JAHA: The efficacy of anti-thrombosis drugs on tPA-induced cerebral hemorrhage

Tissue-type lysase primary activators (tPA) remain the only drugs approved for acute ischemic stroke, with potentially serious adverse effects: hemorrhagic conversion.
the effects of antithrombosis drugs on hemorrhagic conversion caused by tPA after ischemic stroke.
, researchers conducted a systematic evaluation and meta-analysis of preclinical studies to assess the efficacy of antithrombosis drugs for hemorrhagic conversion caused by tPA after ischemic stroke, according to a recent study published in JAHA, an authoritative journal in the field of cardiovascular disease.
researchers systematically evaluated and meta-analyzed the study of anti-suppository effects in tPA-induced hemorrhagic transformation animal models, calculated the combined effects using random effect models, and explored heterogeneity through meta-regression and subgroup analysis.
researchers used dressing and filling methods and Egger tests to assess publishing bias.
22 documents describe the efficacy of 18 different interventions.
data showed significant improvement in cerebral hemorrhage, infarction area and neuro-behavior prognosis in the treatment group compared to the control group (standardized average difference of 0.45 (95% CI is 0.11-0.78); The difference is 1.18 (95% CI is 0.73-1.64) and the standard average is 0.91 (95% CI is 0.49-1.32).
subgroup analysis showed that quality score, random distribution, temperature control, use of anesthetics, stroke models used, route of drugation, dosing time and evaluation time were important factors affecting the efficacy of intervention.
result, antiplate plateboard drugs improved significantly in all outcomes.
anticoagulants had a significant effect on infarction area and nerve behavior scores, but fiber solvents showed no significant improvement in all outcomes.
this conclusion should be interpreted with caution in view of the heterogeneity and published bias found in this analysis.
。