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Post-traumatic stress disorder (PTSD) is characterized by re-experience, avoidance, and excessive feverish symptoms that can have a negative impact on emotional and physical health.
that while not everyone who has experienced trauma develops post-traumatic stress disorder, those who experience trauma tend to experience severe disability symptoms.
that genetic and environmental factors can lead to a risk of post-traumatic stress disorder.
differences may help distinguish between PTSD cases and trauma exposure control groups.
, the researchers described the results of the largest meta-analysis of PTSD DNA methylation to date.
the study included 10 military and civilian queues, including data on DNA methylation from 1,896 PTSD cases and trauma exposure controls.
after multiple comparison adjustments, the four CpG site points in the aromatic hydrocarbon inhibitor (AHRR) were associated with PTSD, and the degree of DNA methylation in PTSD cases was lower than that of the control group.
although AHRR methylation is known to be associated with smoking, the association between AHRR and PTSD is most pronounced among non-smokers, indicating that the results are not related to smoking status.
of metabolomic data showed that AHRR methylation was associated with canine urea levels, which were lower among PTSD subjects.
the study supports the differences in the surface genetics of PTSD patients and suggests that decreased urea in dogs is a factor in PTSD immune disorders.
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