Neurology: Cerebrospinal amyloid is closely related to the sea horse-related memory

Identifying elderly people with AD pathological changes, but cognitively accessible (Cognitive Unimpaired, CU), is key to disease treatment, which is most effective in the asymptomatic (preclinical) stage.
reduction of amyloid protein β (A beta 42) in cerebrospinal fluid and an increase in tau181 (p-tau181) phosphate may be the earliest detection changes in AD pathophysiology.
reduction in CSF amyloid protein-β (A beta 42) and an increase in tau181 (p-tau181) phosphate may be the earliest detectable changes in the AD pathophysiological cascading.
, however, using traditional standardized cognitive testing to detect horizontal associations between CSF and cognition is a challenge.
The test, which is designed to assess the core function of the hippo horse and endoencephalic cortical layer (the early region of the inner temporal lobe MTL affected by tangle) pathology), may be sensitive to subtle changes in memory associated with biomarker abnormalities, in particular the elevation of p-tau181, which is associated with tangle pathology.
"target" stimulation and perception-similar "attractive" stimuli studied by associative memory and memory recognition, the performance of these tasks is closely related to the function of the sea mass.
, the relationship between these markers in the CSF and sea-horse-related memories remains unclear.
by Alexandra N Trelle of Stanford University and others.
cu patients who participated in Stanford's Aging and Memory Study completed a lumbar puncture extraction cerebrospinal fluid and memory assessment.
CSF A beta 42, A beta 40 and p-tau181 (p-tau181) are analyzed and measured in a single batch using the automatic Luluipulse G system. The memory function associated with the sea horse was evaluated with a specific memory assessment scale.
results showed that age was independently associated with an increase in the ratio of A-beta 42/A beta-42 to an increase in p-tau181.
age, A beta 42/A beta 40, and p-tau181 were associated with a) poor associated memory and b) decreased memory discernment under different degrees of tasks.
, P-tau mediates the effects of A-beta 42/A beta-40 on memory.
relationship between CSF protein and delayed memory is similar, but not significant.
A beta 42 was not significantly associated with p-tau181 or memory.
significance of this study is the discovery that in CU patients, specific memory tests based on the function of the hema can distinguish between memory differences between individuals.
and these sea horse-related memory capabilities were associated with changes in biomarkers associated with early AD in CSF.
these tests may help identify older people with AD pathology but no cognitive impairment.
origins: Trelle, A. N., Carr, V. A., Wilson, E.N., Swarovski, M.S., Hunt, M.P., Toueg, T.N., Tran, T.T., Channappa, D., Corso, N. K., Thieu, M.K., Jayakumar, M., Nadiadwala, A., Guo, W., Tanner, N.J., Bernstein, J.D., Litovsky, C.P., Guerin, S.A., Khazenzon, A.M. Harrison, M.B. Mormino, E.C. (2021). Association of CSF Biomarkers with Hippocampal-dependent Memory in Preclinical Alzheimer Disease. Neurology, 10.1212/WNL.0000000000011477. Advance online publication. Freeman Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Originals" are owned by Mets Medical and are not reproduced by any media, website or individual without authorization, and are authorized to be reproduced with the words "Source: Mets Medicine".
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