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Neurology: The presence and prognosis of micro-bleeding in the brain is not related to the post-stroke vascular thrombosis
Time of Update: 2021-02-02
, Imad Derra of Hôpital Gui de Chauliac, France, et al., explored whether the presence and burden of pre-EVT CMB was associated with clinical outcomes in the three months after ICH and AIS.
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Neurology: Gaps around blood vessels are an independent risk factor for dementia
Time of Update: 2021-02-02
severe PVS pathology is a sign of cognitive decline and an increased risk of dementia, independent of other small vascular disease markers.
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NICE UK rejects Zeposia's role in treating multiple sclerosis
Time of Update: 2021-02-01
, NICE said in an evaluation consultation that while there is evidence that Zeposia can reduce the number of relapses and brain lesions in patients with multiple sclerosis compared to interferon beta-1a, it is not clear how the drug affects disability progression.
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JAMA Netw Open: Supplementing high doses of vitamin D during pregnancy does not improve neurodevelopment in future generations
Time of Update: 2021-02-01
, when neurodevelopmental assessments were conducted, the addition of high doses of vitamin D had no effect on the overall cognitive score of 3-year-olds compared to the standard dose.
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Neurology: A 10-year follow-up found that early reduction of A-beta deposition may help prevent Alzheimer's disease
Time of Update: 2021-02-01
, William J Jagust of the University of California, Berkeley, et al., based on the well-known Alzheimer's Disease Neuroimaging Initiative, explores the relationship between the cognitive normality of A-beta-negative and the time process and cognitive prognostication of the positive conversion of A-beta-positive.
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A detail of the geryration patient caught the doctor's attention, and the result was a heart attack!
Time of Update: 2021-02-01
Chen Pengcheng heard anxiously, in the phone bitterly advised: "the electrocardial results do not exclude the heart attack, although now looks good, but at any time may happen unexpected, very dangerous." , no matter what urgent matters at home now, please put it down immediately, hurry to the hospital to continue to check and treatment.
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Acta Neuropathologica: In a series of 83 diffuse midline gliomas with H3F3A K27M mutations, FGFR1 mutations were associated with better prognosis
Time of Update: 2021-02-01
over time, we observed individual DMG cases accompanied by mutations within FGFR1 or BRAF.
, parallel occurrences of H3 and FGFR1/BRAF mutations in a single tumor may complicate diagnostic decisions for low- or high-level gliomas, but are also clinically significant.
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Neurology: Analysis of incidence, prevalence and geographical clustering of motor neurone disease in the Netherlands
Time of Update: 2021-02-01
in this prospective cohort study, researchers used Poisson regression to assess the time trend of MND risk and calculated age and gender standardization, observation and expected cases in 1,694 regions.
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JNNP: A unique pattern of temporal lobe atrophy in patients with frontal temporal lobe dementia and I383V variation in TARDBP
Time of Update: 2021-02-01
Frontal temporal lobe dementia (FTD) and amyotrophy lateral sclerosis (ALS) are closely related diseases that are pathologically and genetically linked through TAR-DNA binding protein-43 (TDP-43).
pathogenic variants in TARDBP coded TDP-43 appear less frequently in FTD than ALS, and clinical pathology studies are rare.
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JNNP: Relationship between bladder fore limb imaging and the efficacy of inner cystic indiesis in patients with obsessive compulsive disorder
Time of Update: 2021-02-01
this study focuses on specific functional pre-frontal areas associated with obsessive compulsive disorder, including the outer frontal cortical cortical layer (dlPFC), the pre-cortical (OFC), the outer abdominal PFC (vlPFC) (or lower prey cortical cortical), Back-side front buckleback (dACC) and abdominal inner (vmPFC), using fiber beam imaging analysis, focused on the number of whiteness characteristics of aLIC in patients with obsessive compulsive disorder by connecting the symposome, the pasal brain, and the pre-frontal leaf region of the STN cortical subsurface.
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Neurology: Interstuming stem cells are safe and feasible for treating stroke
Time of Update: 2021-02-01
the STARTING (Stem Cell Application Researches and Trials In NeuroloGy) trial, a randomized controlled trial of intravenously administered fetal bovine serum (FBS)-cultured self-filled stem cells (MSCs), showed that the efficacy of MSC therapy needed to be improved.
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Neurology: Incidence, prevalence, and outcome of idynial intracranial hypertension
Time of Update: 2021-02-01
researchers recorded body mass index (BMI), resource deprivation five-digits, cerebrospinal fluid re-correction surgery, and unplanned hospitalization in the case and control groups.
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Acta Neuropathologica: Misalmed variation in TTN-related congenital myopathy
Time of Update: 2021-02-01
Recent studies have shown that TTN mutations have become the main cause of explicit and recessive hereditary myopathy, and their scope is widespread and expanding, including tibia muscular dystrophy (TMD), muscular dystrophy 2 J (LGMD2J), hereditary myopathy with early respiratory failure (HMERF), Salih myopathy, central transparent myopathy (CNM), heart disease core myopathy, and so on.
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Neurology: Cerebrospinal amyloid is closely related to the sea horse-related memory
Time of Update: 2021-01-31
The test, which is designed to assess the core function of the hippo horse and endoencephalic cortical layer (the early region of the inner temporal lobe MTL affected by tangle) pathology), may be sensitive to subtle changes in memory associated with biomarker abnormalities, in particular the elevation of p-tau181, which is associated with tangle pathology.
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Neurology: Bone density is closely related to small vascular disease
Time of Update: 2021-01-31
, several studies have found a positive correlation between increased arterial stiffness and the burden of brain SVD.
decreased bone density is associated with increased vascular calcification and arteriosclerosis, which can aggravate arterial stiffness and end-of-life organ damage throughout the body.
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JNNP: Relationship between sub-tumor-related marginal encephalitis and olive nuclear degeneration under hypertrophobicity
Time of Update: 2021-01-31
identified six patients, all clinically diagnosed as sub-tumor encephalitis, which developed into HOD during the course of the disease.
clinically highly suspected patients with sub-tumor encephalitis, 3t or 7t MRIs may be more sensitive in detecting HOD and DROP lesions, but further research is needed to determine this.
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Nat Commun: How does painful diabetic neuropathy occur?
Time of Update: 2021-01-31
About half of people with diabetic peripheral neuropathy (DPN) experience symptoms of chronic neuropathic pain, including severe tingling/burning and pain, which further leads to anxiety, sleep disorders, and a decline in quality of life.
recently, researchers reported pain-resistant dysfunction mediated by POMC in diabetic sensory neurons.
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Nat Commun: Increased mitochondrial autophagy protects glucoticoid-induced nerve damage
Time of Update: 2021-01-31
failure to remove damaged mitochondrials can induce synaptic steady-state abnormalities in stress-exposed neurons and eventually lead to neurodegenerative diseases.
, the researchers observed that glucosal hormones reduce synaptic density and vesicle recovery due to inhibition of mitochondrial autophagy.
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Heart: Eating more fried foods increases the risk of severe heart disease and stroke
Time of Update: 2021-01-31
January 19, 2021, Hu Foran and others at Shenzhen University's Center for Health Sciences published a research paper entitled: Fried-food products and risk of cardiovascular disease and all-cause mortality: a meta-analysis of observational studies in the journal Heart of BMJ.
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Acta Neuropathologica: Exosome-induced lysosome permeability as a way for exosome tau seeds to escape to cytosomes
Time of Update: 2021-01-31
This paper mainly reveals how tau seeds contained in exosomes use lysosome degradation mechanisms to escape the connotation and induce tau to congreate in cytosytes in "tau biosensor cells" derived from HEK293T.
