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Nat Commun: An alternative to aspirin? Scientists have developed synthetic blood anticoagulants that do not increase the risk of bleeding!
Time of Update: 2020-08-25
Recently, researchers from the University of Bern and the Federal Institute of Technology in Lausanne, Switzerland, designed a highly active and stable FXII cyclopeptide inhibitor (FXII900) that reduces experimental thrombosis caused by iron chloride in mice and inhibits blood clotting in rabbits' inositive membrane oxygenation (ECMO) environments without increasing the risk of bleeding and is a promising candidate for safe thrombosis protection in acute medical conditions.
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Lancet Digital Health: New treatments for insomnia can improve sleep and reduce sleep drug dependence.
Time of Update: 2020-08-25
A team of researchers at the Norwegian University of Science and Technology has found for the first time that digital cognitive behavioural therapy (dCBT-1) conducted online not only reduces the severity of insomnia-related symptoms, but also helps reduce patients' dependence on sleep medications and improves their physical and mental health.
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PNAS: Significant progress! Scientists identify optic neural stem cells for the first time, or can treat vision loss!
Time of Update: 2020-08-25
Currently, more than 3 million Americans suffer from glare and cause blindness in 120,000 patients. glare is a disease caused by damage to the optic nerve, which is usually associated with the intra-
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JAMA Neurol: Thirty percent of stroke patients have substandard blood pressure.
Time of Update: 2020-08-25
study in China found that even though seven adults knew they had high blood pressure, only 20 percent received antihypertensive treatment and had blood pressure within the target range.
data showed that 37.1% of patients had substandard blood pressure, and 80.4% of them took anti-pressure drugs.
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J Thromb Haemost: Benzodiazepines and venous thrombosis risk.
Time of Update: 2020-08-25
From January 1, 2002 to December 31, 2012, researchers analyzed Taiwan's claims database and conducted a nested case-control study of patients with at least one new BZRA prescription, including new user years two years ago without any BZRA prescriptions, and identified cases with VTE and disease risk scores and matching comparors.
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Acta Neuropathol: Gene new therapy beats you to reverse Alzheimer's-related memory loss.
Time of Update: 2020-08-25
July 29 A study by the brothers, Arne Ittner and Professor Lars Ittner of the Dementia Research Centre at Macquarie University in Sydney, Australia, showed that the active form of tau kinase p38 to neurons could improve the cognition of mice with AD models that already had significant memory impairments.
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JAHA: Relationship between vascular risk factors and APOE genotypes and vascular gaps in the elderly.
Time of Update: 2020-08-25
, a study published in JAHA, an authoritative journal in the field of cardiovascular disease, looked at whether vascular risk factors in older adults were associated with PVS.
, the study provides limited evidence to support a correlation between PVS on MRI and traditional vascular risk factors in older adults.
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Neuron: Precise positioning! Make the body's biological clock work properly.
Time of Update: 2020-08-25
In a new study published in Neuron on Aug. 8, a team from the University of Texas Southwestern Medical Center (UTSW) developed a bioluminescent circadian rhythm genetically engineered mouse and related imaging system that visualizes biological clock fluctuations in mouse cells.
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FDA approves oral spinal muscular dystrophy (SMA) drug Evrysdi.
Time of Update: 2020-08-25
Recently, the FDA approved Evrysdi (risdiplam) from Roche and its partner PTC Therapeutics, making it the first oral treatment for all types of spinal muscular dystrophy (SMA) patients with two months and more.
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Acta Neuropathologica: Serum-negative severe muscle weakness patient neuromuscular joint complement deposition.
Time of Update: 2020-08-25
contrast, serum antibodies against muscle-specific tyrosine kinase (MuSK-ab, present in 3% of patients with severe muscle weakness) mostly come from IgG4 subtypes that do not activate the complement system.
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AAIC 2020: Phase II clinically confirmed that recombinant GM-CSF has therapeutic potential for Alzheimer's disease.
Time of Update: 2020-08-25
: Results of the Phase 2 double-blind trial showed that patients who received daily subderrical injections of sargramostim 250 mcg/m2 had an average minimum mental state test (MMSE) score that improved compared to the baseline level (P .0074).
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JAMA Neurol: The risk of ischemic cerebrovascular events increased in patients with asymptomatic cervical arterial stenosis characterized by high-risk plaques in imaging.
Time of Update: 2020-08-25
In studies focusing on severe stenosis (9 cohorts, 2128 participants; average follow-up period 2.8 years), the occurrence rate of ischemic cerebrovascular events was 3.7 cases/100 years in patients with high-risk plaques The rate of hemocycular vascular events (7.3 cases/100 patient years) was also higher than in patients without high-risk plaques (1.7 cases/100 patient years) and the risk ratio was 3.2 (I2 x 39.6%).
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JAMA: The latest brain death verdicts are out! The world's expert consensus on brain death.
Time of Update: 2020-08-25
group recommended that brain death/neurodegeneration be defined as complete and irreversible loss of brain function, i.e. coma without response, loss of consciousness, disappearance of brain-dry reflexes, and inability to breathe autonomously.
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Save the frozen life! This MDT team became the "king" of Parkinson's disease.
Time of Update: 2020-08-25
installed a pacemaker and no longer trembled on July 17th, under the guidance of Professor Chen Qian, the MDT team of Parkinson's Disease of Wuhan University People's Hospital performed deep brain electrical stimulation surgery on Zhao's father.
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A case of brain abscess after deep electrostimulation in patients with plant state was reported and reviewed in literature.
Time of Update: 2020-08-24
this study summarizes and analyzes the diagnosis and treatment of brain abscesses that occur after DBS surgery in 1 patient with plant state, and discusses the factors, prevention and treatment measures of DBS postoperative SSI in the light of literature review.
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2 cases of acute diffuse brain swelling.
Time of Update: 2020-08-24
2 h, the patient is irritable, the left pupil is scattered large, the light reflection disappears, review the brain CT found that the left armatum pillow epidural hematoma, the middle line is right.
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Diabetes Obes Metab: Removing chronic hepatitis C virus infection can reduce the incidence of type 2 diabetes.
Time of Update: 2020-08-24
, however, it is not clear whether the removal of HCV through direct-acting antiviral drugs (DAA) will reduce the T2DM rate.
, HCV removal reduced T2DM's RR and HR by 81% and 75-93%, respectively, compared to the control group.
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1 case of brain abscesses caused by austere.
Time of Update: 2020-08-11
After admission to the hospital 24d patients develop fever, body temperature 39.0 degrees C, WBC 17.16 x 109/L, NEU13.76 x 109/L, LYM2.49 x 109/L, NEUT%80.2%, review of the head-enhanced CT-indicated pus cavity increased.
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JAMA Neurol: Continuous immunotherapy in patients with secondary progressive multiple sclerosis reduces the risk of disability progression.
Time of Update: 2020-08-11
the main endpoint of the study was the accumulation of disability in SPMS patients as a measure, and two results were analyzed: disability accumulation rate in the second progress ionphase phase and risk of wheelchair dependence.
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Acta Neuropathologica: The effect of BTK's inhibition on the progression of pathogenic B cells in inflammatory central nervous system demyelinopathy.
Time of Update: 2020-08-11
Summary: The data in this paper establish and emphasize the therapeutic BTK inhibition of disease-driven B-T cell interactions in inflammatory central nervous system demyelination and does not require permanent removal of any cell type.
