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Stroke: The decompression skull excision of malignant stroke patients has the significance of intracranial pressure monitoring
Time of Update: 2020-12-17
a recent study published in the authoritative journal Stroke on Cardiovascular Disease, in which researchers investigated the role of invasive ICP monitoring in post-DC MCI patients and hypothesed that postoperative ICP could predict patient mortality.
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Nat Commun: An observational genomic meta-analysis of PTSD in 10 military and civilian queues
Time of Update: 2020-12-17
the study included 10 military and civilian queues, including data on DNA methylation from 1,896 PTSD cases and trauma exposure controls.
after multiple comparison adjustments, the four CpG site points in the aromatic hydrocarbon inhibitor (AHRR) were associated with PTSD, and the degree of DNA methylation in PTSD cases was lower than that of the control group.
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Nat Genet: A study of single nucleotide polymorphisms in Alzheimer's and Parkinson's diseases, revealing variations in the genetic risk points of both diseases
Time of Update: 2020-12-17
analysis of the chain imbalance of neuron-specific GTAS SNPs (image quoted from: Corces, M.R., et al.) Nat Genet 2020; 52: 1158-1168) The above data fully demonstrate the cell type specificity of scATAC-seq data, so is SNPs associated with neurodegenerative diseases rich in specific cell type regions where chromatin access is available?
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JAMA: People who grew up in the era of leaded gasoline more than 30 years ago have shown a decline in IQ in middle age...
Time of Update: 2020-12-17
In a recent study published in the Journal of the American Medical Association (JAMA), an international team of researchers led by Duke University in the United States found that exposure to lead from childhood led to higher blood lead levels associated with lower IQ in middle age and decreased body volume in the sea mass.
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Stroke: The lyic acid state of the cell membrane was negatively related to the prevalence of symptomatic cervical artery disease
Time of Update: 2020-12-17
, cell membrane-rich LA reflects its intake and is negatively associated with symptomatic cervical artery disease.
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Stroke: Cerebral vein thrombosis
Time of Update: 2020-12-17
men (adjusted risk ratio of 1.61 (1.09-2.38)) and older patients had higher long-term mortality rates (1.95 (1.69-2.24) per 10 years of age).
hospitalization rate increased by 5.0 per cent per year, while the hospital mortality rate was lower.
-term mortality increases with age and is higher for men.
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SCI TRANS MED: Clinical data show that brain AAV therapy saves babies from deadly genetic diseases
Time of Update: 2020-12-17
trials included a queue of eight children with mild to moderate illness treated with AAVrh.10hCLN2, and an untreated Will Cornell natural history queue of 12 children.
compared to the Weir-Cornell Natural History Queue (P administration of AAVrh.10hCLN2 may delay the progression of the disease in children with CLN2.
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JNNP: Use a systematic method to select licensed drugs for the treatment of advanced multiple sclerosis
Time of Update: 2020-12-17
Three interventions, R-α-sulphate, metformin and nihilate, as well as a joint preparation of metformin and R-α-thioic acid, were identified as priority drugs for clinical evaluation in the queue of patients with advanced multiple sclerosis, and there was sufficient data to enter phase II trials immediately.
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CELL: The double mutations of histones and PDGFRA promote the occurrence of glioma
Time of Update: 2020-12-17
is thought to be a glioma, G34R/V tumors actually occur in the intermediate neuron progenitocytes expressed by GSX2/DLX, and the G34R/V mutation impairs neuron differentiation.
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Stroke: Effect of sleep apnea on heart embolism risk in patients with atrial fibrillation
Time of Update: 2020-12-17
hypoxia indicators in sleep were associated with elevated CHA2DS2-VASc scores (for individuals with low, moderate, and high risk of cardiovascular disease, the 4% oxygen desaturation index was 17.9, 29.6 and 30.5 events/hour, respectively, with a minimum Spo2 of 81.2, 77.8 and 77.5%, respectively.
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Lancet Neurol: Acetaminophen, modaphine, and methylphenidate have no significant effect on multiple sclerosis fatigue
Time of Update: 2020-12-17
study was conducted at two academic research centers in the United States, involving patients with multiple sclerosis with an MFIS fatigue score of more than 33 points, who were randomly treated with oral acetaminophen (up to 100 mg twice a day), modapheone (up to 100 mg, twice a day), methamphetamine (up to 10 mg, twice a day) or placebo for up to 6 weeks per drug intervention.
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JAHA: The efficacy of anti-thrombosis drugs on tPA-induced cerebral hemorrhage
Time of Update: 2020-12-17
, researchers conducted a systematic evaluation and meta-analysis of preclinical studies to assess the efficacy of antithrombosis drugs for hemorrhagic conversion caused by tPA after ischemic stroke, according to a recent study published in JAHA, an authoritative journal in the field of cardiovascular disease.
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JNNP: The Efficacy of Oral Understanding Therapy in Patients with Chronic Aphpathy: A Cross Randomized Controlled Trial Based on SmRI
Time of Update: 2020-12-17
participants with chronic aphdversia after a stroke and impaired oral understanding completed continuous "listen-in" and standard care (two 12-week, random groupings).
results of the first study (Auditory Understanding Test (ACT)) showed significant improvements in trained spoken language at 12 and 24 weeks compared to standard treatment (11 per cent, Cohen'd=1.12).
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Stroke: The occurrence and outcome of haemorrhage in the lower cavity of the aneurysm cobweb
Time of Update: 2020-12-17
between 1 January 2009 and 31 December 2014, the researchers included all patients admitted to hospital throughout Switzerland who were diagnosed with haemorrhage in the lower cavity of the aneurysm cobwebs in a forward-looking registration centre.
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Acta Neurol Scand: Six months of dance movement intervention can alter the brain structure of non-dementia elderly people
Time of Update: 2020-12-17
6 months, the cortical cortical area of the lower right armpage, spindle shape and outer pillow of the DI subjects increased significantly compared to the control group.
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JNNP: The burden of haemorrhage death in the lower cavity of the sarcoma of middle-life people is relatively high
Time of Update: 2020-12-17
because cancer, transportation, alcohol and cardiovascular-related deaths are declining in high-income countries, the authors hypothesically assume that the proportion of aSAH deaths in the middle age group may increase.
therefore, the purpose of this paper is to determine the proportion of aSAH deaths among middle-age people and other causes of death.
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Acta Neuropathologica: Large-scale pathway-specific multigene risk and transcription group community network analysis identifies new functional pathways for Parkinson's disease
Time of Update: 2020-12-17
by assessing the effects of rare mutations on the risk of Parkinson's disease in a separate set of genome-wide sequencing data, the authors found evidence of a devastating allied gene burden that is rare in a range of processes, including neuron transmission-related pathways and immune responses.
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Lancet Neurology: The Safety and Effectiveness of Fluoxetine on The Prognostic Prognostication of Acute Stroke Function (AFFINITY): a randomized, double-blind, placebo-controlled trial
Time of Update: 2020-12-17
this paper, the AFFINITY trial was designed to assess whether oral fluoroxitine daily for six months after stroke in different ethnic groups improved functional outcomes.
Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial.
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Stroke: Intracranial aneurysms are associated with Marfan syndrome
Time of Update: 2020-12-17
, researchers aim to assess the prevalence and characteristics of IA in MFS patients using brain imaging and compare it to the general population, according to a recent study published in TheStroke, an authoritative journal in the field of cardiovascular disease.
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Lancet Neurol: Any AHM with a blood-lowering effect can reduce the risk of dementia
Time of Update: 2020-12-16
in people with high blood pressure levels, the use of any AHM with antihypertensive effects may reduce the risk of dementia.
