Lancet Neurol: Any AHM with a blood-lowering effect can reduce the risk of dementia

Dementia is a major public health problem affecting human health, but its prevention and treatment can not be solved.
previous studies have shown that specific antihypertensive drugs (AHMs) reduce the burden of hypertension.
study published recently in Lancet Neurol explores whether specific AHM classes can reduce the risk of dementia, and the results suggest that any AHM with a blood pressure-lowering effect can reduce the risk of dementia.
researchers conducted a meta-analysis of eligible observational studies published between 1 January 1980 and 1 January 2019.
incorporated forward-looking cohort studies that recruited adults living in the community, included more than 2,000 participants, collected data on dementia events for at least five years, measured blood pressure and verified AHM use, included clinical and complementary tests, and followed up on cases of mortality.
assessment is associated with dementia events and clinical Alzheimer's disease in the baseline high (systolic pressure sbP≥140 mm Hg or espressopressurization (DBP) ≥90 mm Hg) and normal (SBP<140 mm Hg and DBP <90 mm Hg) blood pressure stratums.
use tendentity scores to control the confuse factors associated with the probability of accepting ACM.
using a meta-analysis of random effects brought together estimates of specific effects of the study.
results, the study included six prospective community studies (including 31,090 adults over the age of 55 with no dementia esolyses) with a medium follow-up time of 7-22 years.
confirmed 3,728 cases of dementia and 1,741 cases of Alzheimer's disease.
in the hypertension layer (n=15 537), people who use any ACM have dementia (risk ratio of 0-88,95% CI 0-79-) compared to those who do not use AHM Reduced risk of 0-98; p-0-019) and Alzheimer's disease (HR 0-84, 0-73-0-97; p-0-021).
found no significant difference in the risk of dementia between one class of drugs and all other drugs.
in normal stratation of blood pressure (n-15 553), there was no association between the use of AHM and the onset of dementia or Alzheimer's disease.
, the findings suggest that no class of AHM drugs has been found to be more effective in reducing the risk of dementia.
in people with high blood pressure levels, the use of any AHM with antihypertensive effects may reduce the risk of dementia.
findings suggest that future clinical guidelines for hypertension management should also consider the beneficial effects of AHM on dementia risk.
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