective Use Center (Research and Education Center) Said the doctor.
The team studied the effects of oxymethylene ketone on astrocytes in rat brain cell cultures.
Cell culture samples were first activated with liposugar to activate receptors that activate inflammation, and then treated with oxymethenone.
To evaluate the effectiveness of the drug, the research team extracted RNA from astrocytes and measured the activity of genes that regulate the production of anti-inflammatory molecules.
The levels of hyaluronic acid and cytokines are measured in the cell supernatant.
Use high performance liquid chromatography and tandem mass spectrometry to evaluate the changes in signal lipid (lipoprotein) synthesis.
Cell culture samples were first activated with liposugar to activate receptors that activate inflammation, and then treated with oxymethenone.
To evaluate the effectiveness of the drug, the research team extracted RNA from astrocytes and measured the activity of genes that regulate the production of anti-inflammatory molecules.
The levels of hyaluronic acid and cytokines are measured in the cell supernatant.
Use high performance liquid chromatography and tandem mass spectrometry to evaluate the changes in signal lipid (lipoprotein) synthesis.
Facts have proved that oxymethylene ketone can inhibit the production of anti-inflammatory molecules: tumor necrosis factor α, interleukins IL-6 and IL-1β, and lipoproteins.
At the same time, it increases the development of IL-10 and helps prevent inflammation.
After measuring the level of hyaluronic acid, the research team confirmed that astrocytes actively produce this substance in response to liposugar.
However, when the cell culture at the initial stage of the immune response was treated with oxymethenone, the level of hyaluronic acid decreased.
At the same time, oxymethylene ketone does not have the same effect on cells that are not inflamed after contact with liposugar.
In these cultures, astrocytes continue to produce hyaluronic acid on a regular basis.
(Bioon.
com)
At the same time, it increases the development of IL-10 and helps prevent inflammation.
After measuring the level of hyaluronic acid, the research team confirmed that astrocytes actively produce this substance in response to liposugar.
However, when the cell culture at the initial stage of the immune response was treated with oxymethenone, the level of hyaluronic acid decreased.
At the same time, oxymethylene ketone does not have the same effect on cells that are not inflamed after contact with liposugar.
In these cultures, astrocytes continue to produce hyaluronic acid on a regular basis.
(Bioon.
com)
Source of information: com/news/2021-02-biologists-substance-suppress-neuroinflammation.
html">Biologists suggest a new substance to suppress neuroinflammation
html">Biologists suggest a new substance to suppress neuroinflammation
Original source: Dmitry V.
Chistyakov et al, Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone as an Anti-Inflammatory Modulator of LPS-Mediated Astrocyte Responses, International Journal of Molecular Sciences (2020).
DOI: 10.
3390/ijms21218203
Chistyakov et al, Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone as an Anti-Inflammatory Modulator of LPS-Mediated Astrocyte Responses, International Journal of Molecular Sciences (2020).
DOI: 10.
3390/ijms21218203
The team studied the effects of oxymethylene ketone on astrocytes in rat brain cell cultures.
Cell culture samples were first activated with liposugar to activate receptors that activate inflammation, and then treated with oxymethenone.
To evaluate the effectiveness of the drug, the research team extracted RNA from astrocytes and measured the activity of genes that regulate the production of anti-inflammatory molecules.
The levels of hyaluronic acid and cytokines are measured in the cell supernatant.
Use high performance liquid chromatography and tandem mass spectrometry to evaluate the changes in signal lipid (lipoprotein) synthesis.
Cell culture samples were first activated with liposugar to activate receptors that activate inflammation, and then treated with oxymethenone.
To evaluate the effectiveness of the drug, the research team extracted RNA from astrocytes and measured the activity of genes that regulate the production of anti-inflammatory molecules.
The levels of hyaluronic acid and cytokines are measured in the cell supernatant.
Use high performance liquid chromatography and tandem mass spectrometry to evaluate the changes in signal lipid (lipoprotein) synthesis.
Facts have proved that oxymethylene ketone can inhibit the production of anti-inflammatory molecules: tumor necrosis factor α, interleukins IL-6 and IL-1β, and lipoproteins.
At the same time, it increases the development of IL-10 and helps prevent inflammation.
After measuring the level of hyaluronic acid, the research team confirmed that astrocytes actively produce this substance in response to liposugar.
However, when the cell culture at the initial stage of the immune response was treated with oxymethenone, the level of hyaluronic acid decreased.
At the same time, oxymethylene ketone does not have the same effect on cells that are not inflamed after contact with liposugar.
In these cultures, astrocytes continue to produce hyaluronic acid on a regular basis.
(Bioon.
com)
At the same time, it increases the development of IL-10 and helps prevent inflammation.
After measuring the level of hyaluronic acid, the research team confirmed that astrocytes actively produce this substance in response to liposugar.
However, when the cell culture at the initial stage of the immune response was treated with oxymethenone, the level of hyaluronic acid decreased.
At the same time, oxymethylene ketone does not have the same effect on cells that are not inflamed after contact with liposugar.
In these cultures, astrocytes continue to produce hyaluronic acid on a regular basis.
(Bioon.
com)
Source of information: com/news/2021-02-biologists-substance-suppress-neuroinflammation.
html">Biologists suggest a new substance to suppress neuroinflammation
html">Biologists suggest a new substance to suppress neuroinflammation
Original source: Dmitry V.
Chistyakov et al, Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone as an Anti-Inflammatory Modulator of LPS-Mediated Astrocyte Responses, International Journal of Molecular Sciences (2020).
DOI: 10.
3390/ijms21218203
Chistyakov et al, Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone as an Anti-Inflammatory Modulator of LPS-Mediated Astrocyte Responses, International Journal of Molecular Sciences (2020).
DOI: 10.
3390/ijms21218203
Facts have proved that oxymethylene ketone can inhibit the production of anti-inflammatory molecules: tumor necrosis factor α, interleukins IL-6 and IL-1β, and lipoproteins.
At the same time, it increases the development of IL-10 and helps prevent inflammation.
After measuring the level of hyaluronic acid, the research team confirmed that astrocytes actively produce this substance in response to liposugar.
However, when the cell culture at the initial stage of the immune response was treated with oxymethenone, the level of hyaluronic acid decreased.
At the same time, oxymethylene ketone does not have the same effect on cells that are not inflamed after contact with liposugar.
In these cultures, astrocytes continue to produce hyaluronic acid on a regular basis.
(Bioon.
com)
At the same time, it increases the development of IL-10 and helps prevent inflammation.
After measuring the level of hyaluronic acid, the research team confirmed that astrocytes actively produce this substance in response to liposugar.
However, when the cell culture at the initial stage of the immune response was treated with oxymethenone, the level of hyaluronic acid decreased.
At the same time, oxymethylene ketone does not have the same effect on cells that are not inflamed after contact with liposugar.
In these cultures, astrocytes continue to produce hyaluronic acid on a regular basis.
(Bioon.
com)
Source of information: com/news/2021-02-biologists-substance-suppress-neuroinflammation.
html">Biologists suggest a new substance to suppress neuroinflammation
html">Biologists suggest a new substance to suppress neuroinflammation
Original source: Dmitry V.
Chistyakov et al, Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone as an Anti-Inflammatory Modulator of LPS-Mediated Astrocyte Responses, International Journal of Molecular Sciences (2020).
DOI: 10.
3390/ijms21218203
Chistyakov et al, Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone as an Anti-Inflammatory Modulator of LPS-Mediated Astrocyte Responses, International Journal of Molecular Sciences (2020).
DOI: 10.
3390/ijms21218203
Source of information: com/news/2021-02-biologists-substance-suppress-neuroinflammation.
html">Biologists suggest a new substance to suppress neuroinflammation
Source of information: com/news/2021-02-biologists-substance-suppress-neuroinflammation. html">Biologists suggest a new substance to suppress neuroinflammation
Original source: Dmitry V.
Chistyakov et al, Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone as an Anti-Inflammatory Modulator of LPS-Mediated Astrocyte Responses, International Journal of Molecular Sciences (2020).
DOI: 10.
3390/ijms21218203
Chistyakov et al, Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone as an Anti-Inflammatory Modulator of LPS-Mediated Astrocyte Responses, International Journal of Molecular Sciences (2020).
DOI: 10.
3390/ijms21218203
html">Biologists suggest a new substance to suppress neuroinflammation
Original source: Dmitry V.
Chistyakov et al, Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone as an Anti-Inflammatory Modulator of LPS-Mediated Astrocyte Responses, International Journal of Molecular Sciences (2020).
DOI: 10.
3390/ijms21218203
Chistyakov et al, Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone as an Anti-Inflammatory Modulator of LPS-Mediated Astrocyte Responses, International Journal of Molecular Sciences (2020).
DOI: 10.
3390/ijms21218203
Original source: Dmitry V.
Chistyakov et al, Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone as an Anti-Inflammatory Modulator of LPS-Mediated Astrocyte Responses, International Journal of Molecular Sciences (2020).
DOI: 10.
3390/ijms21218203
Original source: Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone as an Anti-Inflammatory Modulator of LPS-Mediated Astrocyte Responses, International Journal of Molecular SciencesChistyakov et al, Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone as an Anti-Inflammatory Modulator of LPS-Mediated Astrocyte Responses, International Journal of Molecular Sciences (2020).
DOI: 10.
3390/ijms21218203
