Neurology: Bone density is closely related to small vascular disease

Cerebral microvascular disease (SVD) is associated with dementia, stroke and vascular death.
although traditional vascular risk factors such as hypertension and hyperlipidemia are related to the presence and progression of cerebrovascular disease, there is greater uncertainty about their exact pathophysiology, which hinders effective treatment strategies.
White Mass High Signal Lesions (WMH) is one of the most common cerebral SVD esotypes, whose histological characteristics include thickening of arterial walls caused by transparency and fibrosis, large space around blood vessels, deposition of inflammatory cells, and loss of vascular integrity due to damage to the cerebral blood barrier.
, several studies have found a positive correlation between increased arterial stiffness and the burden of brain SVD.
bone density (BMD) is another common critical condition in older people, as it is associated with increased fracture risk and mortality.
recent study showed that osteoporosis is closely related to vascular dysfunction, even stronger than aging factors.
decreased bone density is associated with increased vascular calcification and arteriosclerosis, which can aggravate arterial stiffness and end-of-life organ damage throughout the body.
of older people with no history of stroke have shown that WMH is closely related to osteoporosis.
, however, there is little research focusing on the relationship between BMD and different brain SVD esopses.
addition, the pathophysiological link between bone and brain arteries is unclear.
, Jeong-Min Kim of Seoul National University in South Korea and others studied the link between bone density and SVD in stroke populations.
analyzed data from 1,190 patients with consecutive strokes.
we analyzed data from 1,190 patients over the age of 50 who were tested for both a brain MRI and a dual-energy X-ray absorber.
groups based on the patient's bone density (normal, osteoporosis, and osteoporosis).
the MRI indicators of SVD at the same time: WMH, infarction, micro-travel, vascular clearance to determine SVD score.
, they recruited 70 stroke patients to study serum bone turnover markers and microRNAs associated with both cerebral arteriosclerosis and bone metabolism to understand bone and brain interactions.
results showed that 284 patients (23.9%) were identified as osteoporosis and 450 patients (37.8%) had osteoporosis.
with the decrease of bone density, the total score of SVD and the occurrence of each SVD tytype increased, except for cerebral leaf microemia.
regression analysis showed that osteoporosis was independently associated with a severe SVD burden.
patients with osteoporosis and maximum SVD totals, microRNA-378f levels increased significantly and were positively correlated with thyroid hormones and osteocalcin.
significance of this study is the discovery of a pathophysiological link between bone mineral loss and cerebral arterial degeneration of hypertension, possibly due to circulatory microRNA mediatation.
original origin: Kim, JM, Park, KY, Kim, HR, Ahn, HY, Pantoni, L., Park, MS, ... & Jaehan Bae, D. Association of Bone Mineral Density to Cerebral Small Vessel Disease Burden. _Neurology_ . Freemann Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Originals" are owned by Mets Medicine and are not authorized to be reproduced by any media, website or individual, and are authorized to be reproduced with the words "Source: Mets Medicine".
all reprinted articles on this website are for the purpose of transmitting more information and clearly indicate the source and author, and media or individuals who do not wish to be reproduced may contact us and we will delete them immediately.
at the same time reproduced content does not represent the position of this site.
leave a message here