JNNP: Relationship between bladder fore limb imaging and the efficacy of inner cystic indiesis in patients with obsessive compulsive disorder

The pathophysiology of obsessive compulsive disorder (OCD) involves a cortical-sephedd-mascu brain network in which nerve bundles pass through the fore limbs of the inner sac (aLIC).
Adhesive Imaging (DTI) study of obsessive compulsive disorder has shown different findings, suggesting that patients with obsessive compulsive disorder have whiteness abnormalities in , phospheric and aLIC.
cystic incision and deep brain stimulation targeting aLIC and hypothyroidism (STN) can effectively relieve clinical symptoms in patients with severe obsessive compulsive disorder.
cystic membrane incision is a neurosurgery, including radio frequency, gamma knife or high frequency ultrasound aLIC, after treatment, obsessive compulsive disorder symptoms reduced by an average of a little more than 50%, ranging from 37% to 80%.
to track the effects of abdominal-back position is critical in predicting intracystic results.
of primate nerve beam tracing and human DTI studies show that different regions of aLIC are distributed from fibers in different frontal leaf regions.
this study focuses on specific functional pre-frontal areas associated with obsessive compulsive disorder, including the outer frontal cortical cortical layer (dlPFC), the pre-cortical (OFC), the outer abdominal PFC (vlPFC) (or lower prey cortical cortical), Back-side front buckleback (dACC) and abdominal inner (vmPFC), using fiber beam imaging analysis, focused on the number of whiteness characteristics of aLIC in patients with obsessive compulsive disorder by connecting the symposome, the pasal brain, and the pre-frontal leaf region of the STN cortical subsurface.
recruited obsessive-compulsive disorder patients who under undergoed neurosurgery at Ruijin Hospital from August 2013 to September 2018 .
control group (HCs) with age and gender matching were recruited through community advertising (n-88).
diagnosis of obsessive compulsive disorder is confirmed by a professional doctor.
78 patients with obsessive-compulsive disorder (n-100) who were included in the study underwent instomy of the inner sac.
the stereotactic frame on the patient's head under local anaesthetic and an MRI scan is performed immediately before surgery.
target is between the first and middle third of the aLIC.
the stereotacing target coordinates and target trajectory angles based on stereotacing MRI.
electrodes with a diameter of 2 mm ablation at 75 degrees C for 60 seconds, forming a lesions area with a diameter of 4 to 5 mm and a length of 10 to 12 mm.
assessment was completed at least 6 months after surgery (data included in the analysis related to postoperative improvement), 1 to 5 months after surgery, and 26 cases were unable to contact or participate in follow-up after surgery.
diffusion-weighted imaging was carried out using a 12-channel phased head coil on a Siemens scanner (Siemens, Erlangen, Germany).
obsessive compulsive disorder patients (n-100; average 31.8 years) and HCs patients (n-88; average 29.6 years) at age (t-1.64, p-64) 0.102), gender (female ratio of obsessive compulsive disorder 0.40; HC 0.44; χ2=0.21; p=0.649) varies.
41 patients who underwent cystic instomation and completed the assessment at least 6 months after surgery were included in the analysis associated with postoperative improvement.
in the cerebral cortical connections between dlPFC and dACC, there was a significant correlation between clinical improvement after cystic incision and NC (r=0.34, p<0.0436).
specifically, Y-BOCS improvements (i.e., fewer Y-BOCS than baselines during follow-up) were positively related to NC (r=0.36, p=0.0347) and hyclinic-dACC (r=0.34, p=0.0402) but not to FA.
Compared to the healthy control group, obsessive compulsive disorder was associated with low FA in aLIC in multiple pre-cortical cortical and cortical-sephroid lines (i.e. two-sided dlPFC, vlPFC, back buckle back, ex-SMA, OFC, and vmPFC).
these findings shed light on the important role of aLIC in obsessive compulsive disorder and may help to target precisely to optimize the therapeutic effect of obsessive compulsive disorder.
understanding of the different functional effects of cortological-cortological bundles further highlights the correlation between dimensional symptom invasive and non-invasive neuromodulation therapy targets and other mental illnesses.
Zhang C, Kim S, Li J, et al Anterior limb of the internal capsule tractography: relationship with capsulotomy outcomes in obsessive-compulsive disorderJournal of Neurology, Neurosurgery Psython Published Online First: 18 January 2021. doi:10.1136/jnnp-2020-323062MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that state "Source: Met Medical" or "Source: MedSci Original" are owned by Mace Medical and are not licensed by any media , website or individual may not be reproduced, authorized to be reproduced with the "Source: Metz Medicine".
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