JAHA: Relationship between vascular risk factors and APOE genotypes and vascular gaps in the elderly.

There is evidence that enlarged vascular pervasive gap (PVS) may be a sign of cerebrovascular disease.
, a study published in JAHA, an authoritative journal in the field of cardiovascular disease, looked at whether vascular risk factors in older adults were associated with PVS.
the population-based study included 530 participants (aged 60) who had no dementia or functional dependence from the Swedish National Study on Aging and Nursing (2001-2003).
researchers collected participant data on demographics, vascular risk factors, and health status through interviews, clinical tests, laboratory tests, and patient registration.
the researchers used semi-quantitative visual assessment scales to visually assess the high intensity of brain PVS and white mass on magnetic resonance images, and analyzed the data using general linear regression models.
after controlling demographic and cardiovascular disease, very high blood pressure (-160/100 mmHg) was significantly associated with overall PVS scores (beta factor 1.30; 95% CI was 0.06-2.53), positional hypotension was associated with the PVS score of the basal nerve section (beta coefficient 0.37; 0.03-0.70), but the correlation became less significant when adjusting for white mass overload.
hypotensive hypotension was significantAPOEε4ly associated with the overall and brain leaf PVS scores of alletope gene carriers, but not with non-carriers.
overall or regional PVS scores were not significantly associated with other traditional vascular risk factors such as smoking, diabetes, lack of exercise, and being overweight or obese.
, the study provides limited evidence to support a correlation between PVS on MRI and traditional vascular risk factors in older adults.
link between erect hypotension and APOEε4 carriers of brain leaf PVS suggests that brain leaf PVS may be a sign of amyloid-related small vascular disease.
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