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Explore the molecular mechanism of memory function formation
Time of Update: 2021-03-22
Source: SCIEPRO/GETTY In January 2020, Wang Xiaoqun, a researcher at the Institute of Biophysics, Chinese Academy of Sciences, and Wu Qian, a professor at Beijing Normal University, and others published a paper in the journal Nature [1], revealing the dynamic development process of the human hippocampus.
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A major breakthrough in Alzheimer's treatment! The clinical data for the no-invasive black technology Phase 2 of MIT Neuroscience Bull were published, and the six-month treatment significantly delayed the decline in cognitive function by 83% | Clinical discovery
Time of Update: 2021-03-22
According to the currently published data, a 1-hour-a-day, 6-month treatment can significantly delay the disease progression of patients with mild to moderate AD, the activity of daily living scale (ADCS-ADL) score decrease by 84%, and a simple mental status check The decline in MMSE scores has slowed by 83%, and brain atrophy has been significantly reduced by 61%!
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Depression and pain altogether "another city", Professor Zhang Zhi reveals the different neural circuits of different types of pain
Time of Update: 2021-03-22
To further confirm the changes in the above-mentioned neuronal activity in pain model mice, the researchers used the optical fiber calcium imaging recording system to dynamically observe the changes in the calcium ion concentration of PO-Glu neurons in real time.
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Acute treatment of cluster headache, a shorthand
Time of Update: 2021-03-22
*Only for medical professionals to read the reference book of the attending physicians in God, make a little progress every day~References: [1] Wang Weizhi.
1001 Questions for the Attending Doctor of Neurology (5th Edition) [M], Peking Union Medical College Press, 2017.
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The first 3 fingers on the radial side of the patient's right hand are tingling and numb. What is the most likely diagnosis?
Time of Update: 2021-03-22
Answer: C6 cervical radiculopathy learning points: The patient showed hand numbness, biceps weakness, and loss of biceps reflex, and the Tinel sign was negative.
This patient showed weakness in the proximal muscles of the hand, and carpal tunnel syndrome can be ruled out.
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Zhang Zhi et al. reveal the neural mechanism of the side effects of the anti-breast cancer drug tamoxifen
Time of Update: 2021-03-22
Through tissue specificity Gene knockout and single-cell sequencing revealed that the estrogen receptor alpha (ERα) located in the hypothalamus is a key target that mediates tamoxifen's metabolic side effects such as hot flashes.
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Neurology: Remote cognitive behavioral therapy can effectively intervene the depression of Parkinson's patients
Time of Update: 2021-03-22
and others of Rutgers–Robert Wood Johnson Medical School in the United States explored whether telephone-based cognitive behavioral therapy (T-CBT) is better than conventional therapy (TAU) for patients with depression and Parkinson's disease (PD) It can significantly alleviate the symptoms of depression.
Telephone-based cognitive behavioral therapy for depression in Parkinson disease: A randomized controlled trial.
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Song Juxian/Tang Chunzhi’s collaborative team discovered a new mechanism for electro-acupuncture (electro-acupuncture) to alleviate the pathology of Alzheimer’s disease and enhance cognitive function
Time of Update: 2021-03-22
TNEA induces the degradation of full-length and C-terminal APP and Aβ, and inhibits the activation of glial cells in the prefrontal cortex and hippocampus, preventing the occurrence of neuroinflammation; in terms of mechanism, TNEA activates downstream TFEB by inhibiting the AKT-MAPK1-MTORC1 pathway to improve The autophagy-lysosomal pathway in the brain degrades APP and Aβ, alleviates neurotoxicity, and ultimately exerts a neuroprotective effect and increases cognitive function (Figure 3).
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MN︱ Yang Li’s research group reveals a new mechanism of early Alzheimer’s disease olfactory abnormalities: enhancing GABA signaling pathway to improve olfactory bulb gamma oscillation abnormalities
Time of Update: 2021-03-22
Professor Yang Li’s research group from the School of Life Sciences, Guangzhou University has long been committed to revealing: (1) the pathological mechanism and early biomarkers of the neurodegenerative disease Alzheimer’s disease; (2) β-amyloid precursor (APP) The neuron and synaptic functions of humans; and (3) the neurobiological basis of emotions and social behaviors.
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A 32-year-old man suffered a stroke and was admitted to the hospital. He did not get better after 1 week of treatment. The reason was...
Time of Update: 2021-03-22
Combined with the patient's clinical manifestations, imaging examinations, cerebrospinal fluid and cardiac ultrasound examinations, the patient's final diagnosis was: left atrial myxoma caused multiple cerebral embolism.
Cerebral embolism caused by atrial myxoma is the most common form of thrombus shedding.
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The effects of social isolation on the human neural circuits during the | Cell Press Paper Express
Time of Update: 2021-03-22
The neural composition of social balance Social balance is a personal ability to detect the quantity and quality of social contact, compare it with the established set point of the command center, and adjust the energy spent seeking social contact through the effect system (Figure 1 and Table 1) (Matthews and Tye, 2019).
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Suzhou Nano Institute developed nano-medicine-mediated stem cell therapy for Alzheimer's disease
Time of Update: 2021-03-22
The water maze behavior of AD mice after a single treatment for 1 and 6 months The analysis showed good memory and cognitive improvement (Figure 3).
Related research results were published on Advanced Materials with the title A Nanoformulation-Mediated Multifunctional Stem Cell Therapy with Improved Beta-Amyloid Clearance and Neural Regeneration for Alzheimer's Disease.
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Science journal: New research reveals why APOE4 increases the risk of Alzheimer's disease
Time of Update: 2021-03-22
Related research results were recently published in the journal Science Translational Medicine, with the title of the paper "APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia".
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Cell Stem Cell: Key protein promotes spinal injury repair
Time of Update: 2021-03-22
Animals engineered to overproduce SOX2 in NG2 glial cells have significantly better motor skills in the weeks after spinal cord injury than animals that produce normal SOX2In the end, researchers may be able to find a safe and effective way to overproduce SOX2 in human spinal cord injury patients, thereby helping them repair the damage with new neurons while reducing the formation of scar tissue.
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Large-scale research observes: the brains of homosexuals are different from heterosexuals
Time of Update: 2021-03-22
In August 2019, a large genome-wide association analysis (GWAS) of nearly 500,000 people published in Science magazine showed that there is no single "homosexual gene" that affects sexual orientation [1].
However, the neurobiological association of sexual orientation and the relationship between genetic factors and brain structural variations have not been well studied.
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Drug treatment strategies and dosage optimization for epilepsy, mastered in one article
Time of Update: 2021-03-22
*Only for medical professionals to read for reference. Pure dry goods sharing, bookmarked! Epilepsy (epilepsy), commonly known as "saw horn wind" or "sheep epilepsy", is a chronic disease in which t
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High risk of inherited Alzheimer's disease, or can it be reversed by "food supplement"?
Time of Update: 2021-03-22
Recently, a study led by Professor Lihui Cai, a neuroscientist at the Massachusetts Institute of Technology (MIT) and a collaborator, gave us a new understanding of the role of the APOE4 gene in the development of Alzheimer's disease.
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【Weekly Questions】The first 3 fingers on the radial side of the patient's right hand are tingling and numb. What is the most likely diagnosis?
Time of Update: 2021-03-22
While answering the questions, please leave a message with your answers and diagnosis and treatment ideas to us.
The answer will be announced tomorrow, and we will see or leave!
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A new chapter in regeneration research: Yale research team "unlocks" 40 genes that hinder nerve repair
Time of Update: 2021-03-22
In the retina of glaucoma mice, the researchers relieved the inhibitory effect of this gene by inhibiting IL-22, and found that the axon regeneration ability of the mouse optic nerve was greatly enhanced and nerve repair was improved.
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Come to challenge: diagnosis and treatment of Parkinson's disease, try your skills in 7 cases!
Time of Update: 2021-03-22
The T2-weighted image of the MRI of the brain of patients with MSA shows a cross-shaped (bread) sign in the axial view of the pons (see Figure 3).
The following MRI brain T2-weighted image shows the "double panda sign" characteristic of Wilson disease.
