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The study found that GABA, which induces cognitive impairment of depression co-disease in youth, can have synth regulation mechanism
Time of Update: 2020-12-12
researchers further increased BDNF signaling pathogenic activity by single acute microindulation BDNF TrkB subjectors in model animals, and found that social interest and cognitive impairment induced by youth stress can be quickly restored and mPFC GABA can be reversed for synaptic delivery inhibition, but this improvement does not include anxiety-like behavior (Figure 3).
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Alzheimer's and Dementia: Genetic mutations affect the development of Alzheimer's disease
Time of Update: 2020-12-12
() Source: Novel gene variants that modify the source of the modified risk of late-onset Alzheimer's disease foundeded: Young Won Kim et al, Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 identify to genetic modifiers in Alzheimer's disease, Alzheimer's and Dementia (2020).
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PNAS: How the brain remembers accurate information about time and space
Time of Update: 2020-12-12
, associate professor of neurosurgery at UTSW and senior author of the PNAS study, explained that the cells are located in the brain's hemass and show characteristic patterns of activity when animals encode and remember events.
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Lancet Neurology: Long-term follow-up to the ORATORIO trial: Early and ongoing ocrelizumab therapy is beneficial to the progress of primary aggressive MS
Time of Update: 2020-12-11
Long-term follow-up from the ORATORIO trial of ocrelizumab for primary progressive multiple sclerosis: a post-hoc analysis from the ongoing open-label extension of the randomised, placebo-controlled, phase 3 trial.
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Stroke: Analysis of the efficacy of the treatment of large vascular thrombosis patients with venous thrombosis
Time of Update: 2020-12-11
researchers searched the MEDLINE and Scopus databases for published randomized controlled clinical trials that provided outcomes in patients with acute ischemic stroke and were diagnosed with LVO and received different doses of sterols or standard doses of 0.9 mg/kg atipase.
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The study found the interaction between IL-10 and COMT gene polymorphism in cognitive function in patients with schizophrenia
Time of Update: 2020-12-11
's effects on COMT are similar, for example, Met-type carriers, traditionally thought to have higher cognitive function, actually have better cognitive function only if they have the IL-10 C gene at the same time; may be due to the fact that both dopamine and inflammatory systems play an important role in cognitive function, not the balance of the system rather than the level.
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Lancet Neurology: Early-8 protein-1 E280A normal chromosomal explicit Alzheimer's family plasma nerve wire light chain: a cross-sectional and longitudinal cohort study
Time of Update: 2020-12-11
In this study, the authors' team used available cross-sectional plasma samples to show NfL concentrations in participants at the Alzheimer's Prevention Initiative Registry in Colombia, including age-matched early-onset protein-1 (PSEN1) E280A mutation carriers and non-carriers.
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Cell Death Dis: Drug CBL0137 Effectively Inhibits MYC Amplified Type 3 Myeloma (MYCamp-G3-MB)
Time of Update: 2020-12-11
recent studies have shown that a number of oscic genetically targeted treatment strategies can effectively treat preclinical models of MYCamp-G3-MB, including the inhibition of BET, hdAC and SETD8, which also provides a promising direction for further research into the disease.
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Cell interpretation! Revelation.
Time of Update: 2020-11-30
NGF and other factors promote the growth of nerve tissue in pancreatic tumors and increase tumor growth, the researchers revealed for the first time that axons, as an extension of the nerve cells that transmit information, can provide metabolic support to cancer cells by secreting serine in nutrient-poor areas.
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What exactly is cancer? What are the types? Look at this and you'll see
Time of Update: 2020-11-30
osteosarcoma starts in bone cells and is the most common bone cancer; leukemia is a cancer that originates in myeloid hematosis tissue and is the most common type of cancer in children and does not form a solid tumor.
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Medium GDF-15 reduces vomiting, anorexia, and body weight caused by platinum chemicals...
Time of Update: 2020-11-30
Breen research team of Pfizer published an online article in Cell-Metabolism entitled "GDF-15 Neutralization Alleviates Platinum-Based Process-Induced Emesis, Anorexia, Weight and Loss in Mice and Nonhuman Primates." they found that in mice and non-human primates, the growth differentiation factor 15 (GDF-15) reduced vomiting, anorexia and weight loss caused by platinum chemicals.
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Nature: Use K18-hACE2 mice to evaluate COVID-19...
Time of Update: 2020-11-30
they found that SARS-CoV-2 infection with K18-hACE2 mice causes dose-dependent fatal respiratory diseases characterized by severe human COVID-19, including diffuse alva damage, inflammatory cell immersion, tissue damage, pulmonary vascular damage, and death, some of which can result in brain infections.
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Neuron: Scientists have developed new ways to restore myelin function in damaged nerve cells or hopefully help treat multiple sclerosis
Time of Update: 2020-11-29
researcher He points out that in mouse models of optic nerve damage, we found that most axons may have myelin regeneration when combined with therapy to remove small glial cells after damage to the body.
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EMBO J: Scientists have discovered an "alternate" mechanism in the brain that effectively removes harmful cell fragments
Time of Update: 2020-11-29
November 16, 2020 // -- Small glial cells, special immune cells in the brain, play a major role in removing cell fragments from the brain, a study published in the international journal The EMBO Journ
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Stroke overall program provider Warby Medical completed hundreds of millions of dollars in round C financing
Time of Update: 2020-11-29
Wobi Medical Avenir™ mechanical free spring ring has completed domestic clinical trials, and passed the National Drug Administration's application for special examination of innovative medical devices, is the field so far the only access to the special examination procedures "green channel" products, is expected to be listed in the domestic forensics next year.
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mSphere: Regulating the microbiome can treat autism
Time of Update: 2020-11-29
further research will help to improve understanding of the complex and important interactions between the gut microbiome and ASD-related neurological characteristics, and will help fine-tune MTT therapy or other microbial-based therapies to be more effective in alleviating ASD symptoms.
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J Clin Psych: New research finds! People in their 20s are the loneliest, while people in their 60s are the least alone!
Time of Update: 2020-11-29
The researchers point out that compassion seems to help reduce the level of loneliness in people of all ages, perhaps by making individuals more accurately perceive and understand other people's emotions and helpful behaviors, while also increasing their social self-efficacy and ability to socialize online.
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Sci Adv: Research reveals why people can see 3D images
Time of Update: 2020-11-29
"The genetic mechanisms we have identified ensure that some neurons located in the retina transmit visual information to the opposite hemisphere of the brain, and the Zic2 protein shuts down the program in the retinal neurons, allowing visual signals to reach the same hemisphere." ago, Dr. Eloísa Herrera's team found that Zic2 ensures that the extension of neurons (axons) remains in the same hemisphere as its origin.
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Sina Medicine Live Lesson 9 The breakthrough in the administration of myopia treatment drugs
Time of Update: 2020-11-29
In order to provide innovative pharmaceutical practitioners with a free and smooth exchange platform, Sina Pharmaceuticals has launched a "New Zhihui" online live knowledge sharing platform, which will focus on hot topics such as target discovery, new technology development and application, process development and verification, drug clinical trial design, and so on, through strategy and case sharing, directly hit the confusion in research and development production.
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JAD: Obstructive sleep apnea is directly related to an increased risk of dementia in the population
Time of Update: 2020-11-29
November 16, 2020 // -- Scientists from Monash University and others have found that obstructive sleep apnea (OSA, obstructive sleep apnea) may be directly related to high-risk dementia in a recent st
